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69 条记录 (耗时 0.031 秒)

    Synthetic methods for preparation of protected proanthocyanidin(s)
    13.
    发明授权
    Synthetic methods for preparation of protected proanthocyanidin(s) 失效
    用于制备被保护的原花色素的合成方法

    公开(公告)号：US06420572B1

    公开(公告)日：2002-07-16

    申请号：US09169554

    申请日：1998-10-09

    申请人： Leo J. Romanczyk, Jr. ,  Alan P. Kozikowski ,  Werner Tueckmantel ,  Marc E. Lippman

    发明人： Leo J. Romanczyk, Jr. ,  Alan P. Kozikowski ,  Werner Tueckmantel ,  Marc E. Lippman

    IPC分类号： C07D31160

    CPC分类号： C07H17/06 ,  A61K31/35 ,  C07D311/32 ,  C07D311/60 ,  C07D311/62

    摘要： A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.

    摘要翻译： 公开了用于生产具有多酚单体单元的多酚低聚物的方法，n为2-18的整数。 该方法包括将被保护的酚羟基的被保护的多酚与C-4官能化的多酚单体的偶联。 受保护的多酚可以是受保护的多酚单体或具有2-17单体单元的被保护的多酚低聚物。 有利地，形成多酚低聚物的多酚单体单元可以是相同或不同的类黄酮化合物。

    Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
    14.
    发明授权
    Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions 失效
    在压片组合物和胶囊填充组合物中使用具有高可可多元酚含量的可可固体

    公开(公告)号：US06297273B1

    公开(公告)日：2001-10-02

    申请号：US08831245

    申请日：1997-04-02

    申请人： Leo J. Romanczyk, Jr.

    发明人： Leo J. Romanczyk, Jr.

    IPC分类号： A61K920

    CPC分类号： C07H17/06 ,  A23G1/32 ,  A23G3/36 ,  A23K20/111 ,  A23K50/40 ,  A61K9/2018 ,  A61K9/2068 ,  A61K9/4858 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/185 ,  A61K45/06 ,  C07D311/32 ,  C07D311/62 ,  C07D311/64 ,  C11B5/0035 ,  A61K2300/00

    摘要： Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula: wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(&agr;)-OH, 3-(&bgr;)-OH, 3-(&agr;)-O-sugar, or 3-(&bgr;)-O-sugar; bonding between adjacent monomers takes place at positions 4, 6 or 8; a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto (the bonding of the additional monomeric unit adjacent to the terminal monomeric unit) is at position 4 and optionally Y=Z=hydrogen; the sugar is optionally substituted with a phenolic moiety, at any position on the sugar, for instance via an ester bond, and pharmaceutically acceptable salts or derivatives thereof (including oxidation products).

    摘要翻译： 公开和要求保护的是可可提取物，化合物，其组合和含有它们的组合物，例如多酚或原花青素，制备此类提取物，化合物和组合物的方法，以及它们的用途，特别是式An的聚合化合物，其中 A是下式的单体：其中n是2至18的整数，使得存在至少一个末端单体单元A和一个或多个另外的单体单元; R是3-（α）-OH， 3-（β）-OH，3-（α）-O-糖或3-（β）-O-糖;相邻单体之间的键合发生在位置4,6或8;附加单体单元的键 位置4具有α或β立体化学; X，Y和Z选自单体单元A，氢和糖，条件是对于至少一个末端单体单元，附加单体单元 单元（其中附加的单体单元与末端单体相邻） 单元）位于第4位并且任选地Y = Z =氢;糖任选被酚部分取代，在糖上的任何位置，例如通过酯键，以及其药学上可接受的盐或其衍生物（包括氧化产物）。

    Methods for treatment using procyanidin topoisomerase inhibitors
    15.
    发明授权
    Methods for treatment using procyanidin topoisomerase inhibitors 失效
    使用原花青素拓扑异构酶抑制剂治疗的方法

    公开(公告)号：US6156791A

    公开(公告)日：2000-12-05

    申请号：US198551

    申请日：1998-11-23

    申请人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    发明人： Leo J. Romanczyk, Jr. ,  John F. Hammerstone, Jr. ,  Margaret M. Buck

    IPC分类号： A23L1/30 ,  A23G1/02 ,  A23G1/30 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7048 ,  A61K31/78 ,  A61K36/00 ,  A61K36/18 ,  A61K36/185 ,  A61P35/00 ,  C07D311/62 ,  C07D311/78 ,  A01N43/16

    CPC分类号： A61K31/78 ,  A23L33/105 ,  A61K31/353 ,  A61K36/185 ,  C07D311/62

    摘要： Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins-and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.

    摘要翻译： 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物以及用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。