公开(公告)号：US08410146B2

公开(公告)日：2013-04-02

申请号：US12457479

申请日：2009-06-11

Applicant: Ju Young Lee ,  Jae-Sun Kim ,  Jung-Hoon Oh ,  Hoe-chul Jung ,  Hyun Jung Lee ,  Sang-hwan Kang ,  Yong-Hyuk Kim ,  Sung-hoon Park ,  Keun-Ho Ryu ,  Jung Bum Yi ,  Hun-Taek Kim ,  Key-An Um ,  Bong-yong Lee

Inventor： Ju Young Lee ,  Jae-Sun Kim ,  Jung-Hoon Oh ,  Hoe-chul Jung ,  Hyun Jung Lee ,  Sang-hwan Kang ,  Yong-Hyuk Kim ,  Sung-hoon Park ,  Keun-Ho Ryu ,  Jung Bum Yi ,  Hun-Taek Kim ,  Key-An Um ,  Bong-yong Lee

IPC: A61K31/44

CPC classification number: C04B35/632 ,  C07D401/14

Abstract: 2-pyridyl substituted imidazoles of the formula (I) as shown in claim 1, are provided, which are useful in the treatment of diseases mediated by ALK5 or ALK4 inhibitors or both.

Abstract translation: 提供了如权利要求1所述的式（I）的2-吡啶基取代的咪唑，其可用于治疗由ALK5或ALK4抑制剂或两者介导的疾病。

公开(公告)号：US20120148693A1

公开(公告)日：2012-06-14

申请号：US13400784

申请日：2012-02-21

Applicant: Chang-Kyun HAN ,  Wie-Jong KWAK ,  Ki Won JOUNG ,  Hun Seung YOO ,  Do Seung KUM ,  Yong-Baik CHO ,  Keun Ho RYU ,  Hae In RHEE ,  Taek Su KIM ,  In Ho JUNG ,  So Yoon LEE ,  Jung Bum YI ,  Joo Hyon KIM ,  Key An UM

Inventor： Chang-Kyun HAN ,  Wie-Jong KWAK ,  Ki Won JOUNG ,  Hun Seung YOO ,  Do Seung KUM ,  Yong-Baik CHO ,  Keun Ho RYU ,  Hae In RHEE ,  Taek Su KIM ,  In Ho JUNG ,  So Yoon LEE ,  Jung Bum YI ,  Joo Hyon KIM ,  Key An UM

IPC: A61K36/716 ,  A61P19/02 ,  A61P19/04

CPC classification number: A61K36/536 ,  A61K36/428 ,  A61K36/716 ,  A61K2300/00

Abstract: The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

Abstract translation: 本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），夏枯草（Prunellae Spica）的植物提取物和迷迭香酸的最佳含量，以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。

公开(公告)号：US20100267817A1

公开(公告)日：2010-10-21

申请号：US12744151

申请日：2008-11-21

Applicant: Woo Jae Jang ,  Joon-Gyo Oh ,  Young Youn Hwang ,  Won Jae Choi ,  Key An Um

Inventor： Woo Jae Jang ,  Joon-Gyo Oh ,  Young Youn Hwang ,  Won Jae Choi ,  Key An Um

IPC: A61K31/337 ,  A61P43/00

CPC classification number: A61K9/19 ,  A61K47/26 ,  A61K47/32

Abstract: The present invention relates to a lyophilized composition with an improved reconstitution time comprising a taxoid and a method thereof. More specifically, the present invention relates to a lyophilized composition with an improved reconstitution time prepared by mixing and dissolving a taxoid; cyclodextrin (CD); a hydrophilic polymer selected from the group consisting of hydroxypropylmethyl CeIIuIoSe (HPMC), polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP); and a bulking agent of saccharides in water for injection; and lyophilizing the mixture, and a method thereof.

Abstract translation: 本发明涉及具有改进的重构时间的冻干组合物，其包含紫杉烷及其方法。 更具体地，本发明涉及通过混合和溶解紫杉烷制备的具有改进的重构时间的冻干组合物; 环糊精（CD）; 选自羟丙基甲基CeIIuIoSe（HPMC），聚乙二醇（PEG）和聚乙烯吡咯烷酮（PVP）的亲水性聚合物; 和糖类在注射用水中的填充剂; 并将混合物冻干，及其方法。