公开(公告)号：US07959954B2

公开(公告)日：2011-06-14

申请号：US11519327

申请日：2006-09-11

Applicant: Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Kumar Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Kumar Rastogi ,  Mahendra Nath Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Kumar Tripathi ,  Sudhir Srivastava

Inventor： Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Kumar Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Kumar Rastogi ,  Mahendra Nath Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Kumar Tripathi ,  Sudhir Srivastava

IPC: A61K36/00 ,  A61K38/00

CPC classification number: A61K36/58 ,  C07D493/18

Abstract: A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus. Isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.

Abstract translation: 从Xylocarpus得到的可用于治疗糖尿病和血脂异常的生物活性成分。 该级分可以提供在可用作抗糖尿病和抗脂肪代谢剂的药物组合物中，或可用于治疗受试者的糖尿病和血脂异常的方法。 另外，从Xylocarpus制备生物活性成分的方法。 异构体的含氯木酚和这些化合物的制备。 此外，药物组合物包含治疗有效量的这种异构的木糖蛋白，任选地与一种或多种药学上可接受的载体，添加剂，润滑剂和稀释剂一起使用，以及这些药物组合物在治疗血脂异常的方法中的用途。

公开(公告)号：US07404962B1

公开(公告)日：2008-07-29

申请号：US10296215

申请日：2000-08-30

Applicant: Francis Joseph Pinto ,  Swati Ajay Piramal ,  Ram Pratap ,  Amiya Prasad Bhaduri ,  Harsh Pati Thapliyal ,  Sunil Kumar Puri ,  Guru Prasad Dutta ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Srivastava ,  Vikash Chandra Pandey ,  Sudhir Srivastava ,  Shio Kumar Singh ,  Ram Chandra Gupta ,  Jagdishwar Sahai Srivastava ,  Omkar Prasad Asthana

Inventor： Francis Joseph Pinto ,  Swati Ajay Piramal ,  Ram Pratap ,  Amiya Prasad Bhaduri ,  Harsh Pati Thapliyal ,  Sunil Kumar Puri ,  Guru Prasad Dutta ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Srivastava ,  Vikash Chandra Pandey ,  Sudhir Srivastava ,  Shio Kumar Singh ,  Ram Chandra Gupta ,  Jagdishwar Sahai Srivastava ,  Omkar Prasad Asthana

IPC: A61K39/015 ,  C07D215/38

CPC classification number: A61K31/4706 ,  A61K31/47 ,  Y02A50/411 ,  A61K2300/00

Abstract: A combination kit for the treatment of malaria caused by Plasmodium vivax (P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

Abstract translation: 用于治疗由间日疟原虫（间日疟原虫）引起的疟疾的组合试剂盒，其具有单个剂量的抗疟剂，3- [1 - [[4 - [（6-甲氧基-8-喹啉基）氨基]戊基] 氨基]亚乙基] - 二氢-2（3H） - 呋喃酮（I） 单剂量的抗疟剂，片剂形式的氯喹; 以及两种抗疟药物的管理指导材料。 组合试剂盒特别适用于6天的治疗方案，其中使用含有500mg磷酸氯喹（相当于300mg碱）的五片，第三天服用三次，第二天和第三次服用一次; 和5粒含有25mg 3- [1 - [[4 - [（6-甲氧基-8-喹啉基）氨基]戊基]氨基]亚乙基] - 二氢-2（3H） - 呋喃酮（I）的胶囊， 在二至六天内服用。

公开(公告)号：US07385061B2

公开(公告)日：2008-06-10

申请号：US10557539

申请日：2004-05-19

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

IPC: A61K31/4245 ,  C07D413/04

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R1 to R6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为氧，羰基，羰基的肟衍生物或α，β-不饱和羰基，取代基R 1 R 6具有本说明书中给出的用作药物的含义，式（I）的新型化合物，合成这些化合物的方法，包含含有化合物 式（I）化合物与式（I）化合物在制备用于治疗肿瘤和自身免疫性疾病的药物组合物中的用途，以及使用式（I）化合物治疗肿瘤和自身免疫性疾病的方法， 或含有其的药物组合物

