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22 条记录 (耗时 0.038 秒)

    Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
    12.
    发明授权
    Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof 有权
    抗心律失常药物和心力衰竭药物，针对兰诺定受体（RyR2）的泄漏及其应用

    公开(公告)号：US07718644B2

    公开(公告)日：2010-05-18

    申请号：US10809089

    申请日：2004-03-25

    申请人： Andrew Robert Marks ,  Donald W. Landry ,  Shixian Deng ,  Zhen Zhuang Cheng

    发明人： Andrew Robert Marks ,  Donald W. Landry ,  Shixian Deng ,  Zhen Zhuang Cheng

    IPC分类号： A01N43/00 ,  A61K31/00

    CPC分类号： A61K31/554

    摘要： The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac death in a subject. Additionally, the present invention provides use of JTV-519 in a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject who has, or is a candidate for, atrial fibrillation. Also provided are uses of 1,4-benzothiazepine derivatives in methods for treating and preventing atrial and ventricular cardiac arrhythmias and heart failure in a subject, and for preventing exercise-induced sudden cardiac death. The present invention also provides methods for identifying agents for use in treating and preventing atrial fibrillation and heart failure, and agents identified by these methods.

    摘要翻译： 本发明提供限制或预防受试者中RyR2结合的FKBP12.6水平降低的方法。 本发明还提供了治疗和预防受试者心房心室心律失常心力衰竭和运动性心源性猝死的方法。 另外，本发明提供了用于限制或预防具有或已经是心房颤动候选者的受试者中RyR2结合的FKBP12.6的水平降低的方法中的JTV-519的用途。 还提供了1,4-苯并硫氮杂衍生物在治疗和预防受试者的心房心室心律失常和心力衰竭以及用于预防运动性心源性猝死的方法中的用途。 本发明还提供了用于鉴定用于治疗和预防心房颤动和心力衰竭的药剂的方法，以及通过这些方法鉴定的药剂。

    METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS
    13.
    发明申请
    METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS 审中-公开
    合成苯并噻唑化合物的方法

    公开(公告)号：US20090292119A1

    公开(公告)日：2009-11-26

    申请号：US12263435

    申请日：2008-10-31

    申请人： Donald W. Landry ,  Shixian Deng ,  Zhen Z. Cheng

    发明人： Donald W. Landry ,  Shixian Deng ,  Zhen Z. Cheng

    IPC分类号： C07D417/02 ,  C07D285/36 ,  C07D413/02

    CPC分类号： C07D281/10 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention provides improved methods for synthesizing novel benzothiazepine compounds. In particular, the invention relates to a new method that generally is used to make the substituted 2,3,4,5-tetrahydro-1,4-benzothiazepine compounds of a general formula which then may be used to make many other benzothiazepine compounds.

    摘要翻译： 本发明提供了合成新的苯并硫氮杂化合物的改进方法。 特别地，本发明涉及一种通常用于制备通式的取代的2,3,4,5-四氢-1,4-苯并硫氮杂化合物的新方法，其可用于制备许多其它苯并硫氮杂化合物。

    Phosphodiesterase inhibitors and uses thereof
    14.
    发明授权
    Phosphodiesterase inhibitors and uses thereof 有权
    磷酸二酯酶抑制剂及其用途

    公开(公告)号：US08697875B2

    公开(公告)日：2014-04-15

    申请号：US13167540

    申请日：2011-06-23

    申请人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

    发明人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

    IPC分类号： A61P25/00 ,  A61P25/28 ,  C07D215/44

    CPC分类号： A61K31/4706 ,  C07D215/48 ,  C07D215/54

    摘要： The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.

    摘要翻译： 本发明提供了磷酸二酯酶抑制剂的化合物。 本发明进一步提供了一种筛选结合并调节磷酸二酯酶蛋白质的化合物的方法。 本发明还提供了通过向受试者施用磷酸二酯酶结合化合物来治疗与累积的淀粉样蛋白-β肽沉积物积累相关的病症的方法。

    PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES
    16.
    发明申请
    PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES 有权
    从氨基 - 氨基苯甲腈制备苯并噻唑的方法

    公开(公告)号：US20090227788A1

    公开(公告)日：2009-09-10

    申请号：US12397212

    申请日：2009-03-03

    申请人： Shixian Deng ,  Sandro Belvedere ,  Jiaming Yan ,  Donald Landry

    发明人： Shixian Deng ,  Sandro Belvedere ,  Jiaming Yan ,  Donald Landry

    IPC分类号： C07D417/12 ,  C07D281/10

    CPC分类号： C07D281/02 ,  C07D281/10 ,  C07D513/04 ,  Y02P20/55

    摘要： The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formula then treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.

