公开(公告)号：US20070057189A1

公开(公告)日：2007-03-15

申请号：US11226171

申请日：2005-09-14

Applicant: Floribertus Jansen ,  Ravindra Manjeshwar

Inventor： Floribertus Jansen ,  Ravindra Manjeshwar

IPC: G01T1/161

CPC classification number: G01T1/2985

Abstract: A method and system for calibrating a Time of Flight Positron Emission Tomography (TOF PET) system are provided. The method includes storing acquired scan data from detector pairs. The acquired scan data includes image data and timing information. The method further includes reconstructing images using scan data. The method also includes determining a timing correction for each detector based on intensity distribution histograms of emission sources. The system includes a controller, which is configured to perform the above-mentioned method steps.

Abstract translation: 提供了一种用于校准飞行时间正电子发射断层扫描（TOF PET）系统的方法和系统。 该方法包括从检测器对存储获取的扫描数据。 获取的扫描数据包括图像数据和定时信息。 该方法还包括使用扫描数据重建图像。 该方法还包括基于发射源的强度分布直方图确定每个检测器的定时校正。 该系统包括控制器，其被配置为执行上述方法步骤。

公开(公告)号：US20070167697A1

公开(公告)日：2007-07-19

申请号：US11291830

申请日：2005-11-30

Applicant: Ricardo Avila ,  Floribertus Jansen ,  Dinko Trotter ,  James Miller ,  Ravindra Manjeshwar ,  Thomas Sebastian

Inventor： Ricardo Avila ,  Floribertus Jansen ,  Dinko Trotter ,  James Miller ,  Ravindra Manjeshwar ,  Thomas Sebastian

IPC: A61B5/05

CPC classification number: G01T1/1611 ,  A61B6/037 ,  A61B34/10 ,  G01R33/4808 ,  G01R33/481 ,  G01R33/4812 ,  G01R33/4814

Abstract: A malignancy probability is automatically calculated for one or more lesions. The malignancy probability is based on assessments of one or more malignancy characteristics for each lesion derived from two or more structural and/or functional image data sets. Likewise, in some embodiments, the malignancy probability is based on assessments of one or more malignancy characteristics for each lesion derived from a combination of structural and functional image data. In one embodiment, the set of structural image data is a set of CT image data and the set of functional image data is a set of PET image data. The one or more lesions may be detected in the structural and/or functional image data by automated routines or by a visual inspection by a clinician or other reviewer.

Abstract translation: 自动计算一个或多个病变的恶性概率。 恶性概率基于从两个或多个结构和/或功能图像数据集导出的每个病变的一个或多个恶性特征的评估。 类似地，在一些实施例中，恶性概率基于从结构和功能图像数据的组合导出的每个损伤的一个或多个恶性特征的评估。 在一个实施例中，该组结构图像数据是一组CT图像数据，并且功能图像数据集合是一组PET图像数据。 在结构和/或功能图像数据中可以通过自动程序或临床医生或其他审查者的目视检查来检测一个或多个损伤。

公开(公告)号：US20050107694A1

公开(公告)日：2005-05-19

申请号：US10714734

申请日：2003-11-17

Applicant: Floribertus Jansen ,  Peter Lorraine ,  Stephen Lomnes ,  Pavel Fomitchov

Inventor： Floribertus Jansen ,  Peter Lorraine ,  Stephen Lomnes ,  Pavel Fomitchov

IPC: A61B5/00 ,  G01N21/17 ,  G01N21/47 ,  A61B6/00 ,  A61B8/00

CPC classification number: G01N21/6456 ,  A61B5/0051 ,  A61B5/0091 ,  A61B5/4312 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0034 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  G01N21/1717 ,  G01N21/4795 ,  G01N2021/1729 ,  G01N2021/6439

Abstract: A method and system for localization of fluorescence in a scattering medium such as a biological tissue are provided. In comparison to other optical imaging techniques, this disclosure provides for improved spatial resolution, decreased computational time for reconstructions, and allows anatomical and functional imaging simultaneously. The method including the steps of illuminating the scattering medium with an excitation light to excite the fluorescence; modulating a portion of the emitted light from the fluorescence within the scattering medium using an ultrasonically induced variation of material properties of the scattering medium such as the refractive index; detecting the modulated optical signal at a surface of the scattering medium; and reconstructing a spatial distribution of the fluorescence in the scattering medium from the detected signal.

Abstract translation: 提供了用于在诸如生物组织的散射介质中定位荧光的方法和系统。 与其他光学成像技术相比，本公开提供了改进的空间分辨率，减少重建的计算时间，并且同时允许解剖和功能成像。 该方法包括以激发光照射散射介质以激发荧光的步骤; 使用散射介质的材料性质如折射率的超声波诱导的变化来调制来自散射介质内的荧光的一部分发射光; 检测所述散射介质的表面处的调制光信号; 以及从所检测的信号重构散射介质中的荧光的空间分布。

公开(公告)号：US20050255044A1

公开(公告)日：2005-11-17

申请号：US10846062

申请日：2004-05-14

Applicant: Stephen Lomnes ,  Egidijus Uzgiris ,  Floribertus Jansen ,  Pavel Fomitchov ,  Omayra De Jesus

Inventor： Stephen Lomnes ,  Egidijus Uzgiris ,  Floribertus Jansen ,  Pavel Fomitchov ,  Omayra De Jesus

IPC: A61B10/00 ,  A61B8/00 ,  A61K41/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/00

CPC classification number: A61B5/0059 ,  A61K41/0028 ,  A61K49/0089

Abstract: In accordance with embodiments of the present technique, a combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality. The first and the second imaging devices are both adapted to interact with a contrast agent adapted to be received in a subject. The contrast agent includes an deformable particle that has a geometry that varies in response to an emission from the first imaging device. The deformable particle also includes a fluorescent component adapted to emit electromagnetic radiation that is detectable by the second imaging device and a quenching component separated from the fluorescent component at a distance based on the geometry and that which is adapted to absorb a portion of the electromagnetic radiation from the fluorescent component.

Abstract translation: 根据本技术的实施例，组合模态成像系统包括第一模态的第一成像装置和与第一模态不同的第二模态的第二成像装置。 第一和第二成像装置都适于与适于被接收在受试者中的造影剂相互作用。 造影剂包括可变形颗粒，其具有响应于来自第一成像装置的发射而变化的几何形状。 可变形颗粒还包括适于发射可被第二成像装置检测的电磁辐射的荧光组件，以及基于该几何形状在一定距离处从荧光组件分离的淬火组分，以及适于吸收电磁辐射的一部分 从荧光成分。