公开(公告)号：US20160130559A1

公开(公告)日：2016-05-12

申请号：US14897262

申请日：2014-06-13

Applicant: ORGENESIS LTD. ,  TEL HASHOMER-MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.

Inventor： SARAH FERBER

IPC: C12N5/071 ,  A61K35/38 ,  A61K38/17

CPC classification number: C12N5/0676 ,  A61K35/38 ,  A61K35/407 ,  A61K38/1709 ,  C12N2501/60 ,  C12N2506/14 ,  C12N2510/00 ,  C12N2710/10343 ,  C12N2830/30

Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.

Abstract translation: 本发明提供了顺序和时间上调控胰腺转录因子诱导非胰腺细胞沿胰腺细胞谱系转分化和成熟的方法。 本发明还提供了用于鉴定，分离和富集转分化易感细胞的方法和用于治疗退行性胰腺疾病如糖尿病的方法。