公开(公告)号：US08067197B2

公开(公告)日：2011-11-29

申请号：US10460672

申请日：2003-06-13

Applicant: Simon L. Goodman ,  Beate Diefenbach ,  Detelv Güssow ,  Raj Mehta ,  Eilish Cullen ,  Alex Brown

Inventor： Simon L. Goodman ,  Beate Diefenbach ,  Detelv Güssow ,  Raj Mehta ,  Eilish Cullen ,  Alex Brown

IPC: C12N15/09 ,  C07H21/04

CPC classification number: C07K14/70557 ,  C12N2799/026

Abstract: The invention relates to a novel purified recombinant αVβ3 adhesion receptor which shows an unimpaired ligand binding activity, and a process for preparing said soluble non-membrane bound receptor in excellent yields by recombinant techniques using a baculovirus-insect cell expression system. The so-synthesized soluble receptor may be used very easily as screening tool for new therapeutic compounds which may inhibit the natural αVβ3 adhesion receptor. Such therapeutic compounds which can be discovered very easily, fast and without health risk by means of the soluble receptors according to the invention may be, for example, RGD peptides or non-peptidic compounds mimicking the natural ligand epitopes. The invention relates, furthermore, to a corresponding process for preparing recombinant full-length αVβ3 adhesion receptor in excellent yields, additionally using detergents to dissolve the membrane bound receptor from the surface of the host cell.

Abstract translation: 本发明涉及一种新型纯化的重组αVb-3粘附受体，其显示出未受损的配体结合活性，以及​​通过使用杆状病毒 - 昆虫细胞表达系统的重组技术以优异的产率制备所述可溶性非膜结合受体的方法。 如此合成的可溶性受体可以非常容易地用作可能抑制天然αV和bgr 3粘附受体的新的治疗化合物的筛选工具。 可以通过本发明的可溶性受体非常容易，快速且没有健康风险发现的这种治疗化合物可以是例如RGD肽或模仿天然配体表位的非肽化合物。 此外，本发明还涉及以优异的产率制备重组全长αV＆bgr 3粘附受体的相应方法，另外使用洗涤剂从宿主细胞表面溶解膜结合受体。

公开(公告)号：US20080287297A1

公开(公告)日：2008-11-20

申请号：US11749012

申请日：2007-05-15

Applicant: Fred Richard Scholer ,  Hsing-Hui Yu ,  Raj Mehta

Inventor： Fred Richard Scholer ,  Hsing-Hui Yu ,  Raj Mehta

IPC: A01N63/00

CPC classification number: A01N63/00 ,  A01N25/08 ,  A01N25/16 ,  A01N25/24 ,  A01N37/34 ,  A01N59/20 ,  A01N2300/00

Abstract: A foaming root destroyer is provided that utilizes a combination of herbicides and bacteria to inhibit and destroy the roots and fine root hairs intruding into underground discharge waste pipe systems. Furthermore, the foaming root destroyer can work over a longer period of time providing an enzymatic process to degrade and eliminate the dead root mass in the sewer line.

Abstract translation: 提供了一种利用除草剂和细菌的组合来抑制和破坏侵入地下排放废物管道系统的根和细根毛的发泡根破坏剂。 此外，发泡根破坏剂可以在更长的时间内工作，提供酶法以降解和消除下水道中的死根质量。

公开(公告)号：US07431378B2

公开(公告)日：2008-10-07

申请号：US11870601

申请日：2007-10-11

Applicant: Xiaoming Chen ,  Omar Faruque ,  Everett Kuo ,  Thierry Guimberteau ,  Raj Mehta ,  James Zimmerman

Inventor： Xiaoming Chen ,  Omar Faruque ,  Everett Kuo ,  Thierry Guimberteau ,  Raj Mehta ,  James Zimmerman

IPC: B62D25/06

CPC classification number: B62D25/06

Abstract: A joint assembly for joining a tubular B-pillar to a tubular roof rail. The joint assembly includes an inner bracket plate and an outer bracket plate that are welded to each other around the roof rail and B-pillar. The outer bracket plate extends across the B-pillar, over the roof rail, and laterally inwardly from the roof rail to provide an attachment surface for a roof support bow.

