公开(公告)号：US20120009207A1

公开(公告)日：2012-01-12

申请号：US13107504

申请日：2011-05-13

Applicant: Li-Te CHIN ,  Shu-Ching Hsu

Inventor： Li-Te CHIN ,  Shu-Ching Hsu

IPC: A61K35/14 ,  A61P37/06

CPC classification number: A61K35/26 ,  A61K38/17 ,  C07K16/2818 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/505

Abstract: The present invention provides a CTLA-4 non-blocking agent of a complete human antibody nature, thus is non-immunogenic in a human. The immunoassay method using such a non-blocking agent measures the CTLA-4 content in a sample of a human subject. The present invention further provides a novel method for isolating human regulatory T cells. The resultant enriched and depleted cellular populations are useful in treating or ameliorating of human diseases.

Abstract translation: 本发明提供了完全人抗体性质的CTLA-4非阻断剂，因此在人体中是非免疫原性的。 使用这种非阻断剂的免疫测定方法测量人受试者样品中的CTLA-4含量。 本发明还提供了一种分离人类调节性T细胞的新方法。 所产生的富含和消耗的细胞群可用于治疗或改善人类疾病。

公开(公告)号：US20050268153A1

公开(公告)日：2005-12-01

申请号：US11101720

申请日：2005-04-07

Applicant: Joseph Armstrong ,  Shu-Ching Hsu ,  Miriyala Sreekanth

Inventor： Joseph Armstrong ,  Shu-Ching Hsu ,  Miriyala Sreekanth

IPC: G06F11/00 ,  G06F11/07 ,  G06F15/177

CPC classification number: G06F11/0709 ,  G06F11/0793 ,  G06F11/1425 ,  G06F11/1482 ,  H04L43/0811 ,  H04L43/10

Abstract: In a cluster system comprising at least two nodes connected via a communication network and having a name and a host weight assigned to it, a method is implemented comprising the steps of inspecting the communication link, determining which node has to be shut down after a failure, creating an advertisement report for the node to be shut down, sending the advertisement report to at least one node of the cluster system, calculating a delay time depending on the weight of the first node and sending the shut down command to the node for which a failure report was received. In one embodiment of the invention the advertisement reports include a master node, which allows identifying and specifying the surviving subcluster. The method will send shut down signals to those nodes of a subcluster with lower weight than the surviving subcluster. A failsafe mechanism is implemented.

Abstract translation: 在包括通过通信网络连接并具有分配给它的名称和主机权重的至少两个节点的集群系统中，实现一种方法，包括检查通信链路的步骤，确定哪个节点必须在故障之后被关闭 创建关闭节点的广告报告，将广告报告发送给集群系统的至少一个节点，根据第一个节点的权重计算延迟时间，并向其节点发送关闭命令， 收到失败报告。 在本发明的一个实施例中，广告报告包括主节点，其允许识别和指定幸存子集群。 该方法将发送关闭信号到具有比剩余子集群更低的权重的子集群的那些节点。 实施故障安全机制。

公开(公告)号：US20150126714A1

公开(公告)日：2015-05-07

申请号：US14526842

申请日：2014-10-29

Applicant: Li-Te CHIN ,  Shu-Ching HSU ,  Kai-Chen WANG

Inventor： Li-Te CHIN ,  Shu-Ching HSU ,  Kai-Chen WANG

IPC: C07K16/18

CPC classification number: C07K16/24 ,  A61K2039/505 ,  C07K2317/76

Abstract: The present invention relates to methods of making human anti-HMGB1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions in HMGB1 associated-neuropathy.

Abstract translation: 本发明涉及制备人抗HMGB1抗体的方法，包含这些抗体的组合物和在HMGB1相关神经病变中使用抗体和组合物的方法。

公开(公告)号：US20130267688A1

公开(公告)日：2013-10-10

申请号：US13327752

申请日：2012-02-21

Applicant: Li-Te Chin ,  Chishih Chu ,  Shu Ching Hsu

Inventor： Li-Te Chin ,  Chishih Chu ,  Shu Ching Hsu

IPC: C07K16/28

CPC classification number: C07K16/2818 ,  C07K2317/21

Abstract: In order to provide necessary information for the production of complete human monoclonal antibodies capable of human CD152 (CTLA-4) binding, the primary structures of heavy and light chains have been elucidated. The novel amino acid sequence of identified heavy and light chains are derived from VH3 and Vλ germline genes, respectively. Antibodies comprising such novel structures cause specific binding to soluble recombinant human CD152 as well as to activated human peripheral T cells, where the expression of CD152 has been elevated.

