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公开(公告)号：US06437100B1
公开(公告)日：2002-08-20
申请号：US09642514
申请日：2000-08-21
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
IPC: C07K1628
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US6136559A
公开(公告)日：2000-10-24
申请号：US167354
申请日：1998-10-07
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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13.发明授权Methods of use of DNA encoding a human histamine receptor of the H3 subtype 有权使用编码H3亚型的人组胺受体的DNA的方法公开(公告)号：US07179604B2
公开(公告)日：2007-02-20
申请号：US10727021
申请日：2003-12-02
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US20070020655A1
公开(公告)日：2007-01-25
申请号：US11422056
申请日：2006-06-02
Applicant: Mark Erlander , Xiao-Jun Ma
Inventor： Mark Erlander , Xiao-Jun Ma
CPC classification number: G16B40/00 , C12Q1/6886 , C12Q2600/112 , G16B25/00
Abstract: The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.
Abstract translation: 本发明提供了使用基因表达测量法在临床环境中从受试者获得的样品中分类或鉴定肿瘤的方法，例如在福尔马林固定的石蜡包埋（FFPE）样品的情况下。
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公开(公告)号：US20060263806A1
公开(公告)日：2006-11-23
申请号：US11381353
申请日：2006-05-02
Applicant: Xiao-Jun Ma , Dennis Sgroi , Mark Erlander
Inventor： Xiao-Jun Ma , Dennis Sgroi , Mark Erlander
CPC classification number: G01N33/57496 , C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158 , G01N33/57415
Abstract: Methods and compositions are provided for the detection of breast cancer based upon the identification of three biomarkers for non-normal breast cells. The biomarkers were identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer. Two biomarkers display increased expression in non-normal cells while the third biomarker displays decreased expression in non-normal cells.
Abstract translation: 基于鉴定非正常乳腺细胞的三种生物标志物，提供了用于检测乳腺癌的方法和组合物。 基于来自独立乳腺癌病例的参考乳腺组织样品的多次取样来鉴定生物标志物。 两个生物标志物在非正常细胞中显示出增加的表达，而第三个生物标志物在非正常细胞中显示出降低的表达。
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Patent Agency Ranking
公开(公告)号：US20060088851A1
公开(公告)日：2006-04-27
申请号：US11145061
申请日：2005-06-03
Applicant: Mark Erlander , Dennis Sgroi , Xiao-Jun Ma
Inventor： Mark Erlander , Dennis Sgroi , Xiao-Jun Ma
IPC: C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6827 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154
Abstract: This invention relates to the detection of increased expression from the HoxB13 (homeobox B13) gene as indicative of an invasive or metastatic cancer phenotype. The invention provides methods of detecting the level of expression from the HoxB13 gene, optionally in combination with nodal status, as an indicator of the invasive or metastatic phenotype as well as increased cellular migration and/or mobility. The invention also provides for the measurement of expression from the HoxB13 gene to assist in the determination of patient prognosis as well as clinical diagnosis and treatment.
Abstract translation: 本发明涉及从HoxB13（同源盒B13）基因增加的表达的检测，指示侵袭性或转移性癌症表型。 本发明提供了检测来自HoxB13基因的表达水平的方法，任选地与结节状态组合，作为侵袭性或转移表型的指标以及增加的细胞迁移和/或迁移率。 本发明还提供了来自HoxB13基因的表达的测量以帮助确定患者的预后以及临床诊断和治疗。
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公开(公告)号：US20050239079A1
公开(公告)日：2005-10-27
申请号：US10727100
申请日：2003-12-02
Applicant: Mark Erlander , Xiao-Jun Ma , Dennis Sgroi
Inventor： Mark Erlander , Xiao-Jun Ma , Dennis Sgroi
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
Abstract: Methods and compositions are provided for the identification of expression signatures in ER+ breast cancer cases, where the signatures correlate with responsiveness, or lack thereof, to tamoxifen treatment. The signature profiles are identified based upon sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for predicting the efficacy of treating a subject with ER+ breast cancer with tamoxifen. Additional methods and compositions are provided for predicting tamoxifen responsiveness in cases of ER+ breast cancer by use of three biomarkers. Two biomarkers display increased expression correlated with tamoxifen response while the third biomarker displays decreased expression correlated with tamoxifen response.
