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20 条记录 (耗时 0.027 秒)

    Methods for detecting genetic and phenotypic biomarkers of urothelial carcinoma and treatment thereof
    12.
    发明授权
    Methods for detecting genetic and phenotypic biomarkers of urothelial carcinoma and treatment thereof 有权

    公开(公告)号：US10131955B2

    公开(公告)日：2018-11-20

    申请号：US15159359

    申请日：2016-05-19

    申请人： Pacific Edge Limited

    发明人： David Darling ,  James Miller Suttie ,  Mark Dalphin ,  Laimonis Kavalieris ,  Paul O'Sullivan ,  Satish Kumar

    IPC分类号： G01N33/48 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/50

    摘要： New methods for identifying patents with hematuria who are at low risk of having urothelial cancer (UC) include combining selected phenotypic variables with levels of genotypic expression into a new metric, the “G+P INDEX.” The G+P INDEX combines age, sex, smoking history, presence of hematuria, and frequency of hematuria with genotypic expression of the genetic markers, MDK, CDC2, HOXA13, IGFBP5, and optionally IL8Rb, then determining of the G+P INDEX value obtained for a patient is within one of three groups, either: (1) at High Risk of UC, (2) at Risk of UC, or (3) at Low Risk of UC. For groups 1 and 2, further clinical and laboratory work up is indicated, and patients in group 3 are monitored periodically to determine the need for further clinical workup. Using the G+P INDEX can save substantial time, effort, and funds by avoiding unnecessary medical diagnostic procedures for patients at Low Risk of UC.

    TEST KITS
    14.
    发明申请
    TEST KITS 审中-公开
    测试工具

    公开(公告)号：US20160068916A1

    公开(公告)日：2016-03-10

    申请号：US14860024

    申请日：2015-09-21

    申请人： Pacific Edge Limited

    发明人： Hjalmar Nekarda ,  Jan Friederichs ,  Bernhard Holzmann ,  Robert Rosenberg ,  Anthony Edmund Reeve ,  Michael Alan Black ,  John Lindsay McCall ,  Yu-Hsin Lin ,  Robert Craig Pollock

    IPC分类号： C12Q1/68

    摘要： This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer, based on signatures of genetic markers. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a treatment modality for a cancer patient, among other methods as well as kits and devices for carrying out these methods.

    摘要翻译： 本发明涉及预后特征，以及用于确定患者中癌症预后的组合物和方法，特别是用于结肠直肠癌。 具体地，本发明涉及基于遗传标记的签名的遗传标记物用于预测癌症预后如结肠直肠癌的用途。 在各个方面，本发明涉及预测癌症患者的长期存活的可能性的方法，确定癌症患者的治疗方案的方法，以及为癌症患者制备治疗方式的方法 方法以及用于执行这些方法的套件和设备。

    Markers for Detection of Gastric Cancer
    17.
    发明申请
    Markers for Detection of Gastric Cancer 有权

    公开(公告)号：US20170292956A1

    公开(公告)日：2017-10-12

    申请号：US15096943

    申请日：2016-04-12

    申请人： Pacific Edge Limited

    发明人： Parry John Guilford

    IPC分类号： G01N33/574 ,  G06F19/20 ,  C12Q1/68

    CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/47 ,  G01N2333/4725 ,  G06F19/20

    摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors.

    PCR-Based Assays for Nucleic Acids
    20.
    发明申请
    PCR-Based Assays for Nucleic Acids 审中-公开
    基于PCR的核酸测定

    公开(公告)号：US20160369355A1

    公开(公告)日：2016-12-22

    申请号：US15252869

    申请日：2016-08-31

    申请人： Pacific Edge Limited

    发明人： Parry John Guilford ,  Andrew John Holyoake

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57446

    摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.

    摘要翻译： 肿瘤的早期检测是肿瘤患者（包括胃肿瘤）存活的主要决定因素。 GTM基因家族的成员可能在胃肿瘤组织和其他肿瘤组织中过度表达，因此可用作胃癌和其他类型癌症的标志物。 GTM蛋白可以从癌细胞释放，并且可以在血清和/或其它液体中达到足够高的浓度以允许其检测。 因此，用于GTM检测和定量的方法和检测试剂盒可为胃癌的诊断提供有价值的工具。