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42 条记录 (耗时 0.018 秒)

    Benzothiazolyl oxanic acids, esters and salts
    11.
    发明授权
    Benzothiazolyl oxanic acids, esters and salts 失效
    苯并噻唑基恶烷酸，酯和盐

    公开(公告)号：US4150140A

    公开(公告)日：1979-04-17

    申请号：US753717

    申请日：1976-12-23

    申请人： Charles M. Hall ,  John B. Wright

    发明人： Charles M. Hall ,  John B. Wright

    IPC分类号： C07D277/82 ,  A61K31/425

    CPC分类号： C07D277/82

    摘要： Compounds of the formula ##STR1## wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, nitro, cyano, amino, trifluoromethyl, ##STR2## wherein R.sub.1 is alkyl of one to six carbon atoms, inclusive, ##STR3## wherein R.sub.2 and R.sub.3 are the same or different and are hydrogen or alkyl of one to three carbon atoms inclusive, or CO.sub.2 Q where Q is alkyl of one to six carbon atoms, inclusive, hydrogen or a physiologically acceptable metal or amine cation; andR is hydrogen, alkyl of one to eight carbon atoms, inclusive, --CH.sub.2).sub.m phenyl wherein m is 0, 1 or 2 or (CH.sub.2).sub.n NR.sub.4 R.sub.5 wherein n is 1 or 2, and R.sub.4 and R.sub.5 are the same or different and are alkyl of one to three carbon atoms, inclusive, and a physiologically acceptable metal or amine cation; and physiologically acceptable acid addition salts thereof are formulated into pharmaceutical compositions suitable for oral, parenteral or inhalation administration which are used as prophylactic inhibitors of allergic manifestations in sensitized mammals.

    摘要翻译： 其中X和Y相同或不同并且是氢，氟，氯，溴，1-6个碳原子的烷基，包括1至6个碳原子的烷氧基，包括硝基，氰基， 氨基，三氟甲基，其中R 1是1至6个碳原子的烷基，包括端值，其中R 2和R 3相同或不同，是氢或一至三个碳原子的烷基，或其中Q是 1-6个碳原子的烷基（包括端值），氢或生理上可接受的金属或胺阳离子; 且R为氢，一至八个碳原子的烷基，包括端基的-CH 2）m苯基，其中m为0,1或2或（CH 2）n NR 4 R 5，其中n为1或2，并且R 4和R 5相同或不同， 是一至三个碳原子的烷基，包括端基和生理上可接受的金属或胺阳离子; 并将其生理上可接受的酸加成盐配制成适用于口服，肠胃外或吸入给药的药物组合物，其用作敏化哺乳动物过敏表现的预防性抑制剂。

    Anti-allergic oxanil compounds
    12.
    发明授权
    Anti-allergic oxanil compounds 失效
    抗过敏牛il嗪化合物

    公开(公告)号：US4128570A

    公开(公告)日：1978-12-05

    申请号：US839863

    申请日：1977-10-06

    申请人： Charles M. Hall ,  John B. Wright

    发明人： Charles M. Hall ,  John B. Wright

    IPC分类号： A61K31/24 ,  A61K31/275 ,  C07C255/58 ,  C07C121/78

    CPC分类号： A61K31/275 ,  A61K31/24 ,  C07C255/58

    摘要： A method of treating mammals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature which comprises administering prophylactically to said mammal an anti-allergy or anaphylactic reaction effective amount of a compound of the formula ##STR1## Novel compounds and compositions are also claimed.

    摘要翻译： 一种治疗哺乳动物用于过敏反应和过敏反应的方法，其包括对所述哺乳动物预防性施用抗过敏或过敏反应有效量的下式化合物新颖的化合物和组合物也是 声称。

    Compositions and process of treatment
    15.
    发明授权
    Compositions and process of treatment 失效
    组合物和治疗过程

    公开(公告)号：US3987192A

    公开(公告)日：1976-10-19

    申请号：US489620

    申请日：1974-07-18

    申请人： John B. Wright

    发明人： John B. Wright

    IPC分类号： A61K31/275

    CPC分类号： A61K31/275

    摘要： This invention relates to pharmaceutical compositions containing known compounds of the formula ##SPC1##Wherein M is selected from the group consisting of hydrogen, aluminum, ammonium, sodium, potassium, calcium, tris(hydroxymethyl)methylammonium and lower alkyl of 1 through 4 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms, and R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkoxy of 1 through 4 carbon atoms and lower alkyl of 1 through 4 carbon atoms.The compounds (1) above are formulated with pharmaceutical carriers for inhalation or for oral, parenteral or rectal administration, with insufflation being the preferred method. The compositions are useful in the prophylactic treatment of sensitized humans and mammals for allergic and all anaphylactic reactions of a reaginmediated and non-reagin-mediated nature.

