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22 条记录 (耗时 0.017 秒)

    Method of identifying modulators of presenilin
    12.
    发明申请
    Method of identifying modulators of presenilin 审中-公开
    识别早老素调节剂的方法

    公开(公告)号：US20050101766A1

    公开(公告)日：2005-05-12

    申请号：US10221291

    申请日：2001-03-09

    申请人： Walter Blackstock ,  Richard Hale ,  Adele Rowley

    发明人： Walter Blackstock ,  Richard Hale ,  Adele Rowley

    IPC分类号： G01N33/68 ,  C07K14/705

    CPC分类号： G01N33/6896 ,  G01N2500/00

    摘要： A method of identifying a modulator of presenilin function, the method comprising: (i) providing (a) a polypeptide capable of binding a presenilin, which polypeptide comprises the amino acid sequence of SEQ ID NO: 1 or a functional variant thereof, or a fragment of either thereof which is capable of binding to presenilin; (b) a presenilin or a variant thereof or a fragment of either thereof capable of binding to a polypeptide which comprises the amino acid sequence of SEQ ID NO: 1; (c) a test substance under conditions that would permit binding of a polypeptide (a) to a presenilin (b) in the absence of the test substance; (ii) monitoring presenilin mediated activity; and (iii) determining thereby whether the test substance is a modulator of presenilin activity, a modulator identified by a method of the invention and use of a modulator identified by a method of the invention in the treatment of Alzheimer's disease.

    摘要翻译： 一种识别早老蛋白功能调节剂的方法，所述方法包括：（i）提供（a）能够结合早老蛋白的多肽，所述多肽包含SEQ ID NO：1的氨基酸序列或其功能变体，或 其能够结合早熟蛋白的片段; （b）能够与包含SEQ ID NO：1的氨基酸序列的多肽结合的早老素或其变体或其一个片段; （c）在不存在测试物质的条件下允许多肽（a）与早老蛋白（b）结合的条件下的测试物质; （ii）监测早老素介导的活性; 和（iii）由此确定测试物质是否是早老蛋白活性的调节剂，通过本发明的方法鉴定的调节剂以及通过本发明的方法鉴定的调节剂在治疗阿尔茨海默氏病中的用途。

    Process and heuristic statistic for prospect selection through data mining
    14.
    发明授权
    Process and heuristic statistic for prospect selection through data mining 失效
    通过数据挖掘进行前景选择的过程和启发式统计

    公开(公告)号：US08036931B2

    公开(公告)日：2011-10-11

    申请号：US10742099

    申请日：2003-12-19

    申请人： Curtis Richard Hale ,  John Baxter Rollins

    发明人： Curtis Richard Hale ,  John Baxter Rollins

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/02 ,  G06Q30/0207 ,  G06Q30/0244 ,  G06Q30/0251

    摘要： An initial set of prospects in a customer database is identified, by data mining, as initially identified prospects based on predetermined selection criteria. The number of initially identified prospects is compared to a target number of prospects. When the number of initially identified prospects matches the target number of prospects, the initially identified prospects are utilized as the final selection of prospects. When the number of initially identified prospects mismatches the target number of prospects, the final selection of prospects is determined by performing a culling process or an augmenting process to reduce or increase, respectively, the initial set of prospects using a heuristic measure H, until the number of prospects in the initial set of prospects matches the target number of prospects.

    摘要翻译： 通过数据挖掘，根据预先确定的选择标准，将最初确定的前景识别出客户数据库中的初始集合。 将最初确定的前景数量与目标数量的前景进行比较。 当初始确定的前景数量与目标数量匹配时，初步确定的前景被用作最终的前景选择。 当初始确定的前景数量与目标数量的前景不匹配时，前景的最终选择是通过执行剔除过程或增加过程来确定的，以分别使用启发式测量H来减少或增加初始集合的前景，直到 初步前景数量与目标数量相符。

    Process and heuristic statistic for prospect selection through data mining
    15.
    发明授权
    Process and heuristic statistic for prospect selection through data mining 失效
    通过数据挖掘进行前景选择的过程和启发式统计

    公开(公告)号：US07725415B2

    公开(公告)日：2010-05-25

    申请号：US12139649

    申请日：2008-06-16

    申请人： Curtis Richard Hale ,  John Baxter Rollins

    发明人： Curtis Richard Hale ,  John Baxter Rollins

    IPC分类号： G06F17/00 ,  G06F19/00

    CPC分类号： G06Q30/02 ,  G06Q30/0207 ,  G06Q30/0244 ,  G06Q30/0251

    摘要： Method, system, and article of manufacture for selecting prospects for a product promotion though data mining. An initial set of prospects in a customer database is identified, by data mining, as initially identified prospects based on predetermined selection criteria. The number of initially identified prospects is compared to a target number of prospects. When the number of initially identified prospects matches the target number of prospects, the initially identified prospects are utilized as the final selection of prospects. When the number of initially identified prospects mismatches the target number of prospects, the final selection of prospects is determined by performing a culling process or an augmenting process to reduce or increase, respectively, the initial set of prospects using a heuristic measure H, until the number of prospects in the initial set of prospects matches the target number of prospects.

