公开(公告)号：US06413267B1

公开(公告)日：2002-07-02

申请号：US09370315

申请日：1999-08-09

Applicant: Roger J. Dumoulin-White ,  Lothar Lilge ,  Robert A. Weersink

Inventor： Roger J. Dumoulin-White ,  Lothar Lilge ,  Robert A. Weersink

IPC: A61N5006

CPC classification number: A61N5/0616 ,  A61B2017/00066 ,  A61N2005/0644 ,  A61N2005/0659 ,  A61N2005/067

Abstract: A method is provided for treating a patient having a disorder, wherein the method includes irradiating a tissue surface of the patient with at least one laser beam, automatically monitoring the tissue, and automatically controlling the at least one laser beam to adjust and/or terminate the treatment in a therapeutically effective manner. The method noninvasively determines in real-time the irradiance and/or radiant exposure of a target tissue at a predetermined depth below the tissue surface by detecting the radial dependence of light remitted from the tissue surface. Preferably, the method employs a near-infrared light laser beam and a visible laser light beam in combination. An apparatus for performing the method is also provided.

Abstract translation: 提供了一种用于治疗患有病症的患者的方法，其中所述方法包括用至少一个激光束照射患者的组织表面，自动监测组织，以及自动控制所述至少一个激光束以调节和/或终止 治疗以治疗有效的方式。 该方法通过检测从组织表面排出的光的径向依赖性来无损地确定组织表面下方预定深度处的目标组织的辐照度和/或辐射暴露。 优选地，该方法组合使用近红外光激光束和可见激光束。 还提供了一种用于执行该方法的装置。

公开(公告)号：US6154282A

公开(公告)日：2000-11-28

申请号：US374535

申请日：1999-08-16

Applicant: Lothar Lilge ,  Peter S. Pennefather ,  Stephen M. Ross ,  Cha-Min Tang ,  Kai Zhang

Inventor： Lothar Lilge ,  Peter S. Pennefather ,  Stephen M. Ross ,  Cha-Min Tang ,  Kai Zhang

IPC: G01N21/64 ,  G02B21/00 ,  G02B21/06 ,  H01L33/64

CPC classification number: G02B21/0096

Abstract: Apparatus for exciting a fluorescent or phosphorescent molecule applied to a specimen in a microscope, the molecule having a known excitation wavelength, comprises a semiconductor light source capable of emitting an output light within a preselected wavelength band correlated with the excitation wavelength of the molecule, an electronic controller coupled to the light source for controlling the intensity of the output light, and an optical system for converting the output light into an excitation beam having a pre-selected distribution of light flux suitable for illuminating the specimen. The semiconductor light source is preferably a light emitting diode or superluminescent diode. The subject invention provides for a fluorescence excitation illuminator having a long lifetime and relatively low cost. Intensity modulation or attenuation can be achieved electronically, without the need for shutters.

Abstract translation: 用于激发在显微镜中施加到样品上的荧光或磷光分子的装置，具有已知激发波长的分子包括能够发射与分子的激发波长相关的预选波长带内的输出光的半导体光源， 耦合到光源的电子控制器，用于控制输出光的强度;以及光学系统，用于将输出光转换成具有预先选择的适于照射样本的光通量分布的激发光束。 半导体光源优选为发光二极管或超发光二极管。 本发明提供了具有长寿命和相对较低成本的荧光激发照明器。 强度调制或衰减可以电子地实现，而不需要百叶窗。

公开(公告)号：US5483958A

公开(公告)日：1996-01-16

申请号：US188325

申请日：1994-01-25

Applicant: Glenn N. Merberg ,  Lothar Lilge

Inventor： Glenn N. Merberg ,  Lothar Lilge

IPC: A61N5/06 ,  G01J1/58 ,  A61B5/00

CPC classification number: A61N5/062 ,  A61N5/0601 ,  G01J1/58 ,  A61B2017/00066

Abstract: A solid-state fluorescent dosimeter for monitoring therapy irradiation dosage during a photodynamic therapy procedure. The solid-state fluorescent dosimeter includes an optical fiber -having a distal end and a proximal end, and a solid-state fluorescent tip attached to the proximal end of the optical fiber. The solid-state fluorescent tip includes a fluorescent material which emits fluorescence when exposed to non-ionizing radiation in the visible or near infrared range. The solid-state fluorescent tip has a sufficient length so as ensure isotropic response characteristics to the non-ionizing radiation regardless of the orientation or alignment of the solid-state fluorescent tip relative to the irradiation source.

Abstract translation: 一种用于在光动力学治疗过程中监测治疗照射剂量的固态荧光剂量计。 固态荧光剂量计包括具有远端和近端的光纤和固定在光纤的近端的固态荧光尖端。 固态荧光尖端包括当暴露于可见光或近红外范围内的非电离辐射时发出荧光的荧光材料。 固态荧光尖端具有足够的长度，以确保与非电离辐射的各向同性响应特性，而不管固态荧光尖端相对于照射源的取向或取向如何。

公开(公告)号：US5275160A

公开(公告)日：1994-01-04

申请号：US641152

申请日：1991-01-14

Applicant: Lothar Lilge ,  Brian C. Wilson ,  Thomas Haw

Inventor： Lothar Lilge ,  Brian C. Wilson ,  Thomas Haw

IPC: G01N21/64 ,  A61B5/00

CPC classification number: G01N21/7703 ,  G01N21/6428 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2021/7786

Abstract: The invention features a probe for radiance dosimetry. The probe includes a tip portion containing a fluorescent dye connected to a translucent spacer element.

Abstract translation: 本发明的特征在于用于辐射剂量测定的探针。 探针包括含有连接到半透明间隔元件的荧光染料的尖端部分。