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公开(公告)号：US20220249657A1
公开(公告)日：2022-08-11
申请号：US17725199
申请日：2022-04-20
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Wei-Hsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
IPC: A61K39/39 , A61K39/395 , A61K45/06 , A61K39/00 , C07K16/28
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US20200368349A1
公开(公告)日：2020-11-26
申请号：US16847229
申请日：2020-04-13
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Wei-Hsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
IPC: A61K39/39 , A61K39/395 , A61K45/06 , A61K39/00 , C07K16/28
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US11338035B2
公开(公告)日：2022-05-24
申请号：US16847229
申请日：2020-04-13
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Wei-Hsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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Patent Agency Ranking
公开(公告)号：US11091544B2
公开(公告)日：2021-08-17
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US20190002559A1
公开(公告)日：2019-01-03
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US10100114B2
公开(公告)日：2018-10-16
申请号：US15160742
申请日：2016-05-20
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US09399074B2
公开(公告)日：2016-07-26
申请号：US14460871
申请日：2014-08-15
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
CPC classification number: C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
Abstract translation: 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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公开(公告)号：US08871908B2
公开(公告)日：2014-10-28
申请号：US13670730
申请日：2012-11-07
Applicant: Rinat Neuroscience Corp.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
CPC classification number: C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
Abstract translation: 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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