Abstract translation: 用于将管状B柱连接到管状屋顶导轨的接头组件。 接头组件包括围绕屋顶导轨和B柱彼此焊接的内支架板和外托架板。 外支架板横跨B柱延伸穿过屋顶导轨，并且从屋顶轨道横向向内延伸，以提供用于屋顶支撑弓的附接表面。

公开(公告)号：US20070108803A1

公开(公告)日：2007-05-17

申请号：US11164268

申请日：2005-11-16

Applicant: Xiaoming Chen ,  Omar Faruque ,  Everett Kuo ,  Thierry Guimberteau ,  Raj Mehta ,  James Zimmerman

Inventor： Xiaoming Chen ,  Omar Faruque ,  Everett Kuo ,  Thierry Guimberteau ,  Raj Mehta ,  James Zimmerman

IPC: B62D25/02

CPC classification number: B62D25/06

Abstract: A joint assembly for joining a tubular B-pillar to a tubular roof rail. The joint assembly includes an inner bracket plate and an outer bracket plate that are welded to each other around the roof rail and B-pillar. A flange of the roof rail is received in a slot formed in an upper end of the B-pillar.

Abstract translation: 用于将管状B柱连接到管状屋顶导轨的接头组件。 接头组件包括围绕屋顶导轨和B柱彼此焊接的内支架板和外托架板。 屋顶导轨的凸缘容纳在形成在B柱的上端的槽中。

公开(公告)号：US20060273630A1

公开(公告)日：2006-12-07

申请号：US11276276

申请日：2006-02-22

Applicant: Xiaoming Chen ,  Omar Faruque ,  Thierry Guimberteau ,  Everett Kuo ,  Raj Mehta ,  David Wagner ,  Dean Gericke ,  Daniel Szalay

Inventor： Xiaoming Chen ,  Omar Faruque ,  Thierry Guimberteau ,  Everett Kuo ,  Raj Mehta ,  David Wagner ,  Dean Gericke ,  Daniel Szalay

IPC: B62D25/04

CPC classification number: B62D25/04 ,  B62D25/06 ,  B62D27/02

Abstract: A one-piece B-pillar having a front flange and a rear flange formed on an upper portion of the B-pillar. The front and rear flanges extend forwardly and rearwardly from a trapezoidal section of the B-pillar. An inner concave portion is provided in a lower portion of the B-pillar. The one-piece B-pillar is secured to the outer and upper surfaces of a roof rail and to the outer surface of a rocker to provide side impact strength. The B-pillar is hydroformed in one-piece to provide superior strength for roof crush performance. The tubular portion of the B-pillar is partially collapsed to form a trapezoidal section in the upper portion of the B-pillar.

Abstract translation: 具有形成在B柱的上部的前凸缘和后凸缘的一体式B柱。 前后法兰从B柱的梯形部分向前和向后延伸。 在B柱的下部设置内凹部。 一体式B柱固定在屋顶导轨的外表面和上表面上，并固定到摇臂的外表面以提供侧面冲击强度。 B柱以一体式液压成型，为屋顶压碎性能提供优异的强度。 B柱的管状部分部分地折叠以在B柱的上部形成梯形截面。

公开(公告)号：US06706287B2

公开(公告)日：2004-03-16

申请号：US09855346

申请日：2001-05-15

Applicant: Nataragan Ranganathan ,  Jack Dickstein ,  Raj Mehta

Inventor： Nataragan Ranganathan ,  Jack Dickstein ,  Raj Mehta

IPC: A61K950

CPC classification number: A61K31/736 ,  A23L33/10 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/00 ,  A23Y2300/00 ,  A61K9/5047 ,  A61K9/5052 ,  A61K9/5084 ,  A61K31/702 ,  A61K33/08 ,  A61K35/742 ,  A61K35/745 ,  A61K35/747 ,  A61K36/48 ,  A61K36/483 ,  A61K36/68 ,  A61K2300/00 ,  A23V2250/5062 ,  A23V2250/507

Abstract: Microencapsulated and/or enteric coated compositions containing a mixture of probiotics, prebiotics and ammoniaphilic bacteria with high urease activity with or without sorbents with specific adsorption affinities for uremic toxins such as creatinine, uric acid, phenols, indoles, middle molecular weight molecules and inorganic phosphate and water absorbents are provided. Also provided are methods of alleviating symptoms of uremia in a patient which comprises administering orally to a patient suffering from uremia a microencapsulated and/or enteric-coated composition.

Abstract translation: 微胶囊化和/或肠溶包衣组合物含有益生菌，益生元和具有高尿素酶活性的具有或不具有吸附剂的混合物的混合物，其具有尿素毒素如肌酸酐，尿酸，酚，吲哚，中等分子量分子和无机磷酸盐的特异性吸附亲和力 并提供吸水剂。 还提供了减轻患者尿毒症症状的方法，其包括向患有尿毒症的患者口服施用微囊化和/或肠溶衣组合物。