摘要:
The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrant Stat3 pathway activity; to pharmaceutical compositions containing such compounds.
摘要:
A method is provided for evaluating the tension or laxity of the soft tissue surrounding a patient's knee joint. Based on this evaluation, a surgeon may determine a desired resection depth for a knee arthroplasty procedure that will achieve an appropriate spacing between adjacent, articulating components of the knee joint.
摘要:
The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.
摘要:
A patient-specific porous metal prosthesis and a method for manufacturing the same are provided. The orthopaedic prosthesis may be metallic to provide adequate strength and stability. Also, the orthopaedic prosthesis may be porous to promote bone ingrowth.
摘要:
An image of a scanned book is segmented using a feature image to map pixels corresponding to a page area and to create page objects and detect borders of the page. A book spine region is detected by locating a plain background area between two of the page objects, analyzing the page borders to detect their shape, and analyzing their shape to detect the book spine end points. Using the page borders, the feature image is examined to detect top-to-bottom and bottom-to-top declines in pixel values to determine the corners of a shadow distortion in the original scanned image. Squeeze and curvature distortion are also detected. A Bezier curve is used to model each of the three distortions detected on the page. The detected distortion is corrected by first defining a trapezoidal correction area. The intensity, squeeze, and curvature corrections are then applied along lines within the trapezoidal correction area.
摘要:
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
摘要:
A computerized annotation method achieves real-time operation and better optimization properties while preserving the architectural advantages of the generative modeling approach. A novel clustering algorithm for objects is represented by discrete distributions, or bags of weighted vectors, thereby minimizing the total within cluster distance, a criterion used by the k-means algorithm. A new mixture modeling method, the hypothetical local mapping (HLM) method, is used to efficiently build a probability measure on the space of discrete distributions. Thus, in accord with the invention every image is characterized by a statistical distribution. The profiling model specifies a probability law for distributions directly.
摘要:
In a system and method for the generation of attack-resistant, user-friendly, image-based CAPTCHAs (Completely Automated Public test to Tell Computers and Humans Apart), controlled distortions are applied to randomly chosen images and presented to a user for annotation from a given list of words. An image is presented that contains multiple connected but independent images with the borders between them distorted or otherwise visually obfuscated in a way that a computer cannot distinguish the borders and a user selects near the center of one of the images. The distortions are performed in a way that satisfies the incongruous requirements of low perceptual degradation and high resistance to attack by content-based image retrieval systems. Word choices are carefully generated to avoid ambiguity as well as to avoid attacks based on the choices themselves.
摘要:
A method for automatically designing a buffer packing size and a computer accessible storage media to store program thereof are provided. First, a buffer thickness of a buffer material is calculated, and a buffer area for a surface of the object receiving an impact is calculated according to a weight of an object and a static stress of the buffer material. Next, a suitable buffer packing size is automatically calculated according to the buffer thickness and the buffer area.
摘要:
A process for forming isolation and active regions, wherein the patterning of an oxidation-barrier active stack is performed separately in the PMOS and NMOS regions. After the active stack is in place, two masking steps are used: one exposes the isolation areas on the NMOS side, for stack etch, channel-stop implant, and silicon recess etch (optional); the other masking step is exactly complementary, and performs the analogous operations on the PMOS side. After these two steps are performed (in either order), an additional nitride layer can optionally be deposited and etched to cover the sidewall of the active stack. Field oxide is then formed, and processing then proceeds in conventional fashion.