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13 条记录 (耗时 0.055 秒)

    Phosphodiesterase inhibitors and uses thereof
    2.
    发明授权
    Phosphodiesterase inhibitors and uses thereof 有权
    磷酸二酯酶抑制剂及其用途

    公开(公告)号：US08697875B2

    公开(公告)日：2014-04-15

    申请号：US13167540

    申请日：2011-06-23

    申请人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

    发明人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

    IPC分类号： A61P25/00 ,  A61P25/28 ,  C07D215/44

    CPC分类号： A61K31/4706 ,  C07D215/48 ,  C07D215/54

    摘要： The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.

    摘要翻译： 本发明提供了磷酸二酯酶抑制剂的化合物。 本发明进一步提供了一种筛选结合并调节磷酸二酯酶蛋白质的化合物的方法。 本发明还提供了通过向受试者施用磷酸二酯酶结合化合物来治疗与累积的淀粉样蛋白-β肽沉积物积累相关的病症的方法。

    Cell cultures from animal models of Alzheimer's disease for screening and testing drug efficacy
    9.
    发明申请
    Cell cultures from animal models of Alzheimer's disease for screening and testing drug efficacy 审中-公开
    来自阿尔茨海默病动物模型的细胞培养物用于筛选和测试药物功效

    公开(公告)号：US20050172344A1

    公开(公告)日：2005-08-04

    申请号：US10980922

    申请日：2004-11-03

    申请人： Ottavio Arancio ,  Paul Mathews ,  Stephen Schmidt ,  Ralph Nixon ,  Fortunato Battaglia ,  Fabrizio Trinchese ,  Shumin Liu

    发明人： Ottavio Arancio ,  Paul Mathews ,  Stephen Schmidt ,  Ralph Nixon ,  Fortunato Battaglia ,  Fabrizio Trinchese ,  Shumin Liu

    IPC分类号： A01K67/027 ,  C12N5/06 ,  G01N33/50 ,  G01N33/68

    CPC分类号： G01N33/502 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5058 ,  G01N33/6896

    摘要： The present invention describes a dissociated cell culture system comprising cells of the hippocampus, one of the brain areas affected by Alzheimer's Disease (AD) or amyloid beta-related diseases. This culture system comprises hippocampal neuronal and glial cells from animal models of AD, particularly, but not limited to, double transgenic mice expressing both the human APP mutation (K670N:M671L) (mAPP), and the human PS1 mutation (M146L) (mPS1), and serves as a powerful tool for the screening and testing of compounds and substances, e.g., drugs, for their ability to affect, treat, or prevent AD or β-amyloid-related diseases. The effects of a test substance on the cells in this culture system can be quantitatively assessed to determine if the test substance affects the cells biochemically and/or electrophysiologically, and/or optically, and/or immunocytochemically. The present in vitro culture system is advantageous for AD drug screening, because it is rapid and efficient. By contrast, even in the fastest animal model of AD, pathology does not start before the end of the second month. If such in vivo animal models are used, it is necessary to wait at least the two month time duration or longer to test for drug efficacy for AD treatment or prevention. At the same time the present invention provides a tool for production of amyloid-beta that can be used for electrophysiological, behavioral, and toxicological studies.

    摘要翻译： 本发明描述了解离的细胞培养系统，其包括海马细胞，受阿尔茨海默病（AD）或淀粉样蛋白β相关疾病影响的脑区之一。 该培养系统包括来自AD的动物模型的海马神经元和神经胶质细胞，特别但不限于表达人APP突变（K670N：M671L）（mAPP）和人PS1突变（M146L）（mP1）的双转基因小鼠 ），并且用作筛选和测试化合物和物质（例如药物）对其影响，治疗或预防AD或β-淀粉样蛋白相关疾病的能力的有力工具。 可以定量评估测试物质对该培养系统中细胞的影响，以确定测试物质是否通过生物化学和/或电生理学和/或光学和/或免疫细胞化学方法影响细胞。 目前的体外培养体系对于AD药物筛选是有利的，因为它是快速和有效的。 相比之下，即使在AD的最快动物模型中，病理学也不会在第二个月之前开始。 如果使用这样的体内动物模型，则需要等待至少两个月的持续时间或更长时间来测试AD治疗或预防的药物功效。 同时，本发明提供了可用于电生理，行为和毒理学研究的淀粉样蛋白-β生产工具。

    USES OF HISTONE ACETYLTRANSFERASE ACTIVATORS
    10.
    发明申请
    USES OF HISTONE ACETYLTRANSFERASE ACTIVATORS 有权
    乙酰胆碱酯酶活化剂的使用

    公开(公告)号：US20140350116A1

    公开(公告)日：2014-11-27

    申请号：US14125214

    申请日：2012-06-11

    申请人： Yitshak Francis ,  Ottavio Arancio ,  Mauro Fa

    发明人： Yitshak Francis ,  Ottavio Arancio ,  Mauro Fa

    IPC分类号： C07C237/44

    CPC分类号： C07C237/44 ,  A61K31/167

    摘要： The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了在化合物（I）或包含化合物（I）或其药学上可接受的盐的组合物的组合物中增强组蛋白酰化，学习，记忆和/或认知的方法。