公开(公告)号：US08835858B2

公开(公告)日：2014-09-16

申请号：US13428840

申请日：2012-03-23

Applicant: Lana Volokh ,  Yaron Hefetz ,  Alexander Ganin ,  Ravindra Manjeshwar

Inventor： Lana Volokh ,  Yaron Hefetz ,  Alexander Ganin ,  Ravindra Manjeshwar

IPC: G01T1/164 ,  A61B6/00

CPC classification number: A61B6/03 ,  A61B6/037 ,  A61B6/483 ,  A61B6/503 ,  A61B6/52 ,  A61B6/5205 ,  A61B6/5258 ,  A61B2576/023 ,  G06T11/005

Abstract: Systems and methods for attenuation compensation in nuclear medicine imaging based on emission data are provided. One method includes acquiring emission data at a plurality of energy windows for a person having administered thereto a radiopharmaceutical comprising at least one radioactive isotope. The method also includes performing a preliminary reconstruction of the acquired emission data to create one or more preliminary images of a peak energy window and a scatter energy window and determining a body outline of the person from at least one of the reconstructed preliminary image of the peak energy window or of the scatter energy window. The method further includes identifying a heart contour and segmenting at least the left lung. The method additionally includes defining an attenuation map based on the body outline and segmented left lung and reconstructing an image of a region of interest of the person using an iterative joint estimation reconstruction.

Abstract translation: 提供了基于发射数据的核医学成像中衰减补偿的系统和方法。 一种方法包括在给予其的人的多个能量窗口上获取包含至少一种放射性同位素的放射性药物的排放数据。 该方法还包括执行所获取的排放数据的初步重建以创建峰值能量窗口和散射能量窗口的一个或多个初步图像，并且从峰值的重建初步图像中的至少一个中确定人物轮廓线 能量窗或散射能窗。 所述方法还包括识别心脏轮廓并分割至少左肺。 该方法还包括基于身体轮廓和分割的左肺定义衰减图，并且使用迭代联合估计重建来重建人的感兴趣区域的图像。

公开(公告)号：US20060261275A1

公开(公告)日：2006-11-23

申请号：US11131149

申请日：2005-05-17

Applicant: Charles Stearns ,  Ravindra Manjeshwar ,  Floribertus Philippus Heukensfeldt Jansen

Inventor： Charles Stearns ,  Ravindra Manjeshwar ,  Floribertus Philippus Heukensfeldt Jansen

IPC: G01T1/164

CPC classification number: G01T1/2985

Abstract: A method and system for reconstructing an image in a time-of-flight (TOF) positron emission tomography (PET) system is provided. The method includes using a reconstructed image to determine predicted timing information. Timing bias data is updated based on received timing information associated with acquired scan data from a PET system and the predicted timing information. The method further includes reconstructing the image, based on the updated timing bias data.

Abstract translation: 提供了一种用于在飞行时间（TOF）正电子发射断层摄影（PET）系统中重建图像的方法和系统。 该方法包括使用重构图像来确定预测的定时信息。 基于与来自PET系统的获取的扫描数据相关联的接收定时信息和预测的定时信息来更新定时偏差数据。 该方法还包括基于更新的定时偏差数据重建图像。

公开(公告)号：US20060138315A1

公开(公告)日：2006-06-29

申请号：US11025233

申请日：2004-12-29

Applicant: John Williams ,  Alexander Ganin ,  Charles Stearns ,  Yiping Shao ,  Floribertus Philippus Martinus Jansen ,  Ravindra Manjeshwar

Inventor： John Williams ,  Alexander Ganin ,  Charles Stearns ,  Yiping Shao ,  Floribertus Philippus Martinus Jansen ,  Ravindra Manjeshwar

IPC: G01T1/164

CPC classification number: G01T1/2985

Abstract: Methods and systems for calibrating a positron emission tomography (PET) system are provided. The method includes determining at least one non-acquisition time period for the PET system. The method further includes automatically acquiring calibration data during the at least one non-acquisition time period.