    摘要翻译： 通过数据挖掘选择产品推广前景的方法，系统和制造。 通过数据挖掘，根据预先确定的选择标准，将最初确定的前景识别出客户数据库中的初始集合。 将最初确定的前景数量与目标数量的前景进行比较。 当初始确定的前景数量与目标数量匹配时，初步确定的前景被用作最终的前景选择。 当初始确定的前景数量与目标数量的前景不一致时，通过执行剔除过程或扩充过程来确定前景的最终选择，以分别使用启发式测量H来减少或增加初始集合的前景，直到 初步前景数量与目标数量相符。

    Components of the presenilin-complex
    17.
    发明申请
    Components of the presenilin-complex 审中-公开
    早老素复合物的组分

    公开(公告)号：US20050288212A1

    公开(公告)日：2005-12-29

    申请号：US10519238

    申请日：2003-06-25

    申请人： Richard Hale ,  Adele Rowley

    发明人： Richard Hale ,  Adele Rowley

    IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/47 ,  C07K19/00 ,  G01N33/68 ,  C07K14/705 ,  C07K16/28 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention is based on a novel direct interaction between a Presenilin and a novel protein identified herein and named Sambiasin-1, a homolog thereof named Sambiasin-2, as well as a protein complex further comprising a Nicastrin. Also comprised are uses of said components and complexes, as well as methods for use of the protein and the complex, inter alia, screening, diagnosis and therapy, as well as methods of preparing the complexes.

    摘要翻译： 本发明是基于本文鉴定的早老素和新蛋白质之间的新型直接相互作用，并命名为Sambiasin-1，其名称为Sambiasin-2的同系物，以及进一步包含Nicastrin的蛋白质复合物。 还包括所述组分和复合物的用途，以及蛋白质和复合物的使用方法，特别是筛选，诊断和治疗以及制备复合物的方法。

    Adjustable chairs and beds
    18.
    发明申请
    Adjustable chairs and beds 失效
    可调椅子和床

    公开(公告)号：US20050151406A1

    公开(公告)日：2005-07-14

    申请号：US11071216

    申请日：2005-03-04

    申请人： Richard Hale

    发明人： Richard Hale

    IPC分类号： A47C1/02 ,  A47C3/20

    CPC分类号： A61G5/14 ,  Y10S297/10

    摘要： An adjustable chair (1) includes a chassis (2) onto which the chair is moveably mounted with respect thereto about a common plane normal to the major plane of the chassis, a pair of side walls (8) extending from the chassis and adapted to, in use, prevent accidental access to the space between the chassis and the chair from respective sides thereof, wherein at least one tambour (9,10) is provided between the front and/or the rear of the chair relative to said side, the or each tambour therefore providing a rigid but moveable barrier to accidental entry into the space between the chair and the chassis.

    摘要翻译： 一个可调式椅子（1）包括一个底盘（2），椅子相对于其可移动地围绕与底盘的主平面垂直的公共平面可移动地安装在该底盘上;一对侧壁（8），其从底盘延伸并适于 在使用中，防止从其相应侧面意外地进入底盘和椅子之间的空间，其中在椅子的前部和/或后部之间相对于所述侧面设置至少一个手鼓（9,10）， 或者每个嘟嘟声因此提供刚性但可移动的屏障以意外进入椅子和底盘之间的空间。

    Lamination equipment
    19.
    发明授权
    Lamination equipment 失效
    层压设备

    公开(公告)号：US5738754A

    公开(公告)日：1998-04-14

    申请号：US636418

    申请日：1996-04-23

    申请人： Lawrence Alexander Hill ,  Leon Richard Hale ,  Robert Seth Sherwin

    发明人： Lawrence Alexander Hill ,  Leon Richard Hale ,  Robert Seth Sherwin

    IPC分类号： B32B37/15 ,  B32B31/04

    CPC分类号： B32B37/0053 ,  B32B37/153 ,  Y10T156/1741

    摘要： Equipment for laminating webs has a pressure sensitive roller formed of a polymeric material layer resistant to wetting by molten polyethylene resin. A web transport surface for conveying the web during lamination is formed by the pressure sensitive layer and abutting solid, relatively thick polymeric material layers, preferably Teflon, which is secured against movement about the core and urged into substantial uniformity with the pressure sensitive layer by a locking ring assembly.

    摘要翻译： 用于层压纤维网的设备具有由耐熔融聚乙烯树脂润湿的聚合材料层形成的压敏辊。 用于在层压期间输送幅材的幅材输送表面由压敏层形成，并抵靠固体，相对较厚的聚合物材料层，优选聚四氟乙烯，聚四氟乙烯防止围绕芯移动并被压力与压敏层基本一致 锁环组件。