公开(公告)号：US07183291B2

公开(公告)日：2007-02-27

申请号：US09316313

申请日：1999-05-21

申请人： Ram Pratap ,  Amiya Prasad Bhaduri ,  Harsh Pati Thapliyal ,  Sunil Kumar Puri ,  Guru Prasad Dutta ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Srivastava ,  Vikash Chandra Pandey ,  Sudhir Srivastava ,  Shio Kumar Singh ,  Ram Chandra Gupta ,  Jagdishwar Sahai Srivastava ,  Omkar Prasad Asthana

发明人： Ram Pratap ,  Amiya Prasad Bhaduri ,  Harsh Pati Thapliyal ,  Sunil Kumar Puri ,  Guru Prasad Dutta ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Srivastava ,  Vikash Chandra Pandey ,  Sudhir Srivastava ,  Shio Kumar Singh ,  Ram Chandra Gupta ,  Jagdishwar Sahai Srivastava ,  Omkar Prasad Asthana

IPC分类号： C07D215/38 ,  A61K31/4709

CPC分类号： C07D405/12 ,  A61K31/4709 ,  Y02A50/411

摘要： The present invention a novel use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and controlling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

摘要翻译： 本发明提供了一种新颖的使用伯氨基衍生物N - （3-乙基吡啶四氢呋喃-2-酮）-N 4 - （6-甲氧基-8-喹啉基）-1 ，4-戊二胺治疗和控制疟疾传播。 特别地，本发明公开了一种通过使用伯氨基衍生物N 1 - （3-乙基吡啶四氢呋喃-2-酮）-N 4 - （ 6-甲氧基-8-喹啉基）-1,4-戊二胺作为杀丝菌剂。

公开(公告)号：US07404962B1

公开(公告)日：2008-07-29

申请号：US10296215

申请日：2000-08-30

申请人： Francis Joseph Pinto ,  Swati Ajay Piramal ,  Ram Pratap ,  Amiya Prasad Bhaduri ,  Harsh Pati Thapliyal ,  Sunil Kumar Puri ,  Guru Prasad Dutta ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Srivastava ,  Vikash Chandra Pandey ,  Sudhir Srivastava ,  Shio Kumar Singh ,  Ram Chandra Gupta ,  Jagdishwar Sahai Srivastava ,  Omkar Prasad Asthana

发明人： Francis Joseph Pinto ,  Swati Ajay Piramal ,  Ram Pratap ,  Amiya Prasad Bhaduri ,  Harsh Pati Thapliyal ,  Sunil Kumar Puri ,  Guru Prasad Dutta ,  Anil Kumar Dwivedi ,  Satyawan Singh ,  Pratima Srivastava ,  Vikash Chandra Pandey ,  Sudhir Srivastava ,  Shio Kumar Singh ,  Ram Chandra Gupta ,  Jagdishwar Sahai Srivastava ,  Omkar Prasad Asthana

IPC分类号： A61K39/015 ,  C07D215/38

CPC分类号： A61K31/4706 ,  A61K31/47 ,  Y02A50/411 ,  A61K2300/00

摘要： A combination kit for the treatment of malaria caused by Plasmodium vivax (P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

摘要翻译： 用于治疗由间日疟原虫（间日疟原虫）引起的疟疾的组合试剂盒，其具有单个剂量的抗疟剂，3- [1 - [[4 - [（6-甲氧基-8-喹啉基）氨基]戊基] 氨基]亚乙基] - 二氢-2（3H） - 呋喃酮（I） 单剂量的抗疟剂，片剂形式的氯喹; 以及两种抗疟药物的管理指导材料。 组合试剂盒特别适用于6天的治疗方案，其中使用含有500mg磷酸氯喹（相当于300mg碱）的五片，第三天服用三次，第二天和第三次服用一次; 和5粒含有25mg 3- [1 - [[4 - [（6-甲氧基-8-喹啉基）氨基]戊基]氨基]亚乙基] - 二氢-2（3H） - 呋喃酮（I）的胶囊， 在二至六天内服用。