公开(公告)号：US5236695A

公开(公告)日：1993-08-17

申请号：US757880

申请日：1991-09-11

Applicant: Harry S. Winchell ,  Joseph Y. Klein ,  Elliot D. Simhon ,  Rosa L. Cyjon ,  Ofer Klein ,  Haim Zaklad

Inventor： Harry S. Winchell ,  Joseph Y. Klein ,  Elliot D. Simhon ,  Rosa L. Cyjon ,  Ofer Klein ,  Haim Zaklad

IPC: A61K49/06 ,  C07F9/6524 ,  G01R33/28

CPC classification number: G01R33/5601 ,  A61K49/06 ,  C07F9/6524 ,  Y10S436/806 ,  Y10S514/836 ,  Y10T436/24

Abstract: Polyphosphonate ligands containing three or more phosphonate groups, combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI contrast enhancement agents, which tend to localize in bone tissue without being conjugated to bone-specific biomolecules. Triazacyclononanes and tetraazacyclododecanes, with dihydroxyphosphorylmethyl or dihydroxyphosphorylethyl groups, optionally substituted at the methyl or ethyl bridges with alkyl, aryl, hydroxyl or amino groups, are particularly preferred.

Abstract translation: 含有三个或更多个膦酸酯基团的多膦酸酯配体与顺磁性金属阳离子组合并以药理学上可接受的盐的形式施用可用作MRI对比度增强剂，其倾向于定位在骨组织中而不与骨特异性生物分子缀合。 三氮杂环壬烷和四氮杂环十二烷与任选在甲基或乙基桥上被烷基，芳基，羟基或氨基取代的二羟基磷酰基甲基或二羟基磷酰基乙基是特别优选的。

公开(公告)号：US4996948A

公开(公告)日：1991-03-05

申请号：US431082

申请日：1989-11-03

Applicant: Valerie L. Klein ,  Paul P. Klein

Inventor： Valerie L. Klein ,  Paul P. Klein

IPC: A01K27/00

CPC classification number: A01K27/001

Abstract: An animal slip collar made of flexible material such as chain links has a ring at one end through which the material is passed to form a loop. An intermediate section of the collar is made of material heavier than the end sections but dimensioned to pass through the ring. When the loop is passed around the animal's neck the extra weight of the intermediate material causes the loop to adjust itself so that the intermediate section is at its low point and the ring is opposite on the back of the animal's neck.

Abstract translation: 由柔性材料（如链节）制成的动物滑环在一端具有一个环，材料通过该环通过以形成环。 套环的中间部分由比端部重的材料制成，但是尺寸设计成穿过环。 当环路绕过动物的颈部时，中间材料的额外重量使得环路自身调节，使得中间部分处于其低点，并且环在动物颈部的背面相对。

公开(公告)号：US4472059A

公开(公告)日：1984-09-18

申请号：US425929

申请日：1982-09-28

Applicant: Reuben Klein ,  Imrich Klein

Inventor： Reuben Klein ,  Imrich Klein

IPC: B29C48/395 ,  B01F7/08

CPC classification number: B29C47/38 ,  B29C47/6006 ,  B29C47/0009

Abstract: A plasticating extruder screw conveyor includes multiple primary flights and corresponding multiple secondary flights defining multiple channels on the screw conveyor arranged about the longitudinal axis of the screw conveyor such that radial components of forces between the screw conveyor and unplasticated material located in the channels are substantially balanced so as to reduce to a minimum any resultant radial force upon the screw conveyor and any concomitant lateral deflection of the screw conveyor, thereby reducing or eliminating excessive vibration, wear or galling of the screw conveyor.

Abstract translation: 塑化挤出机螺旋输送机包括在螺旋输送机上围绕螺旋输送机的纵向轴线限定多个通道的多个主要飞行和相应的多个二次叶轮，使得螺旋输送机和位于通道中的未增塑材料之间的力的径向分量基本平衡 从而将螺旋输送机上的任何合成的径向力减小到螺旋输送机的任何伴随的横向偏转，从而减少或消除螺旋输送机的过度振动，磨损或磨损。

公开(公告)号：US4171195A

公开(公告)日：1979-10-16

申请号：US852228

申请日：1977-11-17

Applicant: Reuben Klein ,  Imrich Klein ,  Yigal Cidon

Inventor： Reuben Klein ,  Imrich Klein ,  Yigal Cidon

IPC: B29C48/325 ,  B29C48/34 ,  B29C48/92 ,  B29D23/04

CPC classification number: B29C47/92 ,  B29C47/0816 ,  B29C47/22 ,  B29C47/24 ,  B29C47/28 ,  B29C2947/92152 ,  B29C2947/92428 ,  B29C2947/926 ,  B29C2947/92647 ,  B29C2947/92904 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/20

Abstract: A cross-head die in which the manifold is provided with means for selectively varying the volume of the manifold at some locations relative to other locations, whereby the relative wall thickness about the annular configuration of the material flowing through the die is selectively adjusted about the periphery of the annular configuration of flowing material. Wall thickness and configuration are further controlled at the outlet orifice of the die by means movable to selectively expand, contract and alter the annular configuration of the die passage at the orifice.