Abstract translation: 提供了用于校正正电子发射断层摄影（PET）系统的方法和系统。 该方法包括确定PET系统的至少一个非获取时间段。 所述方法还包括在所述至少一个非采集时段期间自动获取校准数据。

公开(公告)号：US08575555B2

公开(公告)日：2013-11-05

申请号：US13077540

申请日：2011-03-31

Applicant: Kristen Ann Wangerin ,  Evren Asma ,  Jorge Uribe ,  Ravindra Manjeshwar

Inventor： Kristen Ann Wangerin ,  Evren Asma ,  Jorge Uribe ,  Ravindra Manjeshwar

IPC: G01T1/166

CPC classification number: G01T1/166 ,  A61B6/037 ,  G01T1/1603 ,  G01T1/1644 ,  G01T1/249

Abstract: A Nuclear Medicine (NM) imaging system and method using multiple types of imaging detectors are provided. One NM imaging system includes a gantry, at least a first imaging detector coupled to the gantry, wherein the first imaging detector is a non-moving detector, and at least a second imaging detector coupled to the gantry, wherein the second imaging detector is a moving detector. The first imaging detector is larger than the second imaging detector and the first and second imaging detectors have different detector configurations. The NM imaging system further includes a controller configured to control the operation of the first and second imaging detectors during an imaging scan of an object to acquire Single Photon Emission Computed Tomography (SPECT) image information such that at least the first imaging detector remains stationary with respect to the gantry during image acquisition.

Abstract translation: 提供了使用多种成像检测器的核医学（NM）成像系统和方法。 一个NM成像系统包括台架，至少第一成像检测器，其耦合到台架，其中第一成像检测器是非移动检测器，以及耦合到台架的至少第二成像检测器，其中第二成像检测器是 移动探测器。 第一成像检测器大于第二成像检测器，并且第一和第二成像检测器具有不同的检测器配置。 NM成像系统还包括控制器，其被配置为在对象的成像扫描期间控制第一和第二成像检测器的操作，以获取单光子发射计算机断层扫描（SPECT）图像信息，使得至少第一成像检测器保持静止， 在图像采集期间对台架的尊重。

公开(公告)号：US20070205368A1

公开(公告)日：2007-09-06

申请号：US11786951

申请日：2007-04-13

Applicant: Floribertus Heukensfeldt Jansen ,  Ravindra Manjeshwar

Inventor： Floribertus Heukensfeldt Jansen ,  Ravindra Manjeshwar

IPC: G01T1/161

CPC classification number: G01T1/2985

Abstract: A method and system for calibrating a time of flight (TOF) positron emission tomography (PET) scanner are provided. The method stores acquired scan data from detector pairs including data and timing information. The method further calculates an intensity distribution of emission sources based on the scan data and defines a timing pivot point based on a median of an intensity histogram. The method determines a timing correction for each detector based on the location of the timing pivot point. The positron emission tomography (PET) system further provides a plurality of detectors, used in performing imaging scans, and a processor. The processor is configured to determine a timing correction for each detector.

Abstract translation: 提供了一种用于校准飞行时间（TOF）正电子发射断层摄影（PET）扫描仪的方法和系统。 该方法存储来自检测器对的获取的扫描数据，包括数据和定时信息。 该方法还基于扫描数据计算发射源的强度分布，并且基于强度直方图的中值来定义定时枢轴点。 该方法基于定时枢轴点的位置确定每个检测器的定时校正。 正电子发射断层摄影（PET）系统还提供用于执行成像扫描的多个检测器和处理器。 处理器被配置为确定每个检测器的定时校正。

公开(公告)号：US20130248719A1

公开(公告)日：2013-09-26

申请号：US13428840

申请日：2012-03-23

Applicant: Lana Volokh ,  Yaron Hefetz ,  Alexander Ganin ,  Ravindra Manjeshwar

Inventor： Lana Volokh ,  Yaron Hefetz ,  Alexander Ganin ,  Ravindra Manjeshwar

IPC: G01T1/164

CPC classification number: A61B6/03 ,  A61B6/037 ,  A61B6/483 ,  A61B6/503 ,  A61B6/52 ,  A61B6/5205 ,  A61B6/5258 ,  A61B2576/023 ,  G06T11/005

Abstract: Systems and methods for attenuation compensation in nuclear medicine imaging based on emission data are provided. One method includes acquiring emission data at a plurality of energy windows for a person having administered thereto a radiopharmaceutical comprising at least one radioactive isotope. The method also includes performing a preliminary reconstruction of the acquired emission data to create one or more preliminary images of a peak energy window and a scatter energy window and determining a body outline of the person from at least one of the reconstructed preliminary image of the peak energy window or of the scatter energy window. The method further includes identifying a heart contour and segmenting at least the left lung. The method additionally includes defining an attenuation map based on the body outline and segmented left lung and reconstructing an image of a region of interest of the person using an iterative joint estimation reconstruction.

