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公开(公告)号：US10941216B2
公开(公告)日：2021-03-09
申请号：US15593259
申请日：2017-05-11
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
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公开(公告)号：US20200368349A1
公开(公告)日：2020-11-26
申请号：US16847229
申请日：2020-04-13
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Wei-Hsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
IPC: A61K39/39 , A61K39/395 , A61K45/06 , A61K39/00 , C07K16/28
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US10138303B2
公开(公告)日：2018-11-27
申请号：US15351275
申请日：2016-11-14
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Weihsien Ho , Jaume Pons , Arvind Rajpal , Pavel Strop
Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US20220249657A1
公开(公告)日：2022-08-11
申请号：US17725199
申请日：2022-04-20
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Wei-Hsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
IPC: A61K39/39 , A61K39/395 , A61K45/06 , A61K39/00 , C07K16/28
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US10155037B2
公开(公告)日：2018-12-18
申请号：US14958053
申请日：2015-12-03
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Weihsien Ho , Arvind Rajpal , Sawsan Youssef
IPC: C07K16/28 , A61K39/395 , A61K39/39 , A61K45/06 , A61K39/00
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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Patent Agency Ranking
公开(公告)号：US11338035B2
公开(公告)日：2022-05-24
申请号：US16847229
申请日：2020-04-13
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Wei-Hsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US11091544B2
公开(公告)日：2021-08-17
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US11602525B2
公开(公告)日：2023-03-14
申请号：US15306481
申请日：2015-04-21
Applicant: RINAT NEUROSCIENCE CORP. , PFIZER INC.
Inventor： Pavel Strop , Katherine Anne Delaria , Magdalena Dorywalska , Davide Luciano Foletti , Russell George Dushin , David Louis Shelton , Arvind Rajpal
IPC: A61K31/427 , A61K47/68 , A61K47/65 , C07K16/30 , G01N33/574 , A61K39/00
Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.
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公开(公告)号：US10660953B2
公开(公告)日：2020-05-26
申请号：US16188120
申请日：2018-11-12
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Yasmina Noubia Abdiche , Helen Kim Cho , Weihsien Ho , Karin Ute Jooss , Arvind Rajpal , Sawsan Youssef
IPC: C07K16/28 , A61K39/395 , A61K39/39 , A61K45/06 , A61K39/00
Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US20190002559A1
公开(公告)日：2019-01-03
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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