公开(公告)号：US20110199078A1

公开(公告)日：2011-08-18

申请号：US12704775

申请日：2010-02-12

Applicant: Chinwuba Ezekwe ,  Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi ,  Martin Krämer

Inventor： Chinwuba Ezekwe ,  Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi ,  Martin Krämer

IPC: G01R33/09 ,  G01R19/145 ,  G06F19/00

CPC classification number: G01R33/093 ,  B82Y25/00

Abstract: A magnetic field measuring system is disclosed. The magnetic field measuring system includes a substrate, a conductive well formed in the substrate, the well having a first side with a first length, a first contact electrically coupled to the conductive well at a first location of the first side, a second contact electrically coupled to the conductive well at a second location of the first side, wherein the distance between the first location and the second location is less than the first length, a stimulus circuit coupled to the first contact and the second contact, and a sensor for identifying a property indicative of the length of a current path from the first location to the second location through the conductive well.

Abstract translation: 公开了一种磁场测量系统。 所述磁场测量系统包括衬底，在所述衬底中形成的导电阱，所述阱具有第一长度的第一侧，在所述第一侧的第一位置处电耦合到所述导电阱的第一接触， 在所述第一侧的第二位置处耦合到所述导电阱，其中所述第一位置和所述第二位置之间的距离小于所述第一长度，耦合到所述第一接触和所述第二接触的刺激电路，以及用于识别 指示通过导电井从第一位置到第二位置的电流路径的长度的特性。

公开(公告)号：US09188585B2

公开(公告)日：2015-11-17

申请号：US12779687

申请日：2010-05-13

Applicant: Sam Kavusi ,  Yi Wei Chen ,  Michael Chen ,  Christoph Lang

Inventor： Sam Kavusi ,  Yi Wei Chen ,  Michael Chen ,  Christoph Lang

IPC: G01N1/00 ,  G01N33/543

CPC classification number: G01N33/54306 ,  G01N33/54366 ,  G01N33/54393 ,  Y10T436/25

Abstract: A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a first activatable stimulant at the test site, providing an actuator configured to activate the first activatable stimulant at the test site, controlling the actuator to activate the first activatable stimulant, and modifying the local chemical environment at the test site with the first activated stimulant.

Abstract translation: 在一个实施方案中间接改变测试部位环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供第一可激活的刺激剂，提供构造成在测试部位激活第一可活化刺激物的致动器 控制致动器来激活第一可激活的兴奋剂，以及用第一个激活的兴奋剂改变测试部位的局部化学环境。

公开(公告)号：US09075041B2

公开(公告)日：2015-07-07

申请号：US13543300

申请日：2012-07-06

Applicant: Sam Kavusi ,  Rajan Gangadharan ,  Christopher Johnson ,  Aldrich N. K. Lau ,  Piyush Verma

Inventor： Sam Kavusi ,  Rajan Gangadharan ,  Christopher Johnson ,  Aldrich N. K. Lau ,  Piyush Verma

IPC: G01N33/50 ,  G01N27/327 ,  G01N33/53

CPC classification number: G01N33/50 ,  G01N27/3275 ,  G01N33/5306

Abstract: Methods of modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological sample in a biosensor having a multisite array of test sites. In particular, the methods modulate the pH or ionic concentration gradient near the electrodes in such biosensor. The methods of modulating the binding interactions provide a biosensor and analytic methods for more accurately measuring an analyte of interest in a biological sample.

Abstract translation: 在生物传感器中调节生物样品中生物分子探针或检测剂与目的分析物之间的结合相互作用的方法，该生物传感器具有多个测试位点阵列。 特别地，该方法调节这种生物传感器中电极附近的pH或离子浓度梯度。 调节结合相互作用的方法提供了生物传感器和分析方法，用于更精确地测量生物样品中感兴趣的分析物。

公开(公告)号：US20140274760A1

公开(公告)日：2014-09-18

申请号：US13834126

申请日：2013-03-15

Applicant: Nadezda FOMINA ,  Christopher JOHNSON ,  Sam KAVUSI ,  Habib AHMAD

Inventor： Nadezda FOMINA ,  Christopher JOHNSON ,  Sam KAVUSI ,  Habib AHMAD

IPC: G01N33/543

CPC classification number: G01N33/5438 ,  G01N27/3272

Abstract: Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.