Abstract translation: 为了提供生产能够进行人CD152（CTLA-4）结合的完整人单克隆抗体的必要信息，已经阐明了重链和轻链的一级结构。 鉴定的重链和轻链的新氨基酸序列分别衍生自VH3和Vlambda种系基因。 包含这种新型结构的抗体引起与可溶性重组人CD152的特异性结合以及CD152的表达升高的活化的人外周T细胞。

公开(公告)号：US08158386B2

公开(公告)日：2012-04-17

申请号：US12888713

申请日：2010-09-23

Applicant: Li-Te Chin ,  Shu-Ching Hsu

Inventor： Li-Te Chin ,  Shu-Ching Hsu

IPC: G01N33/567

CPC classification number: G01N33/5052 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2818 ,  C07K2317/73 ,  C07K2317/74 ,  G01N33/505 ,  G01N33/6854 ,  G01N2333/70521

Abstract: A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.

Abstract translation: 公开了一种获得给定生理受体的激动剂，拮抗剂和反向激动剂的方法。 对于该方法，使用计算机设计合成免疫原，其在体外对人类含淋巴细胞的细胞群体起作用。 优选的受体是人CD152，特别是分别引发作为拮抗剂，反向激动剂和激动剂的抗体的CDR1，CDR2和CDR3的区域。 还提供了治疗人外周淋巴细胞用于筛选产生药理作用的CD152配体的方法。

公开(公告)号：US07494779B2

公开(公告)日：2009-02-24

申请号：US10866120

申请日：2004-06-14

Applicant: Li-Te Chin ,  Shu-Ching Hsu

Inventor： Li-Te Chin ,  Shu-Ching Hsu

IPC: G01N33/53

CPC classification number: G01N33/5052 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2818 ,  C07K2317/73 ,  C07K2317/74 ,  G01N33/505 ,  G01N33/6854 ,  G01N2333/70521

Abstract: A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.

Abstract translation: 公开了一种获得给定生理受体的激动剂，拮抗剂和反向激动剂的方法。 对于该方法，使用计算机设计合成免疫原，其在体外对人类含淋巴细胞的细胞群体起作用。 优选的受体是人CD152，特别是分别引发作为拮抗剂，反向激动剂和激动剂的抗体的CDR1，CDR2和CDR3的区域。 还提供了治疗人外周淋巴细胞用于筛选产生药理作用的CD152配体的方法。

公开(公告)号：US20070236928A1

公开(公告)日：2007-10-11

申请号：US11401438

申请日：2006-04-11

Applicant: Shu-Ching Hsu

Inventor： Shu-Ching Hsu

IPC: F21V9/00

CPC classification number: A44C15/0015

Abstract: A light emitting decoration has a decoration unit having a colored and lighting decoration; the colored and lighting decoration being capable of refracting light as light passing therethrough; a light emitting unit having at least one transmission line which is bendable to be formed as a figure or characters; the transmission line being installed with a plurality of light emitting elements; the transmission line being wound and adhered to the colored and lighting decoration. The decoration has a ring which can be worn around a finger of a user. The light emitting unit has a control circuit board with predetermined control way; the control circuit board is installed with a battery as a power source and a switch key.

Abstract translation: 发光装饰具有装饰单元，具有彩色和照明装饰; 彩色和照明装饰能够通过光线折射光; 发光单元，其具有可弯曲形成为图形或字符的至少一条传输线; 所述传输线安装有多个发光元件; 传输线被缠绕并粘附到彩色和照明装饰上。 该装饰具有能够佩戴在使用者的手指周围的环。 发光单元具有预定控制方式的控制电路板; 控制电路板安装有电池作为电源和开关键。

公开(公告)号：US20070236916A1

公开(公告)日：2007-10-11

申请号：US11401439

申请日：2006-04-11

Applicant: Shu-Ching Hsu

Inventor： Shu-Ching Hsu

IPC: F21V21/08

CPC classification number: A41C3/00 ,  A41B9/002 ,  A41D27/085

Abstract: A pair of light emitting knickers comprises a pair of knickers having an edge strip; a light emitting unit being installed on the edge strip of the knickers through a combining unit; the light emitting unit including a flexible transmission line; the transmission line being bendable to be as characters or patterns on the edge strip; the transmission line being installed with a plurality of light emitting elements; a combining unit for combining the light emitting unit to the edge strip; wherein by the light emitting unit, the knickers can light up by actuating the light emitting elements of the light emitting unit. The light emitting unit has a control circuit board with a predetermined control way; and the control circuit board is installed with batteries and control switches. Moreover the light emitting unit can be used to a brassiere.

