公开(公告)号：US20120004197A1

公开(公告)日：2012-01-05

申请号：US13256549

申请日：2010-03-31

Applicant: Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Takahiro Kitamura ,  Syunji Takemura ,  Gen Watanabe ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

Inventor： Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Takahiro Kitamura ,  Syunji Takemura ,  Gen Watanabe ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

IPC: A61K31/4706 ,  C07D413/12 ,  C07D215/14 ,  C07D215/233 ,  C07D401/12 ,  A61P7/06 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/47 ,  A61K31/496 ,  A61K31/69 ,  C07D215/44 ,  C07F5/02

CPC classification number: C07D215/42 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/69 ,  C07D215/233 ,  C07D215/44 ,  C07D215/46 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11, a sulfur atom, or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; B represents a C6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

Abstract translation: 公开了具有低分子量且具有增强EPO产生活性和/或提高血红蛋白生成活性的化合物。 具体公开的是EPO生产增强剂和/或包含1-酰基-4-（取代的氧基，取代的氨基或取代的硫代）-1,2,3,4-四氢喹啉衍生物，更具体地是四氢喹啉化合物的血红蛋白生成增强剂 由通式（1）表示[其中R1，R2，R2'，R3和R3'独立地表示氢原子，C1-6烷基等; R 4，R 5，R 6，R 7，R 8，R 9和R 10独立地表示氢原子，卤素原子，C 1-6烷基等; A表示N-R11，硫原子或氧原子; R 11表示氢原子，C 1-6烷基等; B表示C 6-14芳基或5至10元杂环基; n表示0或1的整数]，四氢喹啉化合物的盐或四氢喹啉化合物或其盐的溶剂合物。

公开(公告)号：US20090131330A1

公开(公告)日：2009-05-21

申请号：US11722952

申请日：2005-12-27

Applicant: Hiroyuki Ishiwata ,  Mototsugu Kabeya ,  Toru Kanke

Inventor： Hiroyuki Ishiwata ,  Mototsugu Kabeya ,  Toru Kanke

IPC: A61K38/00 ,  C07K5/00 ,  A61P1/00

CPC classification number: C07K5/1016 ,  A61K38/00 ,  C07K7/06

Abstract: Disclosed is a compound represented by the following general formula (1): Ar—CO-AA1-AA2-AA3-AA4-NH—X—NR1R2 (1) (wherein Ar represents an optionally substituted phenyl group or an aromatic heterocyclic group; AA1 represents a hydrophobic amino acid; AA2 represents an unsubstituted amino acid containing 2 or more carbon atoms; AA3 represents an unsubstituted amino acid containing 2 or more carbon atoms; AA4 represents a hydrophobic amino acid; X represents a divalent saturated aliphatic hydrocarbon group having 2-6 carbon atoms; and R1 and R2 may be the same or different and independently represent a saturated or unsubstituted aliphatic hydrocarbon group having 1-8 carbon atoms, or alternatively R1 and R2 may form a ring together with an adjacent nitrogen atom), a salt thereof, or a solvate of them. Also disclosed is a pharmaceutical composition for prevention/treatment of diseases associated with PAR-2 which is composed of the compound represented by the above general formula (1), a salt thereof or a solvate of them and a pharmaceutically acceptable carrier.

Abstract translation: 公开了由以下通式（1）表示的化合物：Ar-CO-AA1-AA2-AA3-AA4-NH-X-NR1R2（1）（其中Ar表示任选取代的苯基或芳族杂环基; AA1 表示疏水性氨基酸; AA2表示含有2个以上碳原子的未取代氨基酸; AA3表示含有2个以上碳原子的未取代氨基酸; AA4表示疏水性氨基酸; X表示二价饱和脂肪族烃基， 6个碳原子; R1和R2可以相同或不同，并且独立地表示具有1-8个碳原子的饱和或未取代的脂族烃基，或者R1和R2可以与相邻的氮原子一起形成环），盐 或它们的溶剂合物。 还公开了用于预防/治疗与由上述通式（1）表示的化合物，其盐或它们的溶剂化物和药学上可接受的载体组成的PAR-2相关疾病的药物组合物。

公开(公告)号：US07496332B2

公开(公告)日：2009-02-24

申请号：US11061075

申请日：2005-02-17

Applicant: Hiroyuki Ishiwