公开(公告)号：US10689707B2

公开(公告)日：2020-06-23

申请号：US15252869

申请日：2016-08-31

申请人： Pacific Edge Limited

发明人： Parry John Guilford ,  Andrew John Holyoake

IPC分类号： C12Q1/6886 ,  G01N33/574 ,  C12Q1/6837

摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.

公开(公告)号：US20160369355A1

公开(公告)日：2016-12-22

申请号：US15252869

申请日：2016-08-31

申请人： Pacific Edge Limited

发明人： Parry John Guilford ,  Andrew John Holyoake

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57446

摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.

摘要翻译： 肿瘤的早期检测是肿瘤患者（包括胃肿瘤）存活的主要决定因素。 GTM基因家族的成员可能在胃肿瘤组织和其他肿瘤组织中过度表达，因此可用作胃癌和其他类型癌症的标志物。 GTM蛋白可以从癌细胞释放，并且可以在血清和/或其它液体中达到足够高的浓度以允许其检测。 因此，用于GTM检测和定量的方法和检测试剂盒可为胃癌的诊断提供有价值的工具。