Abstract translation: 用于生物传感器的装置，其包括测试位点的多位阵列，所述装置可用于通过调节电极附近的pH或离子梯度来调节生物学上的（生物分子）探针或检测剂和目标分析物之间的结合相互作用 在这样的生物传感器。 该装置提供了更准确，可靠的生物传感器，其结果更加可重现。 还提供了用于更精确地测量生物样品中感兴趣的分析物的分析方法。

公开(公告)号：US20140274754A1

公开(公告)日：2014-09-18

申请号：US13800328

申请日：2013-03-13

Applicant: Christopher JOHNSON ,  Sam KAVUSI ,  Habib AHMAD ,  Christoph LANG

Inventor： Christopher JOHNSON ,  Sam KAVUSI ,  Habib AHMAD ,  Christoph LANG

IPC: G01N27/327

CPC classification number: G01N27/3276 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/089 ,  B01L2400/0406 ,  G01N33/5438 ,  G01N33/558

Abstract: Lateral flow assay devices for determining the concentration of a biomolecular analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow assay devices.

Abstract translation: 用于确定样品中生物分子分析物的浓度的侧流测定装置和使用这种侧流测定装置测量样品中的分析物浓度的方法。

公开(公告)号：US08476935B2

公开(公告)日：2013-07-02

申请号：US12497216

申请日：2009-07-02

Applicant: Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi

Inventor： Robert Wolf ,  Christoph Lang ,  Xinyu Xing ,  Sam Kavusi

IPC: H03K5/22

CPC classification number: H03F1/38 ,  H03K5/08 ,  H03K5/2481

Abstract: A method and circuit for attenuating positive feedback in a comparator in one embodiment includes an amplifier configured to compare a first input signal with a second input signal and to provide an output based upon the comparison, a non-linear function with a first input operably connected to an output of the amplifier, and a feedback loop operably connected to the output of the non-linear function and to a second input of the non-linear function, the feedback loop including a feedback limiting circuit configured to attenuate a feedback signal to the second input of the non-linear function.

Abstract translation: 在一个实施例中用于衰减比较器中的正反馈的方法和电路包括：放大器，被配置为将第一输入信号与第二输入信号进行比较，并且基于比较提供输出，非线性函数与第一输入可操作地连接 耦合到放大器的输出端，以及可操作地连接到非线性功能的输出端和非线性功能的第二输入端的反馈回路，反馈回路包括反馈限制电路，该反馈限制电路被配置为将反馈信号衰减到 第二输入的非线性函数。

公开(公告)号：US20120079897A1

公开(公告)日：2012-04-05

申请号：US12895361

申请日：2010-09-30

Applicant: Sam Kavusi ,  Christoph Lang

Inventor： Sam Kavusi ,  Christoph Lang

IPC: G01N33/00

CPC classification number: G01N33/48707

Abstract: A system and method of providing a confidence test in one embodiment includes determining a first quality metric based upon a first and a second test environment wherein the second test environment is different from the first test environment, exposing a sample to a plurality of test sites, establishing the first test environment at a first of the plurality of test sites, establishing the second test environment at a second test site, obtaining a first detection signal associated with the first of the plurality of test sites exposed to the sample and at the first test environment, obtaining a second detection signal associated with the second of the plurality of test sites exposed to the sample and at the second test environment, determining a second quality metric based upon the first detection signal and the second detection signal, and comparing the second quality metric with the first quality metric.

Abstract translation: 在一个实施例中提供置信度测试的系统和方法包括基于第一和第二测试环境确定第一质量度量，其中第二测试环境与第一测试环境不同，将样本暴露于多个测试位置， 在所述多个测试点中的第一测试场所建立所述第一测试环境，在第二测试位置建立所述第二测试环境，获得与暴露于所述样品的所述多个测试点中的第一测试位点相关联的第一检测信号，以及在所述第一测试 获得与所述多个测试站点中的第二个暴露于所述样本并在所述第二测试环境相关联的第二检测信号，基于所述第一检测信号和所述第二检测信号确定第二质量度量，以及将所述第二质量 度量与第一个质量度量。

公开(公告)号：US20110091870A1

公开(公告)日：2011-04-21

申请号：US12580113

申请日：2009-10-15

Applicant: Christoph Lang ,  Sam Kavusi ,  Daniel Roser ,  AmirAli Haj Hossein Talasaz

Inventor： Christoph Lang ,  Sam Kavusi ,  Daniel Roser ,  AmirAli Haj Hossein Talasaz

IPC: C12Q1/68 ,  G01N33/566

CPC classification number: G01N33/54393 ,  G01N29/32 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54366

Abstract: A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.

Abstract translation: 在一个实施方案中检测生物标志物的方法包括鉴定样品中的生物分子类型的数量，将样品暴露于多个测试位点，其中多个测试位点中的测试位点的数目等于或大于所鉴定的 生物分子类型的数量，为多个测试点中的每一个建立相应的测试环境，其中，所述多个测试位置中的每一个的测试环境与所述多个测试位置中的每一个的每个测试位置中的每一个的测试环境不同 获得与所述多个测试点中的每一个相关联的检测信号，以及基于所获得的检测信号来确定所述生物分子类型之一的浓度。

公开(公告)号：US20120197534A1

公开(公告)日：2012-08-02

申请号：US13017391

申请日：2011-01-31

Applicant: Sam Kavusi ,  Christoph Lang

Inventor： Sam Kavusi ,  Christoph Lang

IPC: G06F19/00

CPC classification number: G06F19/28 ,  G16H10/40 ,  G16H15/00 ,  G16H50/30

Abstract: A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.

Abstract translation: 在一个实施方案中的生物标志物监测方法和系统包括通信网络，配置为与通信网络形成通信链路的便携式健康设备，便携式健康设备包括被配置成检测生物样品中的至少一种生物标志物的检测器， 存储器，存储在第一存储器中的多个程序指令以及可操作地连接到第一存储器并且被配置为执行程序指令以基于生物样本中的至少一个生物标志物的检测来生成健康数据的处理电路，以及 远程用户界面可操作地连接到通信网络并且被配置为呈现健康数据。

公开(公告)号：US08093891B2

公开(公告)日：2012-01-10

申请号：US12396204

申请日：2009-03-02

Applicant: Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi

Inventor： Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi

IPC: G01R33/06

CPC classification number: H01L43/065 ,  G01R33/07 ,  G01R33/077

Abstract: A complimentary metal oxide semiconductor (CMOS) sensor system in one embodiment includes a doped well extending along a first axis of a doped substrate, a first electrical contact positioned within the doped well, a second electrical contact positioned within the doped well and spaced apart from the first electrical contact along the first axis, a third electrical contact positioned within the doped well and located between the first electrical contact and the second electrical contact along the first axis, and a fourth electrical contact electrically coupled to the doped well at a location of the doped well below the third electrical contact.

Abstract translation: 在一个实施例中，互补的金属氧化物半导体（CMOS）传感器系统包括沿着掺杂衬底的第一轴延伸的掺杂阱，位于掺杂阱内的第一电触点，位于掺杂阱内并与之隔开的第二电触点 沿着第一轴线的第一电触头，位于掺杂阱内并位于第一电触点和第二电触点之间的第三电触头沿着第一轴线，以及第四电触点，其电耦合到位于 掺杂深度低于第三电接触。