公开(公告)号：US07317948B1

公开(公告)日：2008-01-08

申请号：US10364436

申请日：2003-02-11

Applicant: John D H King ,  James R Thacker

Inventor： John D H King ,  James R Thacker

IPC: A61N1/00

CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

Abstract translation: 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US07146223B1

公开(公告)日：2006-12-05

申请号：US10355955

申请日：2003-01-31

Applicant: John D. H. King

Inventor： John D. H. King

IPC: A61N1/04

CPC classification number: A61N1/36071 ,  Y10S128/92

Abstract: A method for selecting Spinal Cord Stimulation (SCS) stimulation parameter sets guides a clinician towards an effective set of stimulation parameters. The clinician first evaluates the effectiveness of a small number of trial stimulation parameter sets from a Measurement Table. Based on the patient's assessment, the trial stimulation sets are ranked. Then the clinician selects a starting or benchmark row in a Steering Table corresponding to the highest ranked trial stimulation parameter set. The clinician moves either up or down from the starting row, testing consecutive parameter sets. When a local optimum is found, the clinician returns to the benchmark row, and tests in the opposite direction for another local optimum. This process of searching for optimum parameter sets is repeated for a new starting row in the Steering Table that is selected based on the next ranked trial set from the Measurement Table.

Abstract translation: 用于选择脊髓刺激（SCS）刺激参数组的方法引导临床医生朝向有效的一组刺激参数。 临床医生首先从测量表中评估少量试验刺激参数组的有效性。 根据患者的评估，试验刺激集合排名。 然后，临床医生在对应于最高排名的试验刺激参数集的转向表中选择起始或基准行。 临床医生从起始行向上或向下移动，测试连续的参数集。 当找到局部最佳值时，临床医生返回到基准行，并以相反方向测试另一个局部最佳值。 对于基于从测量表中的下一个排名的试验集选择的转向表中的新起始行，重复搜索最佳参数集的该过程。

公开(公告)号：US08443615B2

公开(公告)日：2013-05-21

申请号：US12950931

申请日：2010-11-19

Applicant: John D. H. King ,  Nicholas A. Kramer ,  Thomas E. Oliver

Inventor： John D. H. King ,  Nicholas A. Kramer ,  Thomas E. Oliver

IPC: F25B1/00

CPC classification number: F24S23/77 ,  F24S10/72 ,  F24S10/73 ,  F24S20/25 ,  F24S20/70 ,  F24S20/80 ,  F24S23/81 ,  F24S23/82 ,  F24S30/425 ,  Y02E10/44 ,  Y02E10/47

Abstract: A dry cooling assembly is provided comprising a supporting body of liquid having a temperature higher than ambient temperature, and an inflatable elongated tube at least partially submerged in the supporting body of liquid. The inflatable elongated tube has an upper portion formed at least partially of flexible material and a lower ballast portion formed at least partially of flexible material. The lower ballast portion defines a reservoir containing liquid facilitating ballast. The liquid facilitating ballast is warmed by heat from the supporting body of liquid such that the temperature of the support body of liquid is reduced.

Abstract translation: 提供了一种干燥冷却组件，其包括具有高于环境温度的温度的液体的支撑体，以及至少部分地浸没在液体支撑体中的可充气细长管。 可充气细长管具有至少部分由柔性材料形成的上部部分和至少部分由柔性材料形成的下部压载部分。 下部压载部分限定了容纳用于镇流器的液体的储存器。 液体促进镇流器通过来自液体支撑体的热量加热，使得液体的支撑体的温度降低。

公开(公告)号：US08434626B2

公开(公告)日：2013-05-07

申请号：US12705902

申请日：2010-02-15

Applicant: John D. H. King ,  Keeney D. Willis

Inventor： John D. H. King ,  Keeney D. Willis

IPC: B03B5/00

CPC classification number: C12N1/02 ,  C12M21/02 ,  C12M23/06 ,  C12M23/18 ,  C12M27/20 ,  C12M29/02 ,  C12M33/10 ,  C12N1/12 ,  Y02W10/37

Abstract: A system and related method for concentrating biological culture and circulating biological culture and process fluid is provided. The system includes a continuous flow separator that removes excess fluid from the culture medium, resulting in a “concentrated medium” of fluid. The concentrated medium is then passed along for further processing to capture the biomass. The overflow, i.e., the extracted fluid, from the continuous flow separator is reintroduced into the container in a manner to circulate the culture medium. Thus, energy from the concentration step is utilized to circulate the culture medium, alleviating the need for significant additional structure for circulating the culture medium. In this manner, the system grows and captures biological material in an energy and capital efficient manner.

Abstract translation: 提供了一种用于浓缩生物培养和循环生物培养和过程流体的系统和相关方法。 该系统包括连续流分离器，其从培养基中除去多余的流体，导致流体的“浓缩介质”。 然后将浓缩的介质通过以进行进一步处理以捕获生物质。 来自连续流分离器的溢出物，即提取的流体以使循环培养基的方式被重新引入到容器中。 因此，利用来自浓缩步骤的能量来循环培养基，减轻了对用于循环培养基的显着额外结构的需要。 以这种方式，系统以能量和资本有效的方式增长和捕获生物材料。

公开(公告)号：US07657317B2

公开(公告)日：2010-02-02

申请号：US11115789

申请日：2005-04-26

Applicant: James R. Thacker ,  Carla M. Woods ,  Sridhar Kothandaraman ,  John D. H. King ,  Kerry Bradley

Inventor： James R. Thacker ,  Carla M. Woods ,  Sridhar Kothandaraman ,  John D. H. King ,  Kerry Bradley

IPC: A61N1/36

CPC classification number: G06F19/3481 ,  A61N1/36071 ,  G06F19/00 ,  G16H40/63

Abstract: A tissue stimulation system is provided that evaluates and/or scores stimulation sets based on both patient feedback and frequency of use. Stimulation sets and any associated scores and/or usage may be stored in a retrievable database. Upon subsequent stimulation sessions, a patient may select stimulation sets that have a high score and/or usage in order to effectively meet therapeutic objectives. Methods of determining patient satisfaction, which involve evaluating patient pain before and after stimulation pulses are applied, are also provided herein.

Abstract translation: 提供组织刺激系统，其基于患者反馈和使用频率来评估和/或评估刺激组。 刺激集和任何相关的分数和/或使用可以存储在可检索的数据库中。 在随后的刺激会话中，患者可以选择具有高得分和/或使用的刺激组，以便有效地满足治疗目标。 本文还提供了确定患者满意度的方法，其涉及在刺激脉冲之前和之后评估患者疼痛。