    摘要翻译： 本发明提供了制备下式的2,3,4,5-四氢[1,4]苯并硫氮杂的方法：通过使式的[2-（酰基氨基乙基）硫代]芳烃或其多聚体与 酸。 本发明还提供了使[2-（酰基氨基乙基）硫代]芳烃与其醛或多聚体和碱反应以形成式的[N-羟甲基-2- [酰氨基乙基]硫代]芳烃，然后将[N- 羟基甲基-2-（酰氨基乙基）硫代]芳烃与酸形成2,3,4,5-四氢[1,4]苯并硫氮杂。

    Novel agents for preventing and treating disorders involving modulation of the RyR receptors
    17.
    发明申请
    Novel agents for preventing and treating disorders involving modulation of the RyR receptors 有权
    用于预防和治疗涉及RyR受体调节的疾病的新型药剂

    公开(公告)号：US20070049572A1

    公开(公告)日：2007-03-01

    申请号：US11212413

    申请日：2005-08-25

    申请人： Andrew Marks ,  Donald Landry ,  Shixian Deng ,  Zhen Cheng ,  Stephan Lehnart

    发明人： Andrew Marks ,  Donald Landry ,  Shixian Deng ,  Zhen Cheng ,  Stephan Lehnart

    IPC分类号： C07D291/08 ,  A61K31/554

    CPC分类号： C07D281/10 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome. Cardiac disorder and diseases include, but are not limited to, irregular heartbeat disorders and diseases; exercise-induced irregular heartbeat disorders and diseases; sudden cardiac death; exercise-induced sudden cardiac death; congestive heart failure; chronic obstructive pulmonary disease; and high blood pressure. Irregular heartbeat disorders and diseases include and exercise-induced irregular heartbeat disorders and diseases include, but are not limited to, atrial and ventricular arrhythmia; atrial and ventricular fibrillation; atrial and ventricular tachyarrhythmia; atrial and ventricular tachycardia; catecholaminergic polymorphic ventricular tachycardia (CPVT); and exercise-induced variants thereof. Skeletal muscular disorder and diseases include, but are not limited to, skeletal muscle fatigue, exercise-induced skeletal muscle fatigue, muscular dystrophy, bladder disorders, and incontinence. Cognitive disorders and diseases include, but are not limited to, Alzheimer's Disease, forms of memory loss, and age-dependent memory loss.

    摘要翻译： 本发明提供新的式I化合物及其盐，水合物，溶剂合物，络合物和前药。 本发明还提供了合成式I化合物的方法。本发明另外提供包含式I化合物的药物组合物和使用式I药物组合物的方法，以治疗和预防与调节钙的RyR受体相关的疾病和疾病 通道在单元格中起作用。 这样的疾病和疾病仅包括心脏病和疾病，骨骼肌障碍和疾病，认知障碍和疾病，恶性高热，糖尿病和婴儿猝死综合征。 心脏疾病和疾病包括但不限于不规则的心跳障碍和疾病; 运动引起的心律失常和疾病不规律; 心脏猝死; 运动性心源性猝死; 充血性心力衰竭; 慢性阻塞性肺疾病; 和高血压。 不规律的心跳疾病和疾病包括运动诱发的心律失常和疾病的疾病包括但不限于心房和室性心律失常; 心房和心室颤动; 心房和心室快速性心律失常; 心房和室性心动过速; 儿茶酚胺能多态性室性心动过速（CPVT）; 和运动诱发的变体。 骨骼肌障碍和疾病包括但不限于骨骼肌疲劳，运动引起的骨骼肌疲劳，肌营养不良，膀胱障碍和失禁。 认知障碍和疾病包括但不限于阿尔茨海默病，记忆丧失的形式和年龄依赖性记忆丧失。

    Agents for preventing and treating disorders involving modulation of the ryanodine receptors
    19.
    发明授权
    Agents for preventing and treating disorders involving modulation of the ryanodine receptors 有权
    用于预防和治疗涉及调节兰诺定受体的疾病的药剂

    公开(公告)号：US08710045B2

    公开(公告)日：2014-04-29

    申请号：US12938098

    申请日：2010-11-02

    申请人： Andrew Robert Marks ,  Donald W. Landry ,  Shixian Deng

    发明人： Andrew Robert Marks ,  Donald W. Landry ,  Shixian Deng

    IPC分类号： A61P9/00 ,  A61K31/553 ,  A61K31/554 ,  C07D281/02

    CPC分类号： C07D281/10 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.

    摘要翻译： 本发明提供式I化合物及其盐，水合物，溶剂合物，络合物和前药。 本发明还提供了合成式I化合物的方法。本发明另外提供包含式I化合物的药物组合物和使用式I药物组合物的方法，以治疗和预防与调节钙的RyR受体相关的疾病和疾病 通道在单元格中起作用。