Abstract translation: 一对发光纽扣包括一对具有边缘条的短裤; 发光单元，其通过组合单元安装在所述短裤的边缘条上; 所述发光单元包括柔性传输线; 传输线可弯曲成边缘条上的字符或图案; 所述传输线安装有多个发光元件; 组合单元，用于将发光单元与边缘条组合; 其中，通过发光单元，可以通过致动发光单元的发光元件来点亮灯头。 发光单元具有预定控制方式的控制电路板; 控制电路板上装有电池和控制开关。 此外，发光单元可以用于胸罩。

公开(公告)号：US20070208844A1

公开(公告)日：2007-09-06

申请号：US11685485

申请日：2007-03-13

Applicant: Joseph Armstrong ,  Shu-Ching Hsu ,  Mark Johnston ,  Rahul Kelkar ,  Judy King ,  Brian Kress ,  Radhika Pennepalli ,  Kesava Pulijala ,  Guangji Shen ,  Pushkar Singh ,  Kevin Stoner ,  Rajendran Vishwanathan

Inventor： Joseph Armstrong ,  Shu-Ching Hsu ,  Mark Johnston ,  Rahul Kelkar ,  Judy King ,  Brian Kress ,  Radhika Pennepalli ,  Kesava Pulijala ,  Guangji Shen ,  Pushkar Singh ,  Kevin Stoner ,  Rajendran Vishwanathan

IPC: G06F15/173

CPC classification number: G06F9/505 ,  G06F9/4843 ,  G06F9/50 ,  G06F2209/508 ,  H04L41/0896 ,  H04L67/1002 ,  H04L67/1008 ,  H04L67/16 ,  H04L67/42

Abstract: A computer arrangement for providing services to clients over a network includes: at least two servers, each server hosting at least one application, an automated administrator configured to automatically provision the servers to provide the services, and at least one network load balancer connected to the clients and the servers. The network load balancer is responsible for at least one of the services and is configured to gather state information on the state of the servers and/or the applications hosted on the servers and is operable to route incoming requests of clients to at least one of the servers. The network load balancer provides the automated administrator with the state information. The automated administrator provides the network load balancer with provisioning information regarding which servers are provisioned to provide the at least one service for which the network load balancer is responsible.

Abstract translation: 用于通过网络向客户端提供服务的计算机装置包括：至少两个服务器，托管至少一个应用的每个服务器，被配置为自动配置服务器以提供服务的自动管理器，以及至少一个网络负载平衡器 客户端和服务器。 所述网络负载平衡器负责所述服务中的至少一个，并且被配置为收集关于所述服务器和/或所述服务器上托管的应用的状态的状态信息，并且可操作地将客户端的传入请求路由到所述服务器中的至少一个 服务器 网络负载平衡器为自动管理员提供状态信息。 自动管理员为网络负载平衡器提供关于哪些服务器被配置以提供网络负载均衡器负责的至少一个服务的供应信息。

公开(公告)号：US20050277173A1

公开(公告)日：2005-12-15

申请号：US10866120

申请日：2004-06-14

Applicant: Li-Te Chin ,  Shu-Ching Hsu

Inventor： Li-Te Chin ,  Shu-Ching Hsu

IPC: C07H21/04 ,  C07K16/00 ,  C07K16/28 ,  C12N5/06 ,  C12P21/06 ,  G01N33/48 ,  G01N33/50 ,  G01N33/68 ,  G06F19/00

CPC classification number: G01N33/5052 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2818 ,  C07K2317/73 ,  C07K2317/74 ,  G01N33/505 ,  G01N33/6854 ,  G01N2333/70521

Abstract: A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDRl, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.

Abstract translation: 公开了一种获得给定生理受体的激动剂，拮抗剂和反向激动剂的方法。 对于该方法，使用计算机设计合成免疫原，其在体外对人类含淋巴细胞的细胞群体起作用。 优选的受体是人CD152，特别是分别引发作为拮抗剂，反向激动剂和激动剂的抗体的CDR1，CDR2和CDR3的区域。 还提供了治疗人外周淋巴细胞用于筛选产生药理作用的CD152配体的方法。