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    Peptides and uses
    11.
    发明授权
    Peptides and uses 有权
    多肽和用途

    公开(公告)号：US09096682B2

    公开(公告)日：2015-08-04

    申请号：US13879422

    申请日：2011-10-17

    Applicant: Mark Isalan ,  Mireia Garriga-Canut

    Inventor： Mark Isalan ,  Mireia Garriga-Canut

    IPC: A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07K14/47

    CPC classification number: C07K14/4703 ,  A61K38/00 ,  A61K38/1709 ,  A61K48/00 ,  Y02A50/411

    Abstract: Disclosed herein are zinc finger peptides having at least 4 zinc finger domains, such as 6, 11, 12 or 18 zinc finger domains. The zinc finger peptides may be fused to effector domains for modulating gene expression. Zinc finger peptides of the invention are useful for targeting trinucleotide-repeat sequences in mutant genes and may have applications in gene therapy. The zinc finger peptides may have nucleic acid recognition sequences according to SEQ ID NO: 101. Also disclosed are methods for constructing poly-zinc finger peptides having arrays of at least 8 zinc finger domains, along with zinc finger frameworks that may be useful for selecting zinc finger peptides from libraries.

    Abstract translation: 本文公开了具有至少4个锌指结构域的锌指肽，例如6,11,12或18个锌指结构域。 锌指肽可以融合到效应域以调节基因表达。 本发明的锌指肽可用于靶向突变基因中的三核苷酸重复序列，并且可能在基因治疗中具有应用。 锌指肽可以具有根据SEQ ID NO：101的核酸识别序列。还公开了构建具有至少8个锌指结构域的阵列的多 - 锌指肽的方法，以及可用于选择的锌指骨架 来自文库的锌指肽。

    PEPTIDES AND USES
    12.
    发明申请
    PEPTIDES AND USES 有权
    肽和用途

    公开(公告)号：US20130336947A1

    公开(公告)日：2013-12-19

    申请号：US13879422

    申请日：2011-10-17

    Applicant: Mark Isalan ,  Mireia Garriga-Canut

    Inventor： Mark Isalan ,  Mireia Garriga-Canut

    IPC: C07K14/47

    CPC classification number: C07K14/4703 ,  A61K38/00 ,  A61K38/1709 ,  A61K48/00 ,  Y02A50/411

    Abstract: Disclosed herein are zinc finger peptides having at least 4 zinc finger domains, such as 6, 11, 12 or 18 zinc finger domains. The zinc finger peptides may be fused to effector domains for modulating gene expression. Zinc finger peptides of the invention are useful for targeting trinucleotide-repeat sequences in mutant genes and may have applications in gene therapy. The zinc finger peptides may have nucleic acid recognition sequences according to SEQ ID NO: 101. Also disclosed are methods for constructing poly-zinc finger peptides having arrays of at least 8 zinc finger domains, along with zinc finger frameworks that may be useful for selecting zinc finger peptides from libraries.

    Abstract translation: 本文公开了具有至少4个锌指结构域的锌指肽，例如6,11,12或18个锌指结构域。 锌指肽可以融合到效应域以调节基因表达。 本发明的锌指肽可用于靶向突变基因中的三核苷酸重复序列，并且可能在基因治疗中具有应用。 锌指肽可以具有根据SEQ ID NO：101的核酸识别序列。还公开了构建具有至少8个锌指结构域的阵列的多 - 锌指肽的方法，以及可用于选择的锌指骨架 来自文库的锌指肽。

    OBLIGATE HETERODIMER MEGANUCLEASES AND USES THEREOF
    13.
    发明申请
    OBLIGATE HETERODIMER MEGANUCLEASES AND USES THEREOF 审中-公开
    使用疏水剂的疏水剂及其用途

    公开(公告)号：US20100167357A1

    公开(公告)日：2010-07-01

    申请号：US12449329

    申请日：2008-01-31

    Applicant: Emmanuel Fajardo Sanchez ,  Sylvestre Grizot ,  Mark Isalan ,  Luis Serrand Pubul ,  Francois Stricher

    Inventor： Emmanuel Fajardo Sanchez ,  Sylvestre Grizot ,  Mark Isalan ,  Luis Serrand Pubul ,  Francois Stricher

    IPC: C12N15/64 ,  C12N9/16 ,  C12N1/19 ,  C12N15/63 ,  C07H21/04

    CPC classification number: C12N9/22 ,  A61K38/00

    Abstract: An obligate heterodimer meganuclease consisting of a first and a second monomer, deriving from two different homodimeric LAGLIDADG (SEQ ID NO: 66) endonuclease monomers (parent monomers), and having at least one pair of mutations interesting corresponding residues of said parent monomers which make an intermolecular interaction between the two monomers of each parent homodimeric LAGLIDADG (SEQ ID NO: 66) endonuclease, a vector encoding said meganuclease, a cell, an animal or a plant modified by said vector and the use of said meganuclease and derived products for molecular biology, genome engineering and genome therapy.

