公开(公告)号：US12127957B2

公开(公告)日：2024-10-29

申请号：US17298674

申请日：2019-11-28

Applicant: Universiteit Gent ,  IMEC VZW

Inventor： Rik Verplancke ,  Jan Vanfleteren

IPC: A61F2/86 ,  A61N5/06

CPC classification number: A61F2/86 ,  A61N5/0601 ,  A61N5/0622 ,  A61F2210/0014 ,  A61F2210/0057 ,  A61F2220/005 ,  A61F2250/006 ,  A61N2005/0602 ,  A61N2005/0632 ,  A61N2005/0652

Abstract: The present invention relates to a method for integrating an electronic circuit in or on a medical stent. The method comprises obtaining (101) a deformable medical stent (21) in a substantially planar shape, in which the deformable medical stent is adapted for being deployed in a substantially cylindrical shape in the body. The method also comprises attaching (104) a deformable electronic circuit (22) onto the deformable medical stent in the planar shape thereby forming a deformable hybrid structure. The method also comprises shaping (107) said hybrid structure into the cylindrical shape.

公开(公告)号：US20240307705A1

公开(公告)日：2024-09-19

申请号：US18546639

申请日：2022-02-21

Applicant: Case Western Reserve University

Inventor： Michael MOFFITT ,  Stephen LEWIS ,  Michael JENKINS

IPC: A61N5/06

CPC classification number: A61N5/0622 ,  A61N5/0601

Abstract: Subcutaneous photobiomodulation (PBM) is described for treatment of one or more medical conditions, including pulmonary fibrosis, an abnormality in upper airway function, hypertension, congestive heart failure, pulmonary hypertension, etc. The system includes a light source that can generate light inside the body (subcutaneously), a light transmission medium to transmit the light to an emitter, and the emitter sized and shaped to deliver the light directly to a target area associated with pulmonary fibrosis, an abnormality in upper airway function, hypertension, congestive heart failure, and/or pulmonary hypertension.

公开(公告)号：US20240299766A1

公开(公告)日：2024-09-12

申请号：US18665513

申请日：2024-05-15

Applicant: The Medical College of Wisconsin, Inc.

Inventor： Nicole Lohr ,  Michael Salinger

IPC: A61N5/06 ,  A61B17/00 ,  A61B18/00 ,  A61B18/24 ,  A61B90/00

CPC classification number: A61N5/0601 ,  A61B18/24 ,  A61N5/0613 ,  A61B2017/0019 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2090/049 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/0663

Abstract: Reperfusion injury is limited during endovascular therapies (e.g., revascularization and/or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R/NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R/NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy.

公开(公告)号：US12076579B2

公开(公告)日：2024-09-03

申请号：US17433768

申请日：2020-02-27

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Ronald A. Rudder ,  Joseph H. Simmons

IPC: A61N5/06 ,  A61K35/12 ,  A61K41/00 ,  A61N5/067 ,  C09J133/08 ,  C09K11/02 ,  C09K11/59 ,  C09K11/76 ,  C09K11/77 ,  C12N15/01 ,  F21K2/00 ,  F21S11/00 ,  F21V9/40 ,  H01J45/00 ,  H01L23/00 ,  H01L31/0352 ,  H01L31/054 ,  H01L31/055 ,  H01L31/06

CPC classification number: A61N5/0625 ,  A61K35/12 ,  A61K41/00 ,  A61K41/0057 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/067 ,  C09J133/08 ,  C09K11/025 ,  C09K11/595 ,  C09K11/76 ,  C09K11/7701 ,  C09K11/7792 ,  C12N15/01 ,  F21K2/00 ,  F21S11/007 ,  F21V9/40 ,  H01J45/00 ,  H01L24/29 ,  H01L24/83 ,  H01L31/035281 ,  H01L31/054 ,  H01L31/06 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663 ,  H01L31/055 ,  H01L2224/2919 ,  H01L2224/29393 ,  H01L2224/8322 ,  H01L2224/83855

Abstract: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.

公开(公告)号：US12076577B2

公开(公告)日：2024-09-03

申请号：US17543304

申请日：2021-12-06

Applicant: Prometheus Therapeutics Inc.

Inventor： Baruch B. Lieber ,  John A. Rose

IPC: A61N5/06 ,  A61B1/00 ,  A61B1/05 ,  A61B1/313 ,  A61B17/02 ,  A61B17/12 ,  A61B18/24 ,  A61F2/90 ,  A61M25/00 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61B90/00 ,  A61F2/82

CPC classification number: A61N5/0601 ,  A61B1/00045 ,  A61B1/00087 ,  A61B1/05 ,  A61B1/3137 ,  A61B17/0218 ,  A61B17/12113 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/12181 ,  A61B18/24 ,  A61F2/90 ,  A61M25/00 ,  A61N5/062 ,  A61B2017/00292 ,  A61B2017/00557 ,  A61B2017/00778 ,  A61B2017/00907 ,  A61B2017/0225 ,  A61B17/12118 ,  A61B17/12136 ,  A61B17/12186 ,  A61B2017/22067 ,  A61B2018/00029 ,  A61B2018/00404 ,  A61B2018/00416 ,  A61B2018/00589 ,  A61B2018/00982 ,  A61B2018/2238 ,  A61B2018/2261 ,  A61B90/361 ,  A61B2217/007 ,  A61F2002/823 ,  A61F2002/826 ,  A61N2005/0602 ,  A61N2005/0659 ,  A61N2005/0662

Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

公开(公告)号：US12029914B2

公开(公告)日：2024-07-09

申请号：US17148133

申请日：2021-01-13

Applicant: KNOW Bio, LLC

Inventor： Nathan Stasko ,  David T. Emerson ,  Adam Cockrell ,  F. Neal Hunter ,  Michael John Bergmann ,  Rebecca McDonald ,  Nicholas William Medendorp, Jr. ,  Gerald H. Negley ,  Katelyn P. Reighard

IPC: A61N5/06 ,  H01L27/15

CPC classification number: A61N5/0613 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/0624 ,  H01L27/15 ,  A61N2005/0611 ,  A61N2005/0626 ,  A61N2005/0647 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663

Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.

公开(公告)号：US20240220094A1

公开(公告)日：2024-07-04

申请号：US18397740

申请日：2023-12-27

Applicant: Boston Scientific Neuromodulation Corporation

Inventor： Joshua Dale Howard ,  Michael A. Moffitt ,  Changfang Zhu

IPC: G06F3/04847

CPC classification number: G06F3/04847 ,  A61N5/0601

Abstract: An optical modulation system includes a user interface including a plurality of user-selectable controls to select or adjust values for each of a plurality of modulation parameters and estimating a modulation dosage or irradiance at a target based on, at least, the target, a location of an optical modulation lead, values of the modulation parameters, and estimated light attenuation by tissue between the optical modulation lead and the target. An optical modulation system can limit selection of the value of at least one of the modulation parameters by at least one of a) an estimation of a modulation dosage at the target or b) an estimation of a dosage, temperature change, temperature, heating, or delivering energy at non-target issue.

公开(公告)号：US12023507B2

公开(公告)日：2024-07-02

申请号：US16591874

申请日：2019-10-03

Applicant: Lawrence Livermore National Security, LLC

Inventor： Susant Patra ,  Razi-Ul Muhammad Haque ,  Komal Kampasi

IPC: A61N5/06 ,  A61N1/36 ,  A61N1/372 ,  F21V8/00 ,  G02B6/12 ,  G02B6/28 ,  G02B6/42 ,  G02B6/43 ,  H01S5/183 ,  A61B18/00 ,  A61N5/067 ,  G02F1/00

CPC classification number: A61N1/37247 ,  A61N1/36125 ,  A61N1/37205 ,  A61N5/0601 ,  A61N5/0622 ,  G02B6/0008 ,  G02B6/12 ,  G02B6/4293 ,  G02B6/43 ,  H01S5/183 ,  A61B2018/00636 ,  A61B2562/028 ,  A61B2562/04 ,  A61B2562/228 ,  A61N5/067 ,  G02F1/0018

Abstract: An opto-electronic probe system is disclosed. The probe system has a probe element including at least one microelectrode, with the probe element being implantable in tissue of an anatomy to receive electrical signals generated within the anatomy. A subsystem is included for at least one of generating excitation signals to be used in stimulating the anatomy, or for receiving electrical signals received from the anatomy. An interface portion is included which is in communication with the subsystem for communicating at least one of electrical signals or optical signals indicative of the electrical signals received by the microelectrode.

公开(公告)号：US11998758B2

公开(公告)日：2024-06-04

申请号：US17148133

申请日：2021-01-13

Applicant: KNOW Bio, LLC

Inventor： Nathan Stasko ,  David T. Emerson ,  Adam Cockrell ,  F. Neal Hunter ,  Michael John Bergmann ,  Rebecca McDonald ,  Nicholas William Medendorp, Jr. ,  Gerald H. Negley ,  Katelyn P. Reighard

IPC: A61N5/06 ,  H01L27/15

CPC classification number: A61N5/0613 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/0624 ,  H01L27/15 ,  A61N2005/0611 ,  A61N2005/0626 ,  A61N2005/0647 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663

Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.

公开(公告)号：US20240176057A1

公开(公告)日：2024-05-30

申请号：US18384669

申请日：2023-10-27

Applicant: Proterial, Ltd.

Inventor： Kota TACHIBANA ,  Ryuta TAKAHASHI ,  Seiji KOJIMA

IPC: F21V8/00 ,  A61N5/06

CPC classification number: G02B6/001 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063

Abstract: A peripheral surface-emitting linear light guide is provided with an optical fiber including a core, an outer peripheral surface of which is exposed from a cladding at one end in a longitudinal direction, and a light-scattering member that covers an entire periphery of the outer peripheral surface of the core in an exposed portion over a predetermined axial length range. The light emitted from the outer peripheral surface of the core is scattered and radiated by the light-scattering member. The light-scattering member includes a light transmissive base material having a higher refractive index than the core and light-scattering particles that scatter the light incident on the base material, and the light-scattering particles are dispersed and mixed in a certain proportion throughout the base material. At least a portion of the light-scattering member in the longitudinal direction is an increasing portion whose thickness increases gradually toward a tip side of the core.