公开(公告)号：US06626857B1

公开(公告)日：2003-09-30

申请号：US09856135

申请日：2001-07-23

申请人： Tomio Ohta ,  Tetsuya Miyatake ,  Yoshihiko Kinoshita ,  Tomoya Murakami

发明人： Tomio Ohta ,  Tetsuya Miyatake ,  Yoshihiko Kinoshita ,  Tomoya Murakami

IPC分类号： A61M3700

CPC分类号： A61M1/3455 ,  A61M1/3441 ,  A61M1/3458 ,  A61M1/369 ,  A61M2230/207

摘要： An extracorporeal circulation apparatus used for the selective temperature controlling method in which a temperature of an object is kept at a predetermined temperature, includes: (A) a fluid replacement supply unit which quantitatively supplies a fluid replacement of which temperature has been adjusted into a blood vessel; (B) a blood concentration unit which quantitatively withdraws blood diluted by the fluid replacement from a blood vessel and concentrates the withdrawn diluted blood; and (C) a blood supply unit which controls a temperature of the blood which has been concentrated and quantitatively supplies the concentrated blood into a blood vessel, the blood concentration unit comprising a diluted blood temperature sensor which measures a temperature of the withdrawn diluted blood, and the fluid replacement supply unit including a means which controls a temperature of the fluid replacement to be supplied based on a different extent between the measured diluted blood temperature and the predetermined temperature of the object.

摘要翻译： 一种用于选择温度控制方法的体外循环装置，其中物体的温度保持在预定温度，包括：（A）液体替换供应单元，其将已经调节了温度的液体置换定量为血液 容器;（B）血液浓度单元，其定量地从血管中取出由液体替换物稀释的血液，并浓缩取出的稀释血液; 和（C）血液供给单元，其对已经浓缩并定量地将浓缩血液供给到血管中的血液的温度进行控制，所述血液浓度单元包括测定取出的稀释血液的温度的稀释型血液温度传感器， 并且所述流体置换供给单元包括基于所测量的稀释血液温度和所述物体的预定温度之间的不同程度控制要供应的所述流体置换的温度的装置。

公开(公告)号：US4737506A

公开(公告)日：1988-04-12

申请号：US851134

申请日：1986-04-07

申请人： Noboru Shimizu ,  Hiroyuki Ishiwata ,  Tomio Ohta ,  Hiroshi Ishihama ,  Yasumi Uchida

发明人： Noboru Shimizu ,  Hiroyuki Ishiwata ,  Tomio Ohta ,  Hiroshi Ishihama ,  Yasumi Uchida

IPC分类号： C07D401/12 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/455 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/90 ,  C07D401/14

CPC分类号： C07D211/90

摘要： This invention relates to a 1,4-dihydropyridine-3,5-dicarboxylate derivative represented by the following general formula (I): ##STR1## wherein R means an imidazolyl or pyridyl group, R.sub.1 denotes a hydrogen or halogen atom or a nitro or trifluoromethyl group, R.sub.2 is a lower alkyl group, X is CH or N, A means a lower alkylene group, ##STR2## B being a lower alkylene or O-lower alkylene group, ##STR3## R.sub.4 being a hydrogen atom or lower alkyl group, or ##STR4## m denotes a number of 1-3, and n stands for 1 or 2. The derivative has vasodilative effects, hyperkinemic effects, platelet aggregation inhibitory effects, thromboxane A.sub.2 formation inhibitory effects and so on, and are hence useful as a pharmaceutical product such as vasodilator, antihypertensive, antithrombotic agent, antiarteriosclerotic agent or the like.

摘要翻译： PCT No.PCT / JP85 / 00449 Sec。 一九八六年四月七日 102（e）日期1986年4月7日PCT提交1985年8月12日PCT公布。 公开号WO86 / 01206 PCT 日本特愿1986年2月27日。本发明涉及由以下通式（I）表示的1,4-二氢吡啶-3,5-二羧酸酯衍生物：其中R表示咪唑基或吡啶基，R1 表示氢或卤素原子或硝基或三氟甲基，R 2为低级烷基，X为CH或N，A表示低级亚烷基，B为低级亚烷基或O-低级亚烷基，IMA图 > R4是氢原子或低级烷基，或者表示1-3个数，n代表1或2.该衍生物具有血管扩张作用，超动力作用，血小板聚集抑制作用，血栓素A2形成抑制 效果等，因此可用作药物产品如血管扩张剂，抗高血压剂，抗血栓形成剂，抗动脉硬化剂等。