    Abstract translation: 衍生自两种不同同二聚体LAGLIDADG（SEQ ID NO：66）核酸内切酶单体（母体单体）的第一和第二单体的专一异源二聚体大范围核酸酶，并且具有至少一对突变引起所述母体单体有趣的相应残基， 每个亲代同源二聚体LAGLIDADG（SEQ ID NO：66）核酸内切酶的两种单体之间的分子间相互作用，编码所述大范围核酸酶的细胞，由所述载体修饰的细胞，动物或植物的载体以及所述大范围核酸酶和衍生产物用于分子 生物学，基因组工程和基因组治疗。

    Nucleic acid binding polypeptide library
    16.
    发明授权
    Nucleic acid binding polypeptide library 有权
    核酸结合多肽文库

    公开(公告)号：US07700523B2

    公开(公告)日：2010-04-20

    申请号：US11514671

    申请日：2006-09-01

    Applicant: Yen Choo ,  Aaron Klug ,  Mark Isalan

    Inventor： Yen Choo ,  Aaron Klug ,  Mark Isalan

    IPC: C40B30/04 ,  C07K1/00

    CPC classification number: C40B40/02 ,  C07K1/047 ,  C07K14/4702 ,  C12N15/1037

    Abstract: The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which has been at least partially randomized, and which polypeptide may be assembled after selection to form a multifinger zinc finger polypeptide.

    Abstract translation: 本发明涉及一种锌指多肽文库，其中每个多肽包含至少部分随机化的多于一个锌指，以及编码重叠锌指多肽的一组锌指多肽文库，每个多肽包含多于一个锌 手指至少部分随机化，并且哪些多肽可以在选择后组装以形成多角蛋白锌指多肽。

    Nucleic acid binding polypeptide library
    18.
    发明申请
    Nucleic acid binding polypeptide library 有权
    核酸结合多肽文库

    公开(公告)号：US20070009948A1

    公开(公告)日：2007-01-11

    申请号：US11514671

    申请日：2006-09-01

    Applicant: Yen Choo ,  Aaron Klug ,  Mark Isalan

    Inventor： Yen Choo ,  Aaron Klug ,  Mark Isalan

    IPC: C40B30/06 ,  C40B40/10

    CPC classification number: C40B40/02 ,  C07K1/047 ,  C07K14/4702 ,  C12N15/1037

    Abstract: The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which has been at least partially randomized, and which polypeptide may be assembled after selection to form a multifinger zinc finger polypeptide.

    Abstract translation: 本发明涉及一种锌指多肽文库，其中每个多肽包含至少部分随机化的多于一个锌指，以及编码重叠锌指多肽的一组锌指多肽文库，每个多肽包含多于一个锌 手指至少部分随机化，并且哪些多肽可以在选择后组装以形成多角蛋白锌指多肽。

    Nucleic acid binding proteins
    20.
    发明授权
    Nucleic acid binding proteins 有权
    核酸结合蛋白

    公开(公告)号：US06746838B1

    公开(公告)日：2004-06-08

    申请号：US09424487

    申请日：2000-02-29

    Applicant: Yen Choo ,  Aaron Klug ,  Mark Isalan

    Inventor： Yen Choo ,  Aaron Klug ,  Mark Isalan

    IPC: C12Q168

    CPC classification number: C40B40/02 ,  C07K1/047 ,  C07K14/4702 ,  C12N15/1037

    Abstract: The invention provides a method for preparing a nucleic acid binding protein of the Cys2-His2 zinc finger class capable of binding to a nucleic acid quadruplet in a target nucleic acid sequence, wherein binding to base 4 of the quadruplet by an alpha-helical zinc finger nucleic acid binding motif in the protein is determined as follows: if base 4 in the quadruplet is A, then position +6 in the alpha-helix is Glu, Asn or Val; if base 4 in the quadruplet is C, then position +6 in the alpha-helix is Ser, Thr, Val, Ala, Glu or Asn.

    Abstract translation: 本发明提供了一种制备能够与目标核酸序列中的核酸四联体结合的Cys2-His2锌指类的核酸结合蛋白的方法，其中通过α-螺旋锌指结合四联体的碱基4 蛋白质中的核酸结合基序如下测定：如果四联体中的碱基为A，则α-螺旋中的位置+6为Glu，Asn或Val; 如果四联体中的碱基为C，则α-螺旋中的位置+6是Ser，Thr，Val，Ala，Glu或Asn。

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