    Derivatives of 4,6 dioxopyrido[3,2-g]quinoline 2,8 dicarboxylic acid
    16.
    发明授权
    Derivatives of 4,6 dioxopyrido[3,2-g]quinoline 2,8 dicarboxylic acid 失效
    衍生物为4,6二氧吡啶并[8，3,2-g {9喹啉2,8二羧酸

    公开(公告)号：US3959289A

    公开(公告)日：1976-05-25

    申请号：US531759

    申请日：1974-12-11

    申请人： Charles M. Hall ,  Herbert G. Johnson ,  John B. Wright

    发明人： Charles M. Hall ,  Herbert G. Johnson ,  John B. Wright

    IPC分类号： C07C205/12 ,  C07C205/37 ,  C07D471/04

    CPC分类号： C07C205/12 ,  C07C205/37

    摘要： Novel chemical compounds of the formula: ##SPC1##WhereinR is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, phenyl, alkali metal, or an amine cation;X and Y can be the same or different and are selected from the group consisting of hydrogen, alkyl of from one to six carbon atoms, inclusive, cycloalkyl of 5 or 6 carbon atoms, inclusive, phenyl, hydroxyl, alkoxy having from one to three carbon atoms, inclusive, halogen, trifluoromethyl, cyano, carboxyamide and O C-OQ, ##EQU1## where Q is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, alkali metal, and an amine cation, with the proviso that whereR is hydrogen, alkali metal or an amine cation, then Q is the same as R, and whereR is phenyl or alkyl from one to three carbon atoms, then Q is phenyl or alkyl from one to three carbon atoms; andZ is selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, and phenyl.The compounds are formulated with pharmaceutical carriers for oral or parenteral administration, with insufflation being the preferred method. The compositions are useful in the prophylactic treatment of sensitized humans and mammals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.

    摘要翻译： 新型化学式：

    Benzothiazole derivatives
    20.
    发明授权
    Benzothiazole derivatives 失效
    苯并噻唑衍生物

    公开(公告)号：US4423223A

    公开(公告)日：1983-12-27

    申请号：US155712

    申请日：1980-06-02

    申请人： Charles M. Hall ,  John B. Wright

    发明人： Charles M. Hall ,  John B. Wright

    IPC分类号： C07D277/82 ,  C07D277/62

    CPC分类号： C07D277/82

    摘要： Novel compounds of the formula ##STR1## wherein X and Y are the same or different and are hydrogen, fluora, chloro, bromo, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, nitro, cyano, amino, trifluoromethyl, ##STR2## wherein R.sub.1 is alkyl of one to six carbon atoms, inclusive, ##STR3## wherein R.sub.2 and R.sub.3 are the same or different and are hydrogen or alkyl of one to three carbon atoms inclusive, or CO.sub.2 Q where Q is alkyl of one to six carbon atoms, inclusive, hydrogen or a physiologically acceptable metal or amine cation; and R is hydrogen, alkyl of one to eight carbon atoms, inclusive, --CH.sub.2).sub.m phenyl wherein m is 0, 1 or 2 or (CH.sub.2).sub.n NR.sub.4 R.sub.5 wherein n is 1 or 2, and R.sub.4 and R.sub.5 are the same or different and are alkyl of one to three carbon atoms, inclusive, and a physiologically acceptable metal or amine cation; and physiologically acceptable acid addition salts thereof are formulated into pharmaceutical compositions suitable for oral, parenteral or inhalation administration which are used as prophylactic inhibitors of allergic manifestations in sensitized mammals.

    摘要翻译： 新颖的式（Ⅰ）化合物，其中X和Y相同或不同，为氢，氟，氯，溴，含1-6个碳原子的烷基，包括1至6个碳原子的烷氧基，包括硝基，氰基 ，其中R 1为1至6个碳原子的烷基，其中R 2和R 3相同或不同，为氢或含1至3个碳原子的烷基或CO 2 Q，其中Q 是1-6个碳原子的烷基（包括端值），氢或生理上可接受的金属或胺阳离子; 且R为氢，一至八个碳原子的烷基，包括端基的-CH 2）m苯基，其中m为0,1或2或（CH 2）n NR 4 R 5，其中n为1或2，并且R 4和R 5相同或不同， 是一至三个碳原子的烷基，包括端基和生理上可接受的金属或胺阳离子; 并将其生理上可接受的酸加成盐配制成适用于口服，肠胃外或吸入给药的药物组合物，其用作敏化哺乳动物过敏表现的预防性抑制剂。