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公开(公告)号：US20080312427A1
公开(公告)日：2008-12-18
申请号：US11954009
申请日：2007-12-11
Applicant: Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
Inventor： Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
IPC: C07H21/00
Abstract: A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particle generated by the methods of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.
Abstract translation: 描述了将发光报告基团与生物分子与核苷酸寡聚体连接的方法。 在将生物分子共价连接到光报告颗粒之前，光报告颗粒被甲硅烷基化和官能化以产生包被的光报告颗粒。 通过本发明方法产生的光报告颗粒可以通过诸如UV或IR光的光激发源激发，并且当生物分子是DNA时，通过诸如PCR的扩增技术检测所连接的DNA分子。
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Patent Agency Ranking
公开(公告)号：US20080299559A1
公开(公告)日：2008-12-04
申请号：US11954038
申请日：2007-12-11
Applicant: Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
Inventor： Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
IPC: C12Q1/68
CPC classification number: C12Q1/6816 , C08K5/09 , C09D7/63 , C09D11/03 , Y10T436/14 , Y10T436/143333 , Y10T442/2508 , C12Q2563/185
Abstract: This invention pertains to methods for authenticating an article comprising tagging the article with light emitting optical reporter particles, and more specifically tagging the articles with up-converting phosphor particles (UCP), linked to nucleic acids of detectable sequence.
Abstract translation: 本发明涉及用于认证物品的方法，所述方法包括使用发光光学报告物颗粒标记物品，更具体地，用与可检测序列的核酸连接的上转换磷光体颗粒（UCP）标记物品。
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公开(公告)号：US08940485B2
公开(公告)日：2015-01-27
申请号：US12269757
申请日：2008-11-12
Applicant: Ming-Hwa Liang , Stephane Shu Kin So
Inventor： Ming-Hwa Liang , Stephane Shu Kin So
IPC: C12Q1/68
CPC classification number: C12Q1/6895 , C12Q2600/13 , C12Q2600/156
Abstract: Methods for distinguishing between cotton cultivars of a specific species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the cultivar of a particular cotton species utilized in the textile or cotton material of interest.
Abstract translation: 公开了通过从原棉材料或纺织品分析成熟棉纤维样品来区分特定物种的棉花品种的方法。 从成熟棉花纤维样品中提取DNA，并进行PCR技术，其能够鉴定在感兴趣的纺织品或棉花材料中使用的特定棉花品种的品种。
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14.发明授权公开(公告)号：US08669079B2
公开(公告)日：2014-03-11
申请号：US12269737
申请日：2008-11-12
Applicant: Ming-Hwa Liang , Stephane Shu Kin So
Inventor： Ming-Hwa Liang , Stephane Shu Kin So
IPC: C12P19/34
CPC classification number: C12Q1/6895 , C12Q2600/156
Abstract: Methods for distinguishing between cotton species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the species of cotton utilized in the textile or cotton material of interest.
Abstract translation: 公开了通过从原棉材料或纺织品分析成熟棉纤维样品来区分棉花品种的方法。 从成熟的棉花纤维样品中提取DNA，并进行PCR技术，其能够鉴定在感兴趣的纺织品或棉花材料中使用的棉花种类。
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公开(公告)号：US08420400B2
公开(公告)日：2013-04-16
申请号：US11954055
申请日：2007-12-11
Applicant: James A. Hayward , Ming-Hwa Liang , Stephane Shu-Kin-So
Inventor： James A. Hayward , Ming-Hwa Liang , Stephane Shu-Kin-So
CPC classification number: C12Q1/6816 , C08K5/09 , C09D7/63 , C09D11/03 , Y10T436/14 , Y10T436/143333 , Y10T442/2508 , C12Q2563/185
Abstract: A method for authenticating and verifying a pharmaceutical item to be genuine is described. The method for authenticating a tablet comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to a tablet or capsule. The method also comprises collecting a sample of the tablet and verifying the tablet is genuine by detecting the particular nucleic acid material.
Abstract translation: 描述了用于认证和验证正品的药物的方法。 用于鉴定片剂的方法包括将与特定的核酸碱基序列相关联的特定核酸材料施用于片剂或胶囊。 该方法还包括收集片剂样品并通过检测特定的核酸材料来验证片剂是真实的。
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公开(公告)号：US08124333B2
公开(公告)日：2012-02-28
申请号：US11954009
申请日：2007-12-11
Applicant: Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
Inventor： Thomas Kwok , Ming-Hwa Liang , Stephane Shu Kin So
Abstract: A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particle generated by the methods of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.
Abstract translation: 描述了将发光报告基团与生物分子与核苷酸寡聚体连接的方法。 在将生物分子共价连接到光报告颗粒之前，光报告颗粒被甲硅烷基化和官能化以产生包被的光报告颗粒。 通过本发明方法产生的光报告颗粒可以通过诸如UV或IR光的光激发源激发，并且当生物分子是DNA时，通过诸如PCR的扩增技术检测所连接的DNA分子。
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