公开(公告)号：US08717015B2

公开(公告)日：2014-05-06

申请号：US12704775

申请日：2010-02-12

申请人： Chinwuba Ezekwe ,  Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi ,  Martin Kramer

发明人： Chinwuba Ezekwe ,  Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi ,  Martin Kramer

IPC分类号： G01R33/06

CPC分类号： G01R33/093 ,  B82Y25/00

摘要： A magnetic field measuring system is disclosed. The magnetic field measuring system includes a substrate, a conductive well formed in the substrate, the well having a first side with a first length, a first contact electrically coupled to the conductive well at a first location of the first side, a second contact electrically coupled to the conductive well at a second location of the first side, wherein the distance between the first location and the second location is less than the first length, a stimulus circuit coupled to the first contact and the second contact, and a sensor for identifying a property indicative of the length of a current path from the first location to the second location through the conductive well.

摘要翻译： 公开了一种磁场测量系统。 所述磁场测量系统包括衬底，在所述衬底中形成的导电阱，所述阱具有第一长度的第一侧，在所述第一侧的第一位置处电耦合到所述导电阱的第一接触， 在所述第一侧的第二位置处耦合到所述导电阱，其中所述第一位置和所述第二位置之间的距离小于所述第一长度，耦合到所述第一接触和所述第二接触的刺激电路，以及用于识别 指示通过导电井从第一位置到第二位置的电流路径的长度的特性。

公开(公告)号：US20100219810A1

公开(公告)日：2010-09-02

申请号：US12396288

申请日：2009-03-02

申请人： Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi

发明人： Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi

IPC分类号： H01L43/06 ,  H01L27/092 ,  H01L21/22

CPC分类号： H01L43/065 ,  G01R33/07 ,  G01R33/077 ,  H01L43/14

摘要： A complimentary metal oxide semiconductor (CMOS) sensor system in one embodiment includes a doped substrate, a doped central island extending downwardly within the doped substrate from an upper surface of the doped substrate, and a first doped outer island extending downwardly within the doped substrate from the upper surface of the doped substrate, the first outer island electrically isolated from the central island within an upper portion of the substrate, and electrically coupled to the central island within a lower portion of the substrate.

摘要翻译： 在一个实施例中，互补金属氧化物半导体（CMOS）传感器系统包括掺杂衬底，在掺杂衬底内从掺杂衬底的上表面向下延伸的掺杂中心岛，以及在掺杂衬底内向下延伸的第一掺杂外部岛， 掺杂衬底的上表面，第一外岛与衬底的上部内的中心岛电隔离，并且电耦合到衬底的下部内的中心岛。

公开(公告)号：US20100145657A1

公开(公告)日：2010-06-10

申请号：US12329961

申请日：2008-12-08

申请人： Sam Kavusi ,  Christoph Lang ,  Thomas Rocznik ,  Chinwuba Ezekwe

发明人： Sam Kavusi ,  Christoph Lang ,  Thomas Rocznik ,  Chinwuba Ezekwe

IPC分类号： G06F19/00 ,  H01L29/66

CPC分类号： G01R33/0029 ,  G01D18/008 ,  G01R33/072 ,  G01R33/075

摘要： A method and system for providing increased accuracy in a CMOS sensor system in one embodiment includes a plurality of sensor elements having a first terminal and a second terminal on a complementary metal oxide semiconductor substrate, a first plurality of switches configured to selectively connect the first terminal to a power source and to selectively connect the first terminal to a readout circuit, and a second plurality of switches configured to selectively connect the second terminal to the power source and to selectively connect the second terminal to the readout circuit.

摘要翻译： 在一个实施例中，在CMOS传感器系统中提供更高精度的方法和系统包括多个传感器元件，其具有在互补金属氧化物半导体衬底上的第一端子和第二端子，第一多个开关被配置为选择性地将第一端子 并且将第一端子选择性地连接到读出电路，以及第二多个开关，其被配置为选择性地将第二端子连接到电源并且将第二端子选择性地连接到读出电路。

