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    AUTOIMMUNE MECHANICAL IMMUNOMODULATION
    2.
    发明公开
    AUTOIMMUNE MECHANICAL IMMUNOMODULATION 审中-公开

    公开(公告)号：US20230226263A1

    公开(公告)日：2023-07-20

    申请号：US18051004

    申请日：2022-10-30

    申请人： AMINA Sciences LLC

    发明人： Nashwa A. Khalil

    IPC分类号： A61M1/34 ,  A61M1/36 ,  A61K35/14

    CPC分类号： A61M1/3496 ,  A61M1/3455 ,  A61M1/3693 ,  A61K35/14 ,  A61M2205/127 ,  A61M2202/0478 ,  A61M2206/10 ,  A61M2230/04 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/054 ,  A61M2205/10 ,  A61M2205/36 ,  A61M2205/3331 ,  A61M2205/366

    摘要： The present disclosure describes a novel therapeutic apheresis system and, more specifically, methods and an apparatus for performing therapeutic apheresis. The present disclosure provides highly efficient methods for therapeutic apheresis that modulate the immune system, thereby resulting in treatment of one or more underlying immunological disease processes. In some embodiments, the disclosed methods return at least a portion of blood from an extracorporeal circuit to a patient in pulsatile flow, where the portion of blood that is returned is augmented. In other embodiments, the disclosed methods and apparatus use the central arterial system to exchange volumes of plasma to immunomodulate disease processes. The disclosed methods combine concepts of intermittent flow and continuous flow therapeutic apheresis with established cardiovascular concepts. In addition, the disclosed methods reduce the amount of time spent by patients in therapeutic apheresis sessions and decrease patients' dependence on immunological drugs that may have detrimental adverse effects.

    DIALYSATE-EXTRACTING APPARATUS
    4.
    发明申请
    DIALYSATE-EXTRACTING APPARATUS 审中-公开

    公开(公告)号：US20180071445A1

    公开(公告)日：2018-03-15

    申请号：US15812507

    申请日：2017-11-14

    申请人： Nikkiso Company Limited

    发明人： Hiroaki Suzuki

    IPC分类号： A61M1/16 ,  A61M1/36 ,  A61M39/16

    CPC分类号： A61M1/168 ,  A61M1/16 ,  A61M1/1621 ,  A61M1/1656 ,  A61M1/3455 ,  A61M1/3643 ,  A61M39/16 ,  A61M2039/167 ,  B01D35/147

    摘要： A dialysate-extracting apparatus in which a collecting port can be disinfected with no disinfecting work to be performed by a worker. A dialysate-extracting apparatus includes a dialysate-extracting device having an introduction port and a discharge port each of which is connected to the flow route for liquid and allows the liquid to flow therethrough, and a collecting port from which the liquid flowing in the flow route is collectable; and an opening-and-closing device that is movable between a closing position where the opening-and-closing device covers the collecting port of the dialysate-extracting device and an opening position where the opening-and-closing device 6 opens the collecting port. The dialysate-extracting apparatus further includes an ultraviolet-applying device attached to the opening-and-closing device and that is capable of applying ultraviolet rays to the collecting port when the opening-and-closing device is at the closing position.

    CITRATE DETECTOR FOR BLOOD PROCESSING SYSTEM
    7.
    发明申请
    CITRATE DETECTOR FOR BLOOD PROCESSING SYSTEM 有权
    用于血液加工系统的CITRATE检测器

    公开(公告)号：US20140132945A1

    公开(公告)日：2014-05-15

    申请号：US13752457

    申请日：2013-01-29

    申请人： FENWAL, INC.

    发明人： Craig Sandford

    IPC分类号： G01N33/49

    CPC分类号： G01N21/17 ,  A61M1/0209 ,  A61M1/16 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3455 ,  A61M1/3621 ,  A61M1/367 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M5/00 ,  A61M2205/18 ,  A61M2205/3306 ,  A61M2205/3313 ,  G01N33/49

    摘要： A citrate detector is provided for use in combination with a blood processing system and replacement fluid tubing or conduit of a disposable set. The citrate detector comprises a light source and a light detector. The light source is configured to emit a light having a wavelength absorbed by citrate, but at least partially transmitted by the replacement fluid conduit of the disposable set. The light detector is configured to receive at least a portion of the light from the light source and generate a signal indicative of the presence or absence of citrate in the replacement fluid conduit based, at least in part, on the amount of light received from the light source. A blood processing system incorporating such a citrate detector may include a flow detector for determining whether fluid is present in the conduit prior to checking for the presence of citrate.