Abstract translation: 十字头模具，其中歧管设置有用于在相对于其他位置的某些位置选择性地改变歧管的体积的装置，由此围绕流过模具的材料的环形构型的相对壁厚围绕 流动材料的环形结构的周边。 通过可移动的选择性地膨胀，收缩和改变孔口处的模具通道的环形构造，壁厚度和结构进一步控制在模具的出口孔处。

公开(公告)号：US4095904A

公开(公告)日：1978-06-20

申请号：US687845

申请日：1976-05-19

Applicant: Hans Joachim Klein ,  Fritz Henze ,  Bernhard Vinzelberg, deceased ,  by Susanne Klein nee Vinzelberg, heir

Inventor： Hans Joachim Klein ,  Fritz Henze ,  Bernhard Vinzelberg, deceased ,  by Susanne Klein nee Vinzelberg, heir

IPC: G01J1/04 ,  G01N21/90 ,  G01N33/00 ,  G01N21/24

CPC classification number: G01N21/9027 ,  G01N2033/0081

Abstract: The device is based on an optical transmission arrangement in which a signal change occurs when a foreign body is present in the liquid. By means of a rotating device the cylindrical container to be tested is set in rotation and subsequently braked. Then optical testing is carried out. The light beams passing through the container are picked up by a plurality of photo electric detectors arranged above one another. The photodetectors are divided into groups, which are each switched on sequentially be a programme control unit from top to bottom to effect the measurement, with one photodector group being switched on when the vortex of liquid occurring as a result of the container rotation has subsided after the standstill of the container and disappeared from the field of view of the photodector group.

Abstract translation: 该装置基于当异物存在于液体中时发生信号变化的光传输装置。 通过旋转装置，待测试的圆柱形容器旋转并随后制动。 然后进行光学测试。 通过容器的光束被彼此上下布置的多个光电检测器拾取。 光电检测器被分成组，每个组分别从上到下依次切换为程序控制单元以进行测量，当由于容器旋转而发生的液体涡流已经消退时，一个光电探测器组被接通 容器的停顿并从光电探测器组的视野消失。

公开(公告)号：US2795232A

公开(公告)日：1957-06-11

申请号：US52043855

申请日：1955-07-07

Applicant: KLEIN GOLDIE J ,  BENJAMIN KLEIN

Inventor： KLEIN GOLDIE J ,  BENJAMIN KLEIN

IPC: A45D8/34

CPC classification number: A45D8/34

公开(公告)号：US2742723A

公开(公告)日：1956-04-24

申请号：US19442850

申请日：1950-11-07

Applicant: GOLDIE KLEIN ,  BENJAMIN KLEIN

Inventor： GOLDIE KLEIN ,  BENJAMIN KLEIN

IPC: B42D15/04

CPC classification number: B42D15/042 ,  B42D15/04

公开(公告)号：US2503747A

公开(公告)日：1950-04-11

申请号：US54043444

申请日：1944-06-15

Applicant: JACOBS KLEIN GOLDIE ,  BENJAMIN KLEIN

Inventor： JACOBS KLEIN GOLDIE ,  BENJAMIN KLEIN

IPC: B42D15/02

CPC classification number: B42D15/02 ,  Y10S493/959

公开(公告)号：US2070663A

公开(公告)日：1937-02-16

申请号：US7945236

申请日：1936-05-13

Applicant: KLEIN CALVIN W ,  LEO ESTEROW ,  ABRAHAM KLEIN

Inventor： KLEIN CALVIN W ,  LEO ESTEROW ,  ABRAHAM KLEIN

IPC: A47J36/12

CPC classification number: A47J36/12

公开(公告)号：US20170100331A1

公开(公告)日：2017-04-13

申请号：US15291417

申请日：2016-10-12

Applicant: JEFFREY ALAN KLEIN ,  PAYTRA ALAN KLEIN

Inventor： JEFFREY ALAN KLEIN ,  PAYTRA ALAN KLEIN

IPC: A61K9/00 ,  A61K31/546 ,  A61K31/52 ,  A61K31/137 ,  A61K47/02 ,  A61K31/167 ,  A61K31/522

CPC classification number: A61K9/0019 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4164 ,  A61K31/52 ,  A61K31/522 ,  A61K31/546 ,  A61K45/06 ,  A61K47/02 ,  A61K2300/00

Abstract: Disclosed are methods of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject a tumescent composition comprising: (a) the drug or the therapeutic agent, wherein a tumescent concentration of the drug is simultaneously: 1) below a threshold for local, subcutaneous tissue toxicity, 2) above a threshold for positive local therapeutic effect, and 3) above a concentration achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; (b) a vasoconstrictor; and (c) a pharmaceutically acceptable carrier. Some embodiments relate to a method of treating or preventing sepsis or Systemic Inflammatory Response Syndrome (SIRS) in a subject. Some embodiments relate to a tumescent solution for treating a localized viral infection, e.g., varicella-zoster (shingles), the tumescent solution comprising an antiviral agent.