公开(公告)号：US20170121276A1

公开(公告)日：2017-05-04

申请号：US13996483

申请日：2011-12-22

申请人： Yitshak FRANCIS ,  Mauro FA ,  Ottavio ARANCIO ,  Jole FIORITO ,  Shixian DENG ,  Donald W. LANDRY ,  Michal LUZAC ,  Yan FENG

发明人： Yitshak FRANCIS ,  Mauro FA ,  Ottavio ARANCIO ,  Jole FIORITO ,  Shixian DENG ,  Donald W. LANDRY ,  Michal LUZAC ,  Yan FENG

IPC分类号： C07C217/22 ,  C07D295/088 ,  C07D265/14 ,  C07D209/48

CPC分类号： C07C217/22 ,  C07C217/58 ,  C07C235/60 ,  C07C235/64 ,  C07C251/24 ,  C07D209/48 ,  C07D265/14 ,  C07D265/36 ,  C07D295/088

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

公开(公告)号：US20130121919A1

公开(公告)日：2013-05-16

申请号：US13493490

申请日：2012-06-11

申请人： Yan FENG ,  Mauro Fa ,  Ottavio Arancio ,  Shi Xian Deng ,  Donald W. Landry ,  Yitshak Francis

发明人： Yan FENG ,  Mauro Fa ,  Ottavio Arancio ,  Shi Xian Deng ,  Donald W. Landry ,  Yitshak Francis

IPC分类号： C07C235/64 ,  C07C323/42 ,  C07D213/82 ,  C07D213/75 ,  C12Q1/48 ,  C07C237/40 ,  C07D239/52 ,  C07D333/38 ,  A61K49/00 ,  C07C323/67 ,  C07C235/56

CPC分类号： C07C235/64 ,  A61K49/00 ,  C07C235/56 ,  C07C237/40 ,  C07C323/42 ,  C07C323/44 ,  C07C323/60 ,  C07C323/67 ,  C07C2601/08 ,  C07D213/75 ,  C07D213/82 ,  C07D239/52 ,  C07D333/38 ,  C12Q1/48 ,  G01N2500/04 ,  G01N2800/2814

摘要： The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

摘要翻译： 本发明提供了筛选结合并调节组蛋白乙酰转移酶蛋白的化合物的方法。 本发明还提供了通过向受试者施用HAT激活化合物来治疗神经变性疾病，与累积的淀粉样蛋白-β肽沉积相关的病症，Tau蛋白水平和/或α-突触核蛋白的积累以及癌症的方法。

公开(公告)号：US20200174243A1

公开(公告)日：2020-06-04

申请号：US16465451

申请日：2017-08-24

申请人： Yan FENG

发明人： Yan FENG

IPC分类号： G02B21/36 ,  G02B21/16 ,  G02B27/42

摘要： Disclosed is a four-dimensional (4D: 3D+time) multi-plane broadband imaging apparatus capable of recording 3D multi-plane and multi-colour images simultaneously. The apparatus comprises: one or more non-reentry quadratically distorted (NRQD) gratings (5) which can produce a focal length and a spatial position corresponding to each diffraction order, thus simultaneously transmitting wavefront information between multiple object/image planes (2) and a single image/object plane (7); a grism system (4) which can limit chromatically-induced lateral smearing by creating a collimated beam in which the spectral components are laterally displaced; a lens system (3) which is configured to adjust the optical path; and the optical detector(s) (6). In an optical system, the multiple object/image planes (2), the lens system (3), the grism system (4), the NRQD grating(s) (5), the optical detector(s) (6) and the single image/object plane (7) are located on the same optical axis (1). This simple, easy-to-use and compact apparatus can meet many different requirements and serve a large range of high throughput applications.

公开(公告)号：US20090306259A1

公开(公告)日：2009-12-10

申请号：US12541918

申请日：2009-08-15

申请人： Changfa XIAO ,  Naiku XU ,  Shulin AN ,  Yan FENG ,  Guangxia JIA

发明人： Changfa XIAO ,  Naiku XU ,  Shulin AN ,  Yan FENG ,  Guangxia JIA

IPC分类号： C08K5/41 ,  C08L31/02 ,  C08K5/20

CPC分类号： D01F6/36 ,  D01F1/02

摘要： A method of preparing oil-absorbing fibers by: a) fully dissolving a dispersant and a deionized water in a reaction vessel, adding a methacrylate monomer and an initiator to a reactor and stirring to form a homogenous solution, transferring the homogenous solution into the reaction vessel, charging nitrogen gas, stirring, raising temperature to 70-80° C., allowing to react for 2-6 hours, raising temperature to 90-100° C., allowing to react for 2-4 hours, collecting a resultant product, washing, drying, and obtaining a white resin; b) drying the white resin, mixing with a swelling agent, and sealing the mixture at room temperature for 48-96 hours to yield a homogenous gel; c) grinding the gel completely, spinning by a plunger spinner, and coagulating with a coagulation bath to yield an as-spun oil-absorbing fiber; and d) drawing the as-spun oil-absorbing fiber with a draw ratio of 2-6 to yield oil-absorbing fibers.

摘要翻译： 一种通过以下步骤制备吸油纤维的方法：a）将分散剂和去离子水完全溶解在反应容器中，向反应器中加入甲基丙烯酸酯单体和引发剂并搅拌形成均匀溶液，将均匀溶液转移到反应器 容器中，加氮，搅拌，升温至70-80℃，反应2-6小时，升温至90-100℃，反应2-4小时，收集所得产物 ，洗涤，干燥，得到白色树脂; b）干燥白色树脂，与溶胀剂混合，并将混合物在室温下密封48-96小时，得到均匀的凝胶; c）完全研磨凝胶，通过柱塞旋转器纺丝，并用凝固浴凝结，得到一种吸水纤维; 和d）以2:1的拉伸比拉伸吸水纤维，得到吸油纤维。