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公开(公告)号：US20230017150A1
公开(公告)日：2023-01-19
申请号：US17812892
申请日：2022-07-15
Inventor： Deok Hee LEE , Seon Moon HWANG , Joon Ho CHOI
IPC: A61B17/12
Abstract: A hydrogel stent for cerebral aneurysm includes a hydrogel polymer, and a stent body wrapping at least a portion of the hydrogel polymer. The stent body is expandable in a cerebral aneurysm of a blood vessel. The stent body is provided in a mesh type surrounding at least a portion of the hydrogel polymers. An embolization device for cerebral aneurysm, includes a hydrogel stent for cerebral aneurysm; a micro-conduit providing a movement path for guiding the hydrogel stent to a cerebral aneurysm of a blood vessel; and a pusher wire connected to the hydrogel stent to be movable in the movement path.
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公开(公告)号：US11452794B2
公开(公告)日：2022-09-27
申请号：US15772213
申请日：2016-10-28
Applicant: CG BIO CO., LTD. , THE ASAN FOUNDATION
Inventor： Hee Jun Park , Hyun Seung Ryu , Joon Pio Hong , Jun Hyuk Seo , Jong Ha Park , Soon Gee Hong , Hak Su Jang , So Myoung Lee , Bo Young Yoo
Abstract: The present invention relates to a wound dressing material comprising a fibrillated acellular dermis matrix and a biodegradable polymer aqueous solution and, more specifically, to: a wound dressing material comprising 5-20 wt % of a fibrillated acellular dermis matrix, 0.5-5 wt % of a biodegradable polymer, and 75-94.5 wt % of water; and a preparation method therefor.
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13.发明授权公开(公告)号：US11439354B2
公开(公告)日：2022-09-13
申请号：US16483039
申请日：2018-02-05
Inventor： Chang Mo Hwang , Young Hak Kim , Gi Byoung Nam , Jae Soon Choi , Gi Seok Jeong
Abstract: The present invention is a system for three-dimensionally mapping a heart, comprising: a mapping catheter including three or more optical cores each of which has a plurality of FBGs disposed in the lengthwise direction of a catheter body, and a plurality of electrodes disposed in the lengthwise direction of the catheter body and exposed on the outer circumferential surface of the catheter body, wherein the electrodes make contact with the inner wall of the heart; and a mapping processor for calculating coordinates of the FBGs by wavelength information of reflected light received from the three or more optical cores, and calculating coordinates of the electrodes from the coordinates of the FBGs so as to build a three-dimensional shape of the heart by using a sample point at which the plurality of electrodes make contact.
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公开(公告)号：US20220252608A1
公开(公告)日：2022-08-11
申请号：US17621451
申请日：2020-06-22
Inventor： Sung SHIN
Abstract: The present invention relates to a biomarker for the non-invasive diagnosis of kidney transplantation rejection and use thereof, and particularly to: a biomarker composition and kit for diagnosing antibody-mediated rejection after kidney transplantation or predicting the prognosis of a patient after kidney transplantation, comprising any one or more proteins selected from the group consisting of LBP and CST3, or gene(s) encoding for the same; a method for providing information required for diagnosing antibody-mediated rejection after kidney transplantation or predicting the prognosis of a patient after kidney transplantation, by using the marker composition; a method for providing information required for determining a therapy for rejection after kidney transplantation; a method for the diagnosis and treatment of antibody-mediated rejection after kidney transplantation; and a method for screening for a therapeutic agent for antibody-mediated rejection after kidney transplantation.
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15.发明申请公开(公告)号：US20220178929A1
公开(公告)日：2022-06-09
申请号：US17441386
申请日：2020-03-23
Inventor： Kyung Jin LEE , Sin HWANG
IPC: G01N33/574 , G01N33/533 , C12N5/16 , C12P21/00 , C07K16/18
Abstract: Provided are the use of cereblon (CRBN) as a biomarker for diagnosis of hepatocellular carcinoma and novel monoclonal antibodies specific to CRBN. More specifically, provided are a composition and a kit for diagnosing or predicting the prognosis of hepatocellular carcinoma by using CRBN as a biomarker for diagnosis of hepatocellular carcinoma, an information providing method for diagnosing or predicting the prognosis of hepatocellular carcinoma, two novel monoclonal antibodies binding specifically to CRBN, and hybridoma cells producing the same. The expression level difference of CRBN protein allows patients with hepatocellular carcinoma to be diagnosed early and indicates better predictive capabilities than the presence or absence of microvascular invasion, which was an important factor in predicting a prognosis of hepatocellular carcinoma in prior art, and thus can be expected to be used as a diagnostic marker to diagnose hepatocellular carcinoma and to evaluate a prognosis after hepatic resection.
