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公开(公告)号：US20110077964A1
公开(公告)日：2011-03-31
申请号：US12992169
申请日：2009-05-06
申请人： Angel J. Janevski , Nevenka Dimitrova , Sitharthan Kamalakaran , Yasser Alsafadi , Nilanjana Banerjee , Anca Ioana Daniela Bacur , Jasper Van Leeuwen , Vinay Varadan
发明人： Angel J. Janevski , Nevenka Dimitrova , Sitharthan Kamalakaran , Yasser Alsafadi , Nilanjana Banerjee , Anca Ioana Daniela Bacur , Jasper Van Leeuwen , Vinay Varadan
IPC分类号： G06Q50/00
摘要： The present invention relates to effective diagnosis of patients and assisting clinicians in treatment planning. In particular, invention provides a medical analysis system that enables refinement of molecular classification. The system provides a molecular profiling solution that will allow improved diagnosis, prognosis, response prediction to provide the right chemotherapy, and follow-up to monitor for cancer recurrence.
摘要翻译： 本发明涉及患者的有效诊断，并协助临床医师进行治疗计划。 特别地，本发明提供了能够细化分子分类的医学分析系统。 该系统提供了一个分子谱分析解决方案，可以改进诊断，预后，反应预测，提供正确的化学疗法和随访监测癌症复发。
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公开(公告)号：US20100273674A1
公开(公告)日：2010-10-28
申请号：US12678423
申请日：2008-09-16
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： The invention relates to a method for the analysis of ovarian cancer disorders, comprising determining the genomic methylation status of one or more CpG dinucleotides in a sequence selected from the group of sequences according to SEQ ID NO. 1 to 10 and/or SEQ ID NO. 50 to SEQ ID NO. 60. Optionally, additionally following steps are performed, the one or more results from the methylation status test is input into a classifier that is obtained from a Diagnostic Multi Variate Model, calculating a likelihood as to whether the sample is from a normal tissue or an ovarian cancer tissue and/or, calculating an associated p-value for the confidence in the prediction.
摘要翻译： 本发明涉及一种用于分析卵巢癌病症的方法，包括确定一种或多种CpG二核苷酸的基因组甲基化状态，所述序列选自SEQ ID NO。 1至10和/或SEQ ID NO。 50至SEQ ID NO。 可选地，另外执行以下步骤，将来自甲基化状态测试的一个或多个结果输入到从诊断多变量模型获得的分类器中，计算样品是来自正常组织或 卵巢癌组织和/或计算预测中置信度的相关p值。
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公开(公告)号：US10342454B2
公开(公告)日：2019-07-09
申请号：US14112664
申请日：2012-04-16
摘要： A medical device and methods for locating the device include a structure having a length dimension and a surface (102). A volume (106) is associated with the surface and extends along a portion of the length dimension. Nanomaterials (108) are incorporated in the volume and configured to be responsive to an excitation signal such that the excitation signal generates a response from the nanomaterials to enable location of the structure within a subject.
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公开(公告)号：US08652777B2
公开(公告)日：2014-02-18
申请号：US12678423
申请日：2008-09-16
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： The invention relates to a method for the analysis of ovarian cancer disorders, comprising determining the genomic methylation status of one or more CpG dinucleotides in a sequence selected from the group of sequences according to SEQ ID NO. 1 to 10 and/or SEQ ID NO. 50 to SEQ ID NO. 60. Optionally, additionally following steps are performed, the one or more results from the methylation status test is input into a classifier that is obtained from a Diagnostic Multi Variate Model, calculating a likelihood as to whether the sample is from a normal tissue or an ovarian cancer tissue and/or, calculating an associated p-value for the confidence in the prediction.
摘要翻译： 本发明涉及一种用于分析卵巢癌病症的方法，包括确定一种或多种CpG二核苷酸的基因组甲基化状态，所述序列选自SEQ ID NO。 1至10和/或SEQ ID NO。 50至SEQ ID NO。 可选地，另外执行以下步骤，将来自甲基化状态测试的一个或多个结果输入到从诊断多变量模型获得的分类器中，计算样品是来自正常组织或 卵巢癌组织和/或计算预测中置信度的相关p值。
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公开(公告)号：US20120004118A1
公开(公告)日：2012-01-05
申请号：US13147105
申请日：2010-01-25
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/112 , C12Q2600/154 , Y10T436/143333 , C12Q2537/165
摘要： Provided is a method for the analysis of breast cancer disorders, comprising determining the genomic methylation status of one or more CpG dinucleotides. Furthermore, a computer program product stored on a computer-readable medium comprising software code adapted to perform the steps of the method when executed on a data-processing apparatus is provided. A device comprising means for supporting a clinician is also provided.
摘要翻译： 提供了一种用于分析乳腺癌病症的方法，包括测定一种或多种CpG二核苷酸的基因组甲基化状态。 此外，提供了存储在计算机可读介质上的计算机程序产品，其包括适于在数据处理装置上执行时执行所述方法的步骤的软件代码。 还提供了一种包括用于支撑临床医生的装置的装置。
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