Abstract translation: 提供了基于发射数据的核医学成像中衰减补偿的系统和方法。 一种方法包括在给予其的人的多个能量窗口上获取包含至少一种放射性同位素的放射性药物的排放数据。 该方法还包括执行所获取的发射数据的初步重建以创建峰值能量窗口和散射能量窗口的一个或多个初步图像，并且从峰值的重建初步图像中的至少一个中确定人物轮廓线 能量窗或散射能窗。 所述方法还包括识别心脏轮廓并分割至少左肺。 该方法还包括基于身体轮廓和分割的左肺定义衰减图，并且使用迭代联合估计重建来重建人的感兴趣区域的图像。

公开(公告)号：US08010184B2

公开(公告)日：2011-08-30

申请号：US11291830

申请日：2005-11-30

Applicant: Ricardo Avila ,  Floribertus Heukensfeldt Jansen ,  Dinko Gonzalez Trotter ,  James Miller ,  Ravindra Manjeshwar ,  Thomas Sebastian

Inventor： Ricardo Avila ,  Floribertus Heukensfeldt Jansen ,  Dinko Gonzalez Trotter ,  James Miller ,  Ravindra Manjeshwar ,  Thomas Sebastian

IPC: A61B5/055

CPC classification number: G01T1/1611 ,  A61B6/037 ,  A61B34/10 ,  G01R33/4808 ,  G01R33/481 ,  G01R33/4812 ,  G01R33/4814

Abstract: A region of interest is automatically evaluated. The automatic evaluation is based on assessments of one or more characteristics. The one or more characteristics of the region of interest are assessed in a plurality of image data sets acquired by a respective plurality of imaging modalities. In some embodiments, the evaluation is based on assessments of one or more characteristics for each region of interest derived from a combination of structural and functional image data. In one embodiment, the set of structural image data is a set of CT image data and the set of functional image data is a set of PET image data. The one or more lesions may be detected in the structural and/or functional image data by automated routines or by a visual inspection by a clinician or other reviewer.

Abstract translation: 自动评估感兴趣的区域。 自动评估是基于一个或多个特征的评估。 在由相应的多个成像模式获取的多个图像数据集中评估感兴趣区域的一个或多个特征。 在一些实施例中，评估基于从结构和功能图像数据的组合导出的每个感兴趣区域的一个或多个特征的评估。 在一个实施例中，该组结构图像数据是一组CT图像数据，并且功能图像数据集合是一组PET图像数据。 在结构和/或功能图像数据中可以通过自动程序或临床医生或其他审查者的目视检查来检测一个或多个损伤。

公开(公告)号：US20070057189A1

公开(公告)日：2007-03-15

申请号：US11226171

申请日：2005-09-14

Applicant: Floribertus Jansen ,  Ravindra Manjeshwar

Inventor： Floribertus Jansen ,  Ravindra Manjeshwar

IPC: G01T1/161

CPC classification number: G01T1/2985

Abstract: A method and system for calibrating a Time of Flight Positron Emission Tomography (TOF PET) system are provided. The method includes storing acquired scan data from detector pairs. The acquired scan data includes image data and timing information. The method further includes reconstructing images using scan data. The method also includes determining a timing correction for each detector based on intensity distribution histograms of emission sources. The system includes a controller, which is configured to perform the above-mentioned method steps.

Abstract translation: 提供了一种用于校准飞行时间正电子发射断层扫描（TOF PET）系统的方法和系统。 该方法包括从检测器对存储获取的扫描数据。 获取的扫描数据包括图像数据和定时信息。 该方法还包括使用扫描数据重建图像。 该方法还包括基于发射源的强度分布直方图确定每个检测器的定时校正。 该系统包括控制器，其被配置为执行上述方法步骤。

公开(公告)号：US20060081784A1

公开(公告)日：2006-04-20

申请号：US10969716

申请日：2004-10-20

Applicant: Steven Ross ,  Charles Stearns ,  Ravindra Manjeshwar

Inventor： Steven Ross ,  Charles Stearns ,  Ravindra Manjeshwar

IPC: G01T1/164

CPC classification number: G06T11/006 ,  G06T2211/424

Abstract: Methods and systems for image overlap correction are provided. The method includes acquiring the emission projection data from a plurality of scan frames that extend across at least a portion of a length of an object being imaged wherein elements of the object lie between a region of overlap between two successive frames. The method further includes iteratively reconstructing a 3D image volume from multi-frame emission projection data by updating an estimate of 3D image volume using emission projection data from the plurality of frames within an iterative reconstruction loop.

Abstract translation: 提供了图像重叠校正的方法和系统。 该方法包括从多个扫描帧中获取发射投影数据，所述多个扫描帧延伸穿过被成像物体的长度的至少一部分，其中物体的元件位于两个连续帧之间的重叠区域之间。 该方法还包括通过使用来自迭代重建循环内的多个帧的发射投影数据更新3D图像体积的估计来从多帧发射投影数据中迭代重建3D图像体积。