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公开(公告)号：US10967068B2
公开(公告)日：2021-04-06
申请号：US15504801
申请日：2015-08-14
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Russell George Dushin , Pavel Strop , Magdalena Grazyna Dorywalska , Ludivine Moine
Abstract: The present invention provides stability-modulated antibody-drug conjugates, stability-modulating linker components used to make these stability-modulated antibody-drug conjugates, therapeutic methods using stability-modulated antibody-drug conjugates, and methods of making stability modulating linkers and stability-modulated antibody-drug conjugates.
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公开(公告)号：US10941216B2
公开(公告)日：2021-03-09
申请号：US15593259
申请日：2017-05-11
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
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公开(公告)号：US20200368349A1
公开(公告)日：2020-11-26
申请号：US16847229
申请日：2020-04-13
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Wei-Hsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
IPC: A61K39/39 , A61K39/395 , A61K45/06 , A61K39/00 , C07K16/28
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US10323086B2
公开(公告)日：2019-06-18
申请号：US15287246
申请日：2016-10-06
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Arnon Rosenthal , David Louis Shelton , Patricia Ann Walicke
IPC: C07K16/22 , A61K39/395 , A61K39/00
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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公开(公告)号：US20190083612A1
公开(公告)日：2019-03-21
申请号：US16188120
申请日：2018-11-12
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： YASMINA NOUBIA ABDICHE , HELEN KIM CHO , WEIHSIEN HO , KAREN UTE JOOSS , ARVAND RAJPAL , SAWSAN YOUSSEF
IPC: A61K39/39 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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Patent Agency Ranking
公开(公告)号：US10138303B2
公开(公告)日：2018-11-27
申请号：US15351275
申请日：2016-11-14
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Weihsien Ho , Jaume Pons , Arvind Rajpal , Pavel Strop
Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US10059772B2
公开(公告)日：2018-08-28
申请号：US15136584
申请日：2016-04-22
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Chia-Yang Lin , Li-Fen Lee , Wenwu Zhai
CPC classification number: C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
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公开(公告)号：US20180140714A1
公开(公告)日：2018-05-24
申请号：US15504801
申请日：2015-08-14
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Russell George DUSHIN , Pavel STROP , Magdalena Grazyna DORYWALSKA , Ludivine MOINE
CPC classification number: A61K47/65 , A61K47/64 , A61K47/6803 , A61K2039/505 , C07K2317/94 , C07K2319/01 , C07K2319/35
Abstract: The present invention provides stability-modulated antibody-drug conjugates, stability-modulating linker components used to make these stability-modulated antibody-drug conjugates, therapeutic methods using stability-modulated antibody-drug conjugates, and methods of making stability modulating linkers and stability-modulated antibody-drug conjugates.
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公开(公告)号：US20170342143A1
公开(公告)日：2017-11-30
申请号：US15622551
申请日：2017-06-14
Applicant: Rinat Neuroscience Corp.
Inventor： Jaume PONS , Arnon ROSENTHAL
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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20.发明申请公开(公告)号：US20170313787A1
公开(公告)日：2017-11-02
申请号：US15593259
申请日：2017-05-11
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Pavel STROP , Magdalena Grazyna DORYWALSKA , Arvind RAJPAL , David SHELTON , Shu-Hui LIU , Jaume PONS , Russell DUSHIN
CPC classification number: C07K17/02 , A61K47/68 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/31 , C07K2317/73
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
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