公开(公告)号：US20240024256A1

公开(公告)日：2024-01-25

申请号：US18265525

申请日：2021-12-07

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Gregory M. Sullivan

IPC: A61K31/135 ,  A61P25/00 ,  A61K9/00

CPC classification number: A61K31/135 ,  A61P25/00 ,  A61K9/006

Abstract: Methods for treating fibromyalgia and one or more of its associated symptoms of pain, sleep disturbance and/or fatigue comprising administering to a subject in need thereof, 5.6 mg cyclobenzaprine HCl per day in one or more dosage units by transmucosal administration, the cyclobenzaprine HCl being in a form of a eutectic, and the one or more dosage units further comprising a basifying agent.

公开(公告)号：US20240009146A1

公开(公告)日：2024-01-11

申请号：US18037815

申请日：2021-11-19

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Greg M. Sullivan

IPC: A61K31/137

CPC classification number: A61K31/137

Abstract: The present disclosure provides a method for treating alcohol use disorder (AUD) and associated symptoms to a subject in need thereof by administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The pharmaceutically acceptable salt comprises a cyclobenzaprine acid salt.

公开(公告)号：US20190185438A1

公开(公告)日：2019-06-20

申请号：US15833973

申请日：2017-12-06

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Bruce Daughtery

IPC: C07D265/30 ,  C07C57/15

CPC classification number: C07D265/30 ,  A61K31/5375 ,  C07B2200/13 ,  C07C57/15

Abstract: Disclosed herein are salts and polylmoprhs of (2S)-2-[(S)-(ethoxyphenoxy)phenylmethyl]morpholine (esreboxetine) as shown in Formula I: wherein an acid is selected from adipic, L-ascorbic, L-aspartic, fumaric, glycolic, hydrochloric, maleic, mucic, phosphoric, sulfuric, and thiocyanic acid.

公开(公告)号：US20230414536A1

公开(公告)日：2023-12-28

申请号：US18212500

申请日：2023-06-21

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman

IPC: A61K31/137 ,  A61P29/00 ,  A61P31/14 ,  A61K47/26

CPC classification number: A61K31/137 ,  A61P29/00 ,  A61P31/14 ,  A61K47/26

Abstract: The present disclosure provides methods for treating Post-Acute Sequelae of Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection (PASC) or one or more symptoms associated with said PASC, comprising administering to a subject in need or at risk thereof a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

公开(公告)号：US20230149348A1

公开(公告)日：2023-05-18

申请号：US18075386

申请日：2022-12-05

Applicant: TONIX PHARMACEUTICALS HOLDING CORP

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  A61K31/135 ,  A61K45/06 ,  C07C211/32 ,  C07D205/04

CPC classification number: A61K31/397 ,  A61K31/135 ,  A61K45/06 ,  C07C211/32 ,  C07D205/04

Abstract: The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US20220016268A1

公开(公告)日：2022-01-20

申请号：US17378642

申请日：2021-07-16

Applicant: TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMA LIMITED

Inventor： Seth Lederman ,  Siobhan J. Fogarty

IPC: A61K49/00 ,  C07K14/005

Abstract: The present disclosure provides methods for detecting cell-mediated immunity to SARS-CoV-2 in a subject, methods for detecting a cell-mediated immune response against SARS-CoV-2 in a subject and methods for determining if a vaccine against SARS-CoV-2 elicits a cell-mediated immune response in a subject, comprising administering to the skin of the subject one or more peptides.

公开(公告)号：US20210315841A1

公开(公告)日：2021-10-14

申请号：US17226058

申请日：2021-04-08

Applicant: TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMACEUTICALS, INC.

Inventor： Megan Elizabeth Parmenter ,  Gregory M. Sullivan

IPC: A61K31/135 ,  A61K45/06 ,  A61K33/00 ,  A61K31/085 ,  A61K31/496 ,  A61K31/485 ,  A61K31/568 ,  A61K31/519 ,  A61K31/137 ,  A61K31/5513 ,  A61K31/15 ,  A61K31/138 ,  A61K9/20 ,  A61P15/00

Abstract: The present disclosure provides a pharmaceutical composition comprising therapeutically effective amounts of cyclobenzaprine and one or more agents, and methods of treating and/or preventing sexual dysfunction.

公开(公告)号：US20200230104A1

公开(公告)日：2020-07-23

申请号：US16630832

申请日：2018-07-13

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  C07C211/32 ,  C07D205/04 ,  A61K45/06 ,  A61K31/135

Abstract: The present invention relates to cyclobenzaprine analogs useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US12156864B2

公开(公告)日：2024-12-03

申请号：US18075386

申请日：2022-12-05

Applicant: TONIX PHARMACEUTICALS HOLDING CORP

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  A61K31/135 ,  A61K45/06 ,  C07C211/32 ,  C07D205/04

Abstract: The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US20240301004A1

公开(公告)日：2024-09-12

申请号：US18621985

申请日：2024-03-29

Applicant: TONIX PHARMACEUTICALS HOLDING CORP. ,  AARHUS UNIVERSITY

Inventor： Steen Jakobsen ,  Michael Winterdahl ,  Erik Nguyen Nielsen ,  David C. Yeomans ,  Dean Carson

IPC: C07K7/16 ,  A61K51/08 ,  G01N33/60

CPC classification number: C07K7/16 ,  A61K51/084 ,  G01N33/60

Abstract: Disclosed are 13N-oxytocin molecules, methods of manufacture of 13N-oxytocin molecules and methods of use of 13N-oxytocin molecules in the determination of the distribution and kinetics of 13N-oxytocin molecules after craniofacial or other application methods.