公开(公告)号：US07492400B2

公开(公告)日：2009-02-17

申请号：US10858944

申请日：2004-06-01

申请人： Abbas El Gamal ,  Sam Kavusi

发明人： Abbas El Gamal ,  Sam Kavusi

IPC分类号： H04N3/14 ,  H04N5/335

CPC分类号： H04N5/3535 ,  H04N5/2351 ,  H04N5/2353 ,  H04N5/33

摘要： A new adaptive pixel architecture, folded-multiple-capture (FMC), integrates synchronous self-reset and multiple capture schemes and advantageously eliminates the requirement of a high-frame-rate sensor array, which is essential for conventional image sensors with high dynamic range. The FMC comprises a per-pixel analog-front-end (AFE), a fine analog-digital convertor (ADC) stage, and a digital-signal-processor/controller (DSPC) stage. The AFE performs programmable gain control, synchronous self-reset, sample-and-hold, and enables disturbance detection. In the AFE, a comparator compares an integrator output with a threshold voltage and produces a binary sequence accordingly. The ADC utilizes the binary sequence and the folded multiple capture signals to estimate photocurrent. An image sensor embodying the present invention adapts integration time to signal level, has minimal per-pixel hardware requirement, provides a very high dynamic range, about 120 dB or more, at high speed, about 1,000 frames/s or more, detects and corrects subframe disturbances, and consumes significantly less power.

摘要翻译： 一种新的自适应像素架构，折叠多重捕获（FMC），集成了同步自复位和多重捕获方案，有利地消除了高帧率传感器阵列的需求，这对于具有高动态范围的传统图像传感器至关重要 。 FMC包括每像素模拟前端（AFE），精细模拟数字转换器（ADC）级和数字信号处理器/控制器（DSPC）级。 AFE执行可编程增益控制，同步自复位，采样保持和启用干扰检测。 在AFE中，比较器将积分器输出与阈值电压进行比较，并相应地产生二进制序列。 ADC利用二进制序列和折叠的多个捕获信号来估计光电流。 体现本发明的图像传感器将积分时间适应于信号电平，具有最小的每像素硬件要求，以高速，约1,000帧/秒以上提供约120dB或更大的非常高的动态范围，检测和校正 子帧干扰，并消耗明显较少的功率。

公开(公告)号：US20080316347A1

公开(公告)日：2008-12-25

申请号：US10858944

申请日：2004-06-01

申请人： Abbas El Gamal ,  Sam Kavusi

发明人： Abbas El Gamal ,  Sam Kavusi

IPC分类号： H04N3/14

CPC分类号： H04N5/3535 ,  H04N5/2351 ,  H04N5/2353 ,  H04N5/33

摘要： A new adaptive pixel architecture, folded-multiple-capture (FMC), integrates synchronous self-reset and multiple capture schemes and advantageously eliminates the requirement of a high-frame-rate sensor array, which is essential for conventional image sensors with high dynamic range. The FMC comprises a per-pixel analog-front-end (AFE), a fine analog-digital convertor (ADC) stage, and a digital-signal-processor/controller (DSPC) stage. The AFE performs programmable gain control, synchronous self-reset, sample-and-hold, and enables disturbance detection. In the AFE, a comparator compares an integrator output with a threshold voltage and produces a binary sequence accordingly. The ADC utilizes the binary sequence and the folded multiple capture signals to estimate photocurrent. An image sensor embodying the present invention adapts integration time to signal level, has minimal per-pixel hardware requirement, provides a very high dynamic range, about 120 dB or more, at high speed, about 1,000 frames/s or more, detects and corrects subframe disturbances, and consumes significantly less power.

摘要翻译： 一种新的自适应像素架构，折叠多重捕获（FMC），集成了同步自复位和多重捕获方案，有利地消除了高帧率传感器阵列的需求，这对于具有高动态范围的传统图像传感器至关重要 。 FMC包括每像素模拟前端（AFE），精细模拟数字转换器（ADC）级和数字信号处理器/控制器（DSPC）级。 AFE执行可编程增益控制，同步自复位，采样保持和启用干扰检测。 在AFE中，比较器将积分器输出与阈值电压进行比较，并相应地产生二进制序列。 ADC利用二进制序列和折叠的多个捕获信号来估计光电流。 体现本发明的图像传感器将积分时间适应于信号电平，具有最小的每像素硬件要求，以高速，约1,000帧/秒以上提供约120dB或更大的非常高的动态范围，检测和校正 子帧干扰，并消耗明显较少的功率。

公开(公告)号：US11275084B2

公开(公告)日：2022-03-15

申请号：US12688193

申请日：2010-01-15

申请人： Sam Kavusi ,  Daniel Roser ,  Christoph Lang ,  AmirAli Haj Hossein Talasaz

发明人： Sam Kavusi ,  Daniel Roser ,  Christoph Lang ,  AmirAli Haj Hossein Talasaz

IPC分类号： B01L3/00 ,  G01N33/543 ,  C12Q1/6816

摘要： A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.

