公开(公告)号：US20050101766A1

公开(公告)日：2005-05-12

申请号：US10221291

申请日：2001-03-09

申请人： Walter Blackstock ,  Richard Hale ,  Adele Rowley

发明人： Walter Blackstock ,  Richard Hale ,  Adele Rowley

IPC分类号： G01N33/68 ,  C07K14/705

CPC分类号： G01N33/6896 ,  G01N2500/00

摘要： A method of identifying a modulator of presenilin function, the method comprising: (i) providing (a) a polypeptide capable of binding a presenilin, which polypeptide comprises the amino acid sequence of SEQ ID NO: 1 or a functional variant thereof, or a fragment of either thereof which is capable of binding to presenilin; (b) a presenilin or a variant thereof or a fragment of either thereof capable of binding to a polypeptide which comprises the amino acid sequence of SEQ ID NO: 1; (c) a test substance under conditions that would permit binding of a polypeptide (a) to a presenilin (b) in the absence of the test substance; (ii) monitoring presenilin mediated activity; and (iii) determining thereby whether the test substance is a modulator of presenilin activity, a modulator identified by a method of the invention and use of a modulator identified by a method of the invention in the treatment of Alzheimer's disease.

摘要翻译： 一种识别早老蛋白功能调节剂的方法，所述方法包括：（i）提供（a）能够结合早老蛋白的多肽，所述多肽包含SEQ ID NO：1的氨基酸序列或其功能变体，或 其能够结合早熟蛋白的片段; （b）能够与包含SEQ ID NO：1的氨基酸序列的多肽结合的早老素或其变体或其一个片段; （c）在不存在测试物质的条件下允许多肽（a）与早老蛋白（b）结合的条件下的测试物质; （ii）监测早老素介导的活性; 和（iii）由此确定测试物质是否是早老蛋白活性的调节剂，通过本发明的方法鉴定的调节剂以及通过本发明的方法鉴定的调节剂在治疗阿尔茨海默氏病中的用途。

公开(公告)号：US20050288212A1

公开(公告)日：2005-12-29

申请号：US10519238

申请日：2003-06-25

申请人： Richard Hale ,  Adele Rowley

发明人： Richard Hale ,  Adele Rowley

IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/47 ,  C07K19/00 ,  G01N33/68 ,  C07K14/705 ,  C07K16/28 ,  G01N33/53 ,  G01N33/567

CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention is based on a novel direct interaction between a Presenilin and a novel protein identified herein and named Sambiasin-1, a homolog thereof named Sambiasin-2, as well as a protein complex further comprising a Nicastrin. Also comprised are uses of said components and complexes, as well as methods for use of the protein and the complex, inter alia, screening, diagnosis and therapy, as well as methods of preparing the complexes.

摘要翻译： 本发明是基于本文鉴定的早老素和新蛋白质之间的新型直接相互作用，并命名为Sambiasin-1，其名称为Sambiasin-2的同系物，以及进一步包含Nicastrin的蛋白质复合物。 还包括所述组分和复合物的用途，以及蛋白质和复合物的使用方法，特别是筛选，诊断和治疗以及制备复合物的方法。

公开(公告)号：US5150332A

公开(公告)日：1992-09-22

申请号：US746640

申请日：1991-08-19

申请人： Richard Bale ,  Richard Hale

发明人： Richard Bale ,  Richard Hale

IPC分类号： G01V1/34

CPC分类号： G01V1/34

摘要： A method of assigning seismic traces obtained by means of one or more seismic sources (1) and receivers (2) wherein, a plane containing each source (1) and receivers (2) is divided into a regular array of regions (12-18), for example a rectangular array referred to cartesian coordinates (X-Y). The regions cover at least a middle portion of a line (11) joining each source (1) to each receiver (2). Diagonals (19-25) intersect the line (11) at respective intersection points and offspring traces are allocated to these points.

摘要翻译： 一种分配通过一个或多个地震源（1）和接收器（2）获得的地震迹线的方法，其中，包含每个源（1）和接收器（2）的平面被划分为规则的阵列阵列（12-18 ），例如，涉及笛卡尔坐标（XY）的矩形阵列。 这些区域覆盖将每个源（1）连接到每个接收器（2）的线路（11）的至少中间部分。 对角线（19-25）在相应交点处与线（11）相交，并将后代轨迹分配给这些点。

公开(公告)号：US20050151406A1

公开(公告)日：2005-07-14

申请号：US11071216

申请日：2005-03-04

申请人： Richard Hale

发明人： Richard Hale

IPC分类号： A47C1/02 ,  A47C3/20

CPC分类号： A61G5/14 ,  Y10S297/10

摘要： An adjustable chair (1) includes a chassis (2) onto which the chair is moveably mounted with respect thereto about a common plane normal to the major plane of the chassis, a pair of side walls (8) extending from the chassis and adapted to, in use, prevent accidental access to the space between the chassis and the chair from respective sides thereof, wherein at least one tambour (9,10) is provided between the front and/or the rear of the chair relative to said side, the or each tambour therefore providing a rigid but moveable barrier to accidental entry into the space between the chair and the chassis.

摘要翻译： 一个可调式椅子（1）包括一个底盘（2），椅子相对于其可移动地围绕与底盘的主平面垂直的公共平面可移动地安装在该底盘上;一对侧壁（8），其从底盘延伸并适于 在使用中，防止从其相应侧面意外地进入底盘和椅子之间的空间，其中在椅子的前部和/或后部之间相对于所述侧面设置至少一个手鼓（9,10）， 或者每个嘟嘟声因此提供刚性但可移动的屏障以意外进入椅子和底盘之间的空间。