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Patent Agency Ranking
公开(公告)号：US20220089774A1
公开(公告)日：2022-03-24
申请号：US17310296
申请日：2020-01-29
Applicant: THE ASAN FOUNDATION , EDISBIOTECH CO., LTD. , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
Inventor： Seung-Jae MYUNG , Eun-Ju DO , Jayoung KANG , Hye-Nam SON , Hyori KIM , A-Neum LEE , Yeong Hui CHO
IPC: C07K16/32 , G01N33/574
Abstract: The present invention relates to a monoclonal antibody which specifically binds to an EGF2 domain of colon cancer secreted protein-2 (CCSP-2), or an antigen-binding fragment thereof. The monoclonal antibody or the antigen-binding fragment thereof of the present invention specifically binds to the EGF2 domain of CCSP-2, and thus has significantly increased affinity compared with existing peptides specifically binding to CCSP-2 and further increased specificity compared with existing antibodies to CCSP-2. Therefore, in future, accurate diagnosis can be achieved by specific detection of CCSP-2 in the protein level.
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公开(公告)号：US11185666B2
公开(公告)日：2021-11-30
申请号：US16530167
申请日：2019-08-02
Inventor： Jae Soon Choi , Young Jin Moon , Gi Byoung Nam , Young Hak Kim , Zhenkai Hu , Ho Yul Lee
IPC: A61M25/01
Abstract: A catheter delivery device having an improved mechanism for inserting a catheter into a blood vessel of a patient. The catheter delivery device includes at least: a body including a delivery path of a catheter; a pair of feeders having grippers located on the delivery path of the body and are configured to grip and release the catheter; and a rotator configured to rotate the catheter gripped by the feeders. The feeders move from a grip position where the grippers grip the catheter to a forward position where the grippers advance in a state of gripping the catheter, from the forward position to a grip release position where the grippers release the catheter, from the grip release position to a backward position where the grippers retract in a state of releasing a grip on the catheter, and from the backward position to the grip position.
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公开(公告)号：US20210220340A1
公开(公告)日：2021-07-22
申请号：US17254323
申请日：2019-06-21
Inventor： Jae-Young KOH , Ha Na KIM , Tae-Youn KIM , Huikyoung LEE
IPC: A61K31/436 , A61K31/506 , A61K31/404 , A61K31/05 , A61K31/4245 , A61K31/496 , A61K31/4025 , A61K31/505 , A61K31/428 , A61K31/426 , A61P25/28 , A61P39/06
Abstract: The present invention relates to a pharmaceutical composition for prevention or treatment of neurodegenerative disease, a composition employing amlexanox, which has been verified for safety through clinical trials. In addition, the present invention relates to a pharmaceutical composition for prevention or treatment of amyloid beta-caused cell damage, the composition employing a phosphodiesterase (PDE) inhibitor inclusive of amlexanox. The composition of the present invention can be advantageously and safely used for ameliorating or treating amyloid beta-caused neurodegenerative disease and cell damage, without worry about side effects.
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公开(公告)号：US11037336B2
公开(公告)日：2021-06-15
申请号：US16409541
申请日：2019-05-10
Applicant: Korea Advanced Institute of Science and Technology , The Asan Foundation , University of Ulsan Foundation For Industry Cooperation
Inventor： JongChul Ye , Eunhee Kang , Dong Hyun Yang , Joon Bum Seo , Hyun Jung Koo
Abstract: A method for processing an unmatched low-dose X-ray computed tomography (CT) image using a neural network and an apparatus therefor are provided. The method includes receiving a low-dose X-ray CT image and removing noise from the low-dose X-ray CT image using a unsupervised learning based neural network learned using unmatched data to reconstruct a routine-dose X-ray CT image corresponding to the low-dose X-ray CT image.
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公开(公告)号：US10758746B2
公开(公告)日：2020-09-01
申请号：US16015974
申请日：2018-06-22
Inventor： Jung Won Kwak , Sang Wook Lee , Byung Chul Cho , Seung Do Ahn , Won Sik Choi , Woo Sang Ahn , Chi Young Jeong , Seong Soo Shin , Kyoung Jun Yoon
Abstract: Disclosed are a radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, a radiotherapy system including the radiotherapy assistant apparatus, and method for the radiotherapy system. The radiotherapy assistant apparatus for modulating a build-up region of a photon beam for a radiotherapy, including at least: a magnetic field generator that generates a magnetic field that has a direction perpendicular to a movement direction of the photon beam, the magnetic field generator is disposed on a movement route along which the photon beam moves toward a target portion of the radiotherapy; and a magnetic field intensity adjuster that adjusts an intensity of the magnetic field generated by the magnetic field generator. The magnetic field generator disperses secondary electrons that have particular energy levels equal to or lower than a preset value.
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