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    Targeted bifunctional molecules and therapies based thereon
    11.
    发明授权
    Targeted bifunctional molecules and therapies based thereon 有权
    基于目标的双功能分子和治疗方法

    公开(公告)号：US07498025B1

    公开(公告)日：2009-03-03

    申请号：US09716842

    申请日：2000-11-17

    申请人： Roger Briesewitz ,  Gerald R. Crabtree ,  Thomas J. Wandless

    发明人： Roger Briesewitz ,  Gerald R. Crabtree ,  Thomas J. Wandless

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K5/10 ,  C07K5/00 ,  C12N9/90

    CPC分类号： A61K31/00

    摘要： Targeted bifunctional molecules and methods for their use are provided. The subject targeted bifunctional molecules are conjugates of a drug moiety and a targeting moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules are further characterized in that they exhibit a modulated biodistribution upon administration to a host as compared to a free drug control. The subject targeted bifunctional molecules find use in a variety of therapeutic applications.

    摘要翻译： 提供了靶向的双功能分子及其使用方法。 主题靶向双功能分子是药物部分和靶向部分的缀合物，其中这两个部分任选地通过连接基团连接。 双功能分子的进一步特征在于，与游离药物对照相比，它们在施用于宿主时表现出调节的生物分布。 主题靶向双功能分子可用于各种治疗应用。

    Bifunctional molecules and their use in the disruption of protein-protein interactions
    17.
    发明授权
    Bifunctional molecules and their use in the disruption of protein-protein interactions 有权
    双功能分子及其在蛋白质 - 蛋白质相互作用破坏中的应用

    公开(公告)号：US07220552B1

    公开(公告)日：2007-05-22

    申请号：US09716054

    申请日：2000-11-17

    申请人： Gerald R. Crabtree ,  Kryn Stankunas ,  Roger Briesewitz ,  Thomas J. Wandless

    发明人： Gerald R. Crabtree ,  Kryn Stankunas ,  Roger Briesewitz ,  Thomas J. Wandless

    IPC分类号： G01N33/53 ,  A61K39/00

    CPC分类号： G01N33/6845 ,  G01N33/542

    摘要： Bifunctional inhibitor molecules and methods for their use in the inhibition of protein—protein interactions are provided. The subject bifunctional inhibitor molecules are conjugates of a target protein ligand and a blocking protein ligand, where these two moieties are optionally joined by a linking group. In the subject methods, an effective amount of the bifunctional inhibitor molecule is administered to a host in which the inhibition of a protein—protein interaction is desired. The bifunctional inhibitor molecule simultaneously binds to its corresponding target and blocking proteins to produce a tripartite complex that inhibits the target protein—protein interaction. The subject methods and compositions find use in a variety of applications, including therapeutic applications.

    摘要翻译： 提供了双功能抑制剂分子及其用于抑制蛋白质 - 蛋白质相互作用的方法。 受试者双功能抑制剂分子是靶蛋白配体和阻断蛋白配体的缀合物，其中这两个部分任选地通过连接基团连接。 在本方法中，将有效量的双功能抑制剂分子施用于需要抑制蛋白质 - 蛋白质相互作用的宿主。 双功能抑制剂分子同时结合其相应的靶标和阻断蛋白质以产生抑制靶蛋白 - 蛋白质相互作用的三方复合物。 主题方法和组合物可用于各种应用，包括治疗应用。