公开(公告)号：US20070167505A1

公开(公告)日：2007-07-19

申请号：US10587675

申请日：2005-02-10

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

IPC: A61K31/4196 ,  A61K31/4184 ,  C07D403/02

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

公开(公告)号：US20070066670A1

公开(公告)日：2007-03-22

申请号：US11501648

申请日：2006-08-09

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

IPC: A61K31/4196 ,  A61K31/4184 ,  C07D403/02

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为键，羰基，羰基，亚乙基或亚乙基羰基的衍生物，R 1， 任选取代的氨基或羟基，并且取代基R 2至R 6具有本说明书中给出的含义，这些化合物的合成方法，含有化合物的药物组合物 的式（I）化合物的中间体，用于将式（I）化合物用作药物并用于制备用于治疗肿瘤和自身免疫性疾病的药物组合物的用途，以及治疗肿瘤和自身免疫疾病的方法 使用式（I）化合物或含有其的药物组合物。

公开(公告)号：US06896901B2

公开(公告)日：2005-05-24

申请号：US09742424

申请日：2000-12-22

Applicant: Ram Pratap ,  Raghwendra Pal ,  Satyawan Singh ,  Girja Shankar ,  Chandeshwar Nath ,  Hemant Kumar Singh ,  Depak Raina ,  Arwind Kumar Srivastava ,  Anil Kumar Rastogi ,  Puvvada Sri Ramachandra Murthy ,  Sudhir Srivastava ,  Onkar Prasad Asthana ,  Narenda Singh ,  Nitya Nand

Inventor： Ram Pratap ,  Raghwendra Pal ,  Satyawan Singh ,  Girja Shankar ,  Chandeshwar Nath ,  Hemant Kumar Singh ,  Depak Raina ,  Arwind Kumar Srivastava ,  Anil Kumar Rastogi ,  Puvvada Sri Ramachandra Murthy ,  Sudhir Srivastava ,  Onkar Prasad Asthana ,  Narenda Singh ,  Nitya Nand

IPC: A61K9/06 ,  A61K9/14 ,  A61K9/19 ,  A61K9/20 ,  A61K9/48 ,  A61K31/575 ,  A61K31/7024 ,  A61K36/00 ,  A61K36/18 ,  A61K36/328 ,  A61K47/04 ,  A61K47/12 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P3/00 ,  A61P3/10 ,  A61P17/00 ,  A61P17/04 ,  A61P17/06 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/10 ,  A61P37/08 ,  A61K35/78

CPC classification number: A61K36/328 ,  A61K31/575

Abstract: The present invention provides new uses of Gugulipid, an ethyl acetate extract of the resin of the plant Comiphora wighitii, for controlling or preventing cognitive dysfunction, hyperglycemia and some infective conditions of the skin and a method of preparing Gugulipid by agitating the resin in shake flask assembly or sonicating assembly and preparing a solid or a creamy dosage forms.

Abstract translation: 本发明提供了Gogulipid（一种用于控制或预防认知功能障碍，高血糖症和一些皮肤感染病症）的树脂的乙酸乙酯提取物的新用途，以及通过搅拌摇瓶中的树脂制备Gugilipid的方法 组装或超声处理组件，并制备固体或乳膏剂型。

公开(公告)号：US08486996B2

公开(公告)日：2013-07-16

申请号：US11433511

申请日：2006-05-12

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Goutam Saha ,  Subir Kumar Sadhukhan ,  Rohit Saxena ,  Sudhir Srivastava

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Goutam Saha ,  Subir Kumar Sadhukhan ,  Rohit Saxena ,  Sudhir Srivastava

IPC: A61K31/34 ,  C07D307/87

CPC classification number: C07D213/85

Abstract: The invention relates to novel substituted 2-(phenyl-, pyridyl- or pyrimidyl-carbonyl)-furanes and -thiophenes and related phenoxy/phenylthio-acetophenones and corresponding heterocyclic compounds, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such a diseases.