    摘要翻译： 柠檬酸盐检测器被提供用于与血液处理系统和替换流体管道或一次性套管的管道组合使用。 柠檬酸盐检测器包括光源和光检测器。 光源被配置为发射具有被柠檬酸盐吸收的波长的光，但是至少部分地由一次性组合的替换流体导管传播。 光检测器被配置为从光源接收至少一部分光，并且至少部分地基于从所述光源接收到的光的量而产生指示所述替换流体导管中存在或不存在柠檬酸盐的信号 光源。 结合这样的柠檬酸盐检测器的血液处理系统可以包括用于在检查柠檬酸盐的存在之前确定流体是否存在于导管中的流量检测器。

    BLOOD PURIFICATION SYSTEM
    8.
    发明申请
    BLOOD PURIFICATION SYSTEM 有权
    血液净化系统

    公开(公告)号：US20100087771A1

    公开(公告)日：2010-04-08

    申请号：US12527270

    申请日：2008-02-14

    申请人： Atsushi Karakama ,  Soichiro Okazaki

    发明人： Atsushi Karakama ,  Soichiro Okazaki

    IPC分类号： A61M1/14

    CPC分类号： A61M1/34 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1643 ,  A61M1/3431 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/3455 ,  A61M2205/12 ,  A61M2205/3334 ,  A61M2205/3393

    摘要： Provision of a blood purification system comprising a blood purification tubing and a blood purification apparatus particularly suitable for use in continuous hemofiltration in which in the treatment of a patient with renal disease, multiple organ failure, and the like, the amount of water removed from the patient and the amount of supply to the patient can be more accurately controlled, and in which preparation operation is easy. A blood purification system comprising a blood purification tubing and a blood purification apparatus wherein the soft tubes of flow paths connecting a first planar panel and a second planar panel, and the location of the soft tubes are selected to satisfy a formula of a predetermined condition.

    摘要翻译： 提供血液净化系统，其包括血液净化管和特别适合用于连续血液滤过的血液净化装置，其中在治疗患有肾脏疾病，多器官功能衰竭等的患者中，从 可以更准确地控制患者的供给量，并且准备操作容易。 一种血液净化系统，其包括血液净化管和血液净化装置，其中选择连接第一平面面板和第二平面面板的流路的软管和软管的位置以满足预定条件的公式。

    Extracorporeal circulation device and method for isolation temperature control method
    10.
    发明授权
    Extracorporeal circulation device and method for isolation temperature control method 有权
    体外循环装置及隔离温度控制方法

    公开(公告)号：US06626857B1

    公开(公告)日：2003-09-30

    申请号：US09856135

    申请日：2001-07-23

    申请人： Tomio Ohta ,  Tetsuya Miyatake ,  Yoshihiko Kinoshita ,  Tomoya Murakami

    发明人： Tomio Ohta ,  Tetsuya Miyatake ,  Yoshihiko Kinoshita ,  Tomoya Murakami

    IPC分类号： A61M3700

    CPC分类号： A61M1/3455 ,  A61M1/3441 ,  A61M1/3458 ,  A61M1/369 ,  A61M2230/207

    摘要： An extracorporeal circulation apparatus used for the selective temperature controlling method in which a temperature of an object is kept at a predetermined temperature, includes: (A) a fluid replacement supply unit which quantitatively supplies a fluid replacement of which temperature has been adjusted into a blood vessel; (B) a blood concentration unit which quantitatively withdraws blood diluted by the fluid replacement from a blood vessel and concentrates the withdrawn diluted blood; and (C) a blood supply unit which controls a temperature of the blood which has been concentrated and quantitatively supplies the concentrated blood into a blood vessel, the blood concentration unit comprising a diluted blood temperature sensor which measures a temperature of the withdrawn diluted blood, and the fluid replacement supply unit including a means which controls a temperature of the fluid replacement to be supplied based on a different extent between the measured diluted blood temperature and the predetermined temperature of the object.

    摘要翻译： 一种用于选择温度控制方法的体外循环装置，其中物体的温度保持在预定温度，包括：（A）液体替换供应单元，其将已经调节了温度的液体置换定量为血液 容器;（B）血液浓度单元，其定量地从血管中取出由液体替换物稀释的血液，并浓缩取出的稀释血液; 和（C）血液供给单元，其对已经浓缩并定量地将浓缩血液供给到血管中的血液的温度进行控制，所述血液浓度单元包括测定取出的稀释血液的温度的稀释型血液温度传感器， 并且所述流体置换供给单元包括基于所测量的稀释血液温度和所述物体的预定温度之间的不同程度控制要供应的所述流体置换的温度的装置。