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    COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE
    2.
    发明申请
    COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE 审中-公开
    多种PROSTAGLANDIN受体的化合物作用产生一般的抗炎反应

    公开(公告)号：US20140121258A1

    公开(公告)日：2014-05-01

    申请号：US13808020

    申请日：2011-07-01

    申请人： David F. Woodward ,  William R. Carling ,  Jose L. Martos ,  Jenny W. Wang ,  Jussi J. Kangasmetsa

    发明人： David F. Woodward ,  William R. Carling ,  Jose L. Martos ,  Jenny W. Wang ,  Jussi J. Kangasmetsa

    IPC分类号： C07D231/12

    CPC分类号： C07D231/12 ,  A61K31/415

    摘要： The present invention provides a compound, that is a 1-[(2-{[(alkyl or aryl)methyl]oxyl}halo or haloalkyl substituted-phenyl)alkyl]-5-hydrocarbyl or substituted hydrocarbyl-1H-pyrazole carboxylic acid or alkylenylcarboxylic acid or a hydrocarbyl or substituted hydrocarbyl sulfonamide of said carboxylic acid or said alkylenylcarboxylic acid, provided however said compound is not a 3-carboxylic acid, a sulfonamide thereof, or a 3-methylenylcarboxylic acid. The compound may be represented by the following formula (I). Wherein R1, R2, R3, R4, R5, R6, X, W, X and Y are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, TP and/or EP4 receptor mediated diseases or conditions.

    摘要翻译： 本发明提供一种化合物，即1 - [（2 - {[（烷基或芳基）甲基]氧基}卤代或卤代烷基取代的苯基）烷基] -5-烃基或取代的烃基-1H-吡唑羧酸或 亚烷基羧酸或所述羧酸或所述烷基烯基羧酸的烃基或取代的烃基磺酰胺，但是所述化合物不是3-羧酸，其磺酰胺或3-甲基烯基羧酸。 化合物可以由下式（I）表示。 其中R1，R2，R3，R4，R5，R6，X，W，X和Y如说明书中所定义。 可以施用化合物以治疗DP1，FP，EP1，TP和/或EP4受体介导的疾病或病症。

    Method of enhancing hair growth
    3.
    发明授权
    Method of enhancing hair growth 有权
    增加头发生长的方法

    公开(公告)号：US08632760B2

    公开(公告)日：2014-01-21

    申请号：US13441783

    申请日：2012-04-06

    申请人： David F. Woodward ,  Amanda M. VanDenburgh

    发明人： David F. Woodward ,  Amanda M. VanDenburgh

    IPC分类号： A61K8/00

    CPC分类号： A61K8/42 ,  A61K8/042 ,  A61K8/06 ,  A61K31/165 ,  A61K31/557 ,  A61K31/558 ,  A61K2800/10 ,  A61Q7/00 ,  A61Q7/02

    摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.

    摘要翻译： 公开了用于刺激毛发生长的方法和组合物，其中所述组合物包括环戊烷庚酸，由式I表示的2-环烷基或芳基烷基化合物，其中虚线键代表单键或双键，其可以是顺式或反式构型 A，B，Z，X，R 1和R 2如说明书中所定义。 这样的组合物用于治疗人或非人动物的皮肤或头皮。 比马前列素优选用于治疗。

    METHOD OF ENHANCING HAIR GROWTH
    6.
    发明申请
    METHOD OF ENHANCING HAIR GROWTH 有权
    增加头发生长的方法

    公开(公告)号：US20120122989A1

    公开(公告)日：2012-05-17

    申请号：US13356284

    申请日：2012-01-23

    申请人： David F. Woodward ,  Amanda M. Vandenburgh

    发明人： David F. Woodward ,  Amanda M. Vandenburgh

    IPC分类号： A61K31/165 ,  A61P17/14

    CPC分类号： A61K8/42 ,  A61K8/042 ,  A61K8/06 ,  A61K31/165 ,  A61K31/557 ,  A61K31/558 ,  A61K2800/10 ,  A61Q7/00 ,  A61Q7/02

    摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.

    摘要翻译： 公开了用于刺激毛发生长的方法和组合物，其中所述组合物包括环戊烷庚酸，由式I表示的2-环烷基或芳基烷基化合物，其中虚线键代表单键或双键，其可以是顺式或反式构型 A，B，Z，X，R 1和R 2如说明书中所定义。 这样的组合物用于治疗人或非人动物的皮肤或头皮。 比马前列素优选用于治疗。

    Method of enhancing hair growth
    9.
    发明授权
    Method of enhancing hair growth 有权
    增加头发生长的方法

    公开(公告)号：US07351404B2

    公开(公告)日：2008-04-01

    申请号：US10345788

    申请日：2003-01-15

    申请人： David F. Woodward ,  Amanda M. VanDenburgh

    发明人： David F. Woodward ,  Amanda M. VanDenburgh

    IPC分类号： A61K8/00

    CPC分类号： A61K8/42 ,  A61K8/042 ,  A61K8/06 ,  A61K31/165 ,  A61K31/557 ,  A61K31/558 ,  A61K2800/10 ,  A61Q7/00 ,  A61Q7/02

    摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.

    摘要翻译： 公开了用于刺激毛发生长的方法和组合物，其中所述组合物包括环戊烷庚酸，由式I表示的2-环烷基或芳基烷基化合物，其中虚线键代表单键或双键，其可以是顺式或反式构型 A，B，Z，X，R 1和R 2均如说明书中所定义。 这样的组合物用于治疗人或非人动物的皮肤或头皮。 比马前列素优选用于治疗。

    Thromboxane ligands without blood clotting side effects
    10.
    发明授权
    Thromboxane ligands without blood clotting side effects 失效

    公开(公告)号：US07019149B2

    公开(公告)日：2006-03-28

    申请号：US10943549

    申请日：2004-09-17

    申请人： Robert M. Burk ,  Achim H-P Krauss ,  David F. Woodward

    发明人： Robert M. Burk ,  Achim H-P Krauss ,  David F. Woodward

    IPC分类号： C07D307/00 ,  C07D311/00 ,  C07D321/02

    CPC分类号： C07D307/00 ,  A61K31/558 ,  C07D319/08 ,  C07D493/08

    摘要： A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, wherein Y is (CH2)x; Z is selected from the group consisting of and (CR2)x, x is an integer of 1 or 2; n is 0 or 1; R2 is hydrogen or an alkyl radical of from 1 to 4 carbons; A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxa or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein the heteroatom is selected from the group consisting of nitrogen, oxygen and sulfur atoms, or substituted derivatives of said methyl, cycloalkyl or aryl radicals wherein said substituent is selected from the group consisting of halo, nitro, amino, thiol, hydroxy, alkyloxy and alkylcarboxy; and X is selected from the group consisting of nitro, cyano, —COOR, —CH2OR1, —C(O)N(R1)2, —CH2N(R1)2—CH═N—OH and —CH2SR1 radicals wherein R is a C1 to C10 alkyl, phenyl or benzyl and R1 is R or hydrogen; or a pharmaceutically acceptable salt thereof.