Abstract translation: 本发明涉及新的取代的2-（苯基 - ，吡啶基或嘧啶基 - 羰基） - 呋喃和 - 噻吩和相关的苯氧基/苯硫基 - 苯乙酮及其相应的杂环化合物，其制备方法，含有它们的药物组合物，其用途 任选地与一种或多种用于治疗肿瘤性疾病和自身免疫疾病的其它药学活性化合物组合，以及治疗这种疾病的方法。

公开(公告)号：US20080287681A1

公开(公告)日：2008-11-20

申请号：US12173869

申请日：2008-07-16

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutam Saha

IPC: C07D401/14 ,  C07D249/14 ,  C07D231/38

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为键，羰基，羰基，亚乙基或亚乙基羰基的衍生物，R 1， 任选取代的氨基或羟基，并且取代基R 2至R 6具有本说明书中给出的含义，这些化合物的合成方法，含有化合物的药物组合物 的式（I）化合物的中间体，用于将式（I）化合物用作药物并用于制备用于治疗肿瘤和自身免疫性疾病的药物组合物的用途，以及治疗肿瘤和自身免疫性疾病的方法 使用式（I）化合物或含有其的药物组合物。

公开(公告)号：US20070043061A1

公开(公告)日：2007-02-22

申请号：US10557539

申请日：2004-05-19

Applicant: Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutham Saha

Inventor： Martin Eberle ,  Felix Bachmann ,  Alessandro Strebel ,  Subho Roy ,  Sudhir Srivastava ,  Goutham Saha

IPC: A61K31/506 ,  A61K31/4439 ,  A61K31/4245 ,  C07D413/14

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R1 to R6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Abstract translation: 本发明涉及式（I）化合物，其中R表示芳基或杂芳基，X为氧，羰基，羰基的肟衍生物或α，β-不饱和羰基，取代基R 1 R 6具有本说明书中给出的用作药物的含义，式（I）的新型化合物，合成这些化合物的方法，包含含有化合物 式（I）化合物与式（I）化合物在制备用于治疗肿瘤和自身免疫性疾病的药物组合物中的用途，以及使用式（I）化合物治疗肿瘤和自身免疫性疾病的方法， 或含有其的药物组合物。

公开(公告)号：US06740639B1

公开(公告)日：2004-05-25

申请号：US09537088

申请日：2000-03-29

Applicant: Anil Kumar Dwivedi ,  Madhu Khanna ,  Wahajul Haq ,  Ram Raghubir ,  Sudhir Srivastava ,  Puvvada Sri Ramchandra Murthy ,  Onkar Prasad Asthana ,  Jagdishwar Sahay Srivastava ,  Satyawan Singh

Inventor： Anil Kumar Dwivedi ,  Madhu Khanna ,  Wahajul Haq ,  Ram Raghubir ,  Sudhir Srivastava ,  Puvvada Sri Ramchandra Murthy ,  Onkar Prasad Asthana ,  Jagdishwar Sahay Srivastava ,  Satyawan Singh

IPC: A61K3808

CPC classification number: B82Y5/00 ,  A61K9/2018 ,  A61K9/7023 ,  A61K38/08 ,  A61K47/6949

Abstract: The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin, pharmaceutical preparations containing these inclusion complexes of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin derivatives, the complexes being better soluble in water and having improved biopharmaceutical properties such as lesser toxicity, better analgesic action and non-addiction properties.

Abstract translation: 本发明提供L-赖氨酸-D-丙氨酰 - 甘氨酰-N-甲基苯丙氨酰 - 甘氨酰 - 异丙基酰胺与环糊精的高效阿片样物质的新型包合物，其含有L-酪氨酰-D-丙氨酰 - 甘氨酰-N - 甲基苯丙氨酰 - 甘氨酰 - 异丙基酰胺与环糊精衍生物，该配合物更好地溶于水，并具有改善的生物药物性质，例如毒性较小，更好的镇痛作用和非成瘾性质。