公开(公告)号：US20140113384A1

公开(公告)日：2014-04-24

申请号：US13658614

申请日：2012-10-23

申请人： Sam KAVUSI ,  Frederik Kotz

发明人： Sam KAVUSI ,  Frederik Kotz

IPC分类号： G01N33/53

CPC分类号： G01N33/561 ,  G01N33/54366

摘要： Lateral flow immunoassay devices for determining the concentration of an analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow immunoassay devices.

摘要翻译： 用于确定样品中分析物浓度的侧流免疫测定装置和使用这种侧流免疫测定装置测量样品中分析物浓度的方法。

公开(公告)号：US20140008244A1

公开(公告)日：2014-01-09

申请号：US13543300

申请日：2012-07-06

申请人： Sam KAVUSI ,  Rajan Gangadharan ,  Christopher Johnson ,  Aldrich N. K. Lau ,  Piyush Verma

发明人： Sam KAVUSI ,  Rajan Gangadharan ,  Christopher Johnson ,  Aldrich N. K. Lau ,  Piyush Verma

IPC分类号： G01N27/26 ,  B82Y99/00

CPC分类号： G01N33/50 ,  G01N27/3275 ,  G01N33/5306

摘要： Methods of modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological sample in a biosensor having a multisite array of test sites. In particular, the methods modulate the pH or ionic concentration gradient near the electrodes in such biosensor. The methods of modulating the binding interactions provide a biosensor and analytic methods for more accurately measuring an analyte of interest in a biological sample.

摘要翻译： 在生物传感器中调节生物样品中生物分子探针或检测剂与目的分析物之间的结合相互作用的方法，该生物传感器具有多个测试位点阵列。 特别地，该方法调节这种生物传感器中电极附近的pH或离子浓度梯度。 调节结合相互作用的方法提供了生物传感器和分析方法，用于更精确地测量生物样品中感兴趣的分析物。

公开(公告)号：US20120115236A1

公开(公告)日：2012-05-10

申请号：US13348727

申请日：2012-01-12

申请人： Michael Chen ,  Vincent Chen ,  Sam Kavusi ,  Christoph Lang

发明人： Michael Chen ,  Vincent Chen ,  Sam Kavusi ,  Christoph Lang

IPC分类号： G01N33/50

CPC分类号： G01N33/54393 ,  C08F20/56 ,  G01N33/5306 ,  Y10T436/11 ,  Y10T436/115831

摘要： A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a hydrogel composition loaded with a chemical factor at the test site, providing an actuator configured to activate the hydrogel composition to release a chemical factor at the test site, controlling the actuator to activate the hydrogel composition to release a chemical factor at the test site, and modifying the local chemical environment at the test site with the chemical factor.

摘要翻译： 在一个实施方案中间接改变测试部位的环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供装载有化学因子的水凝胶组合物，提供构造成将水凝胶组合物活化的致动器 在试验现场释放化学因子，控制致动器激活水凝胶组合物以释放在试验部位的化学因子，并用化学因子改变试验部位的局部化学环境。

公开(公告)号：US08114684B2

公开(公告)日：2012-02-14

申请号：US12396288

申请日：2009-03-02

申请人： Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi

发明人： Thomas Rocznik ,  Christoph Lang ,  Sam Kavusi

IPC分类号： H01L29/82 ,  H01L21/8238

CPC分类号： H01L43/065 ,  G01R33/07 ,  G01R33/077 ,  H01L43/14

摘要： A complementary metal oxide semiconductor (CMOS) sensor system in one embodiment includes a doped substrate, a doped central island extending downwardly within the doped substrate from an upper surface of the doped substrate, and a first doped outer island extending downwardly within the doped substrate from the upper surface of the doped substrate, the first outer island electrically isolated from the central island within an upper portion of the substrate, and electrically coupled to the central island within a lower portion of the substrate.

摘要翻译： 在一个实施例中，互补金属氧化物半导体（CMOS）传感器系统包括掺杂衬底，在掺杂衬底内从掺杂衬底的上表面向下延伸的掺杂中心岛，以及在掺杂衬底内向下延伸的第一掺杂外部岛， 掺杂衬底的上表面，第一外岛与衬底的上部内的中心岛电隔离，并且电耦合到衬底的下部内的中心岛。