Abstract translation: 提供方法和组合物用于鉴定ER +乳腺癌病例中的表达标志，其中签名与他莫昔芬治疗的反应性或缺乏相关。 基于来自乳腺癌独立病例的参考乳腺组织样本的抽样来鉴定特征谱，并提供可靠的一组分子标准，用于预测使用他莫昔芬治疗患有ER +乳腺癌的受试者的功效。 提供了另外的方法和组合物，用于通过使用三种生物标志物来预测ER +乳腺癌患者中的他莫昔芬反应性。 两种生物标志物显示与他莫昔芬反应相关的增加的表达，而第三种生物标志物显示与他莫昔芬反应相关的降低的表达。
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公开(公告)号：US20050164342A1
公开(公告)日：2005-07-28
申请号：US10641149
申请日：2003-08-15
Applicant: Allan Tobin , Mark Erlander , Daniel Kaufman
Inventor： Allan Tobin , Mark Erlander , Daniel Kaufman
IPC: A61K38/00 , A61K38/51 , A61K51/00 , A61P3/10 , A61P21/02 , A61P37/02 , C12N1/21 , C12N9/88 , C12N11/00 , C12N15/09 , C12N15/60 , C12Q1/527 , C12Q1/68 , C12R1/01 , G01N33/53 , G01N33/564 , G01N33/573 , C07H21/04 , C07K16/40
CPC classification number: C12Y401/01015 , A61K38/00 , C12N9/88 , G01N33/564 , G01N2800/042
Abstract: cDNA molecules coding for GAD65 polypeptide. The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD65 which encode at least one epitope for autoantibodies to GAD65. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD65. The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for GAD65. In another embodiment, the invention provides for the detection of autoantibodies to GAD65 using the GAD65 polypeptides coded for by the cDNA molecules of the invention.
Abstract translation: 编码GAD 65多肽的cDNA分子。 本发明提供cDNA分子，其包含编码至少一个表位用于自身抗体至GAD 65的GAD 65 cDNA的一部分cDNA序列。 本发明还提供能够复制和表达的克隆载体，其包含编码GAD 65的cDNA分子。 本发明还提供了用载体转化的宿主，其具有编码GAD 65的cDNA分子。 在另一个实施方案中，本发明提供使用本发明的cDNA分子编码的GAD 65多肽来检测GAD 65的自身抗体。
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公开(公告)号：US20050084897A1
公开(公告)日：2005-04-21
申请号：US10985156
申请日：2004-11-10
Applicant: Adrienne Dubin , Arne Huvar , Charles Glass , Mark Erlander
Inventor： Adrienne Dubin , Arne Huvar , Charles Glass , Mark Erlander
IPC: G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/04 , A61P29/00 , A61P31/22 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , G01N33/15 , C12Q1/68 , C07H21/04
CPC classification number: C07K14/705 , A61K38/00
Abstract: DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 编码人VR1受体的DNA已被克隆和表征。 重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US20060286579A1
公开(公告)日：2006-12-21
申请号：US11422045
申请日：2006-06-02
Applicant: Mark Erlander , Xiao-Jun Ma
Inventor： Mark Erlander , Xiao-Jun Ma
CPC classification number: C12Q1/6876 , C12Q2600/158
Abstract: This invention provides gene sequence identities and methods for the determination of cellular gene expression and the comparison of expression levels between different gene sequences and between different cells. The gene sequences may be used as reference, normalization, or “housekeeping” gene sequences, the expression of which remains consistent in individual cells, even under different conditions, as well as among cells from different samples and origins.
Abstract translation: 本发明提供用于确定细胞基因表达的基因序列同一性和方法以及不同基因序列之间和不同细胞之间的表达水平的比较。 基因序列可用作参考，归一化或“家务”基因序列，其表达在单个细胞中甚至在不同条件下以及来自不同样品和来源的细胞中保持一致。
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