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    MOTORIZED SURGICAL INSTRUMENT
    11.
    发明申请
    MOTORIZED SURGICAL INSTRUMENT 审中-公开
    电动手术仪器

    公开(公告)号：US20160296219A1

    公开(公告)日：2016-10-13

    申请号：US15038478

    申请日：2014-11-21

    Applicant: Sudhir SRIVASTAVA

    Inventor： SUDHIR PREM SRIVASTAVA ,  SUGUMAR PERUMALSAMY ,  DAN WALLACE

    IPC: A61B17/00 ,  A61B34/00 ,  A61B34/30

    CPC classification number: A61B17/00234 ,  A61B17/29 ,  A61B34/30 ,  A61B34/71 ,  A61B2017/00398 ,  A61B2017/00477 ,  A61B2034/305 ,  A61B2034/715

    Abstract: In one embodiment of the invention, a motorized surgical instrument including an elongated shaft, a wrist member and a pair of working members with at least one working member moveable relative to other working member between open and closed position, is presented. The elongate shaft includes towards its proximal end a carriage plate that enables independent and controlled motion of the surgical instrument employing plurality of actuators securely held therein. Further, disclosed is a surgical instrument enabling easy and quick replacement of working members.

    Abstract translation: 在本发明的一个实施例中，提供一种电动手术器械，其包括细长轴，腕部构件和一对工作构件，其中至少一个工作构件相对于打开和关闭位置之间的其它工作构件可移动。 细长轴包括朝向其近端的托架板，该托架板使得能够独立且受控制地运动使用安全地保持在其中的多个致动器的外科器械。 此外，公开了能够容易且快速地更换工作构件的手术器械。

    Substituted benzimidazoles and their use for inducing apoptosis
    12.
    发明授权
    Substituted benzimidazoles and their use for inducing apoptosis 有权
    取代的苯并咪唑及其诱导凋亡的用途

    公开(公告)号：US07951957B2

    公开(公告)日：2011-05-31

    申请号：US12173869

    申请日：2008-07-16

    Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

    Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

    IPC: A61K31/4184 ,  C07D403/04

    CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04

    Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

    Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为键，羰基，羰基衍生物，亚乙基或亚乙基羰基，R 1为任选取代的氨基或羟基，以及 取代基R 2至R 6具有本说明书中给出的含义，这些化合物的合成方法，含有式（I）化合物的药物组合物，中间体，使用式（I）化合物作为药物，和 用于制备用于治疗肿瘤和自身免疫疾病的药物组合物，以及使用这样的式（I）化合物或含有其的药物组合物治疗肿瘤和自身免疫性疾病的方法。

    Furazanobenzimidazoles
    14.
    再颁专利
    Furazanobenzimidazoles 有权
    呋喃并苯并咪唑

    公开(公告)号：USRE42890E1

    公开(公告)日：2011-11-01

    申请号：US12796135

    申请日：2004-05-19

    Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

    Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

    IPC: A61K31/4245 ,  C07D413/04

    CPC classification number: C07D413/04 ,  C07D413/14

    Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R1 to R6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

    Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为氧，羰基，羰基肟衍生物或α，β-不饱和羰基，取代基R 1至R 6具有 本说明书中用作药物的含义，式（I）的新型化合物，合成这些化合物的方法，含有式（I）化合物的药物组合物，使用式（I）化合物 ）用于制备用于治疗肿瘤和自身免疫疾病的药物组合物，以及使用这样的式（I）化合物或含有其的药物组合物治疗肿瘤和自身免疫性疾病的方法

    Substituted benzimidazoles and their use for inducing apoptosis
    15.
    发明授权
    Substituted benzimidazoles and their use for inducing apoptosis 有权
    取代的苯并咪唑及其诱导凋亡的用途

    公开(公告)号：US07423157B2

    公开(公告)日：2008-09-09

    申请号：US11501648

    申请日：2006-08-09

    Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

    Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

    IPC: C07D403/04

    CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04

    Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

    Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为键，羰基，羰基，亚乙基或亚乙基羰基的衍生物，R 1， 任选取代的氨基或羟基，并且取代基R 2至R 6具有本说明书中给出的含义，这些化合物的合成方法，含有化合物的药物组合物 的式（I）化合物的中间体，用于将式（I）化合物用作药物并用于制备用于治疗肿瘤和自身免疫性疾病的药物组合物的用途，以及治疗肿瘤和自身免疫性疾病的方法 使用式（I）化合物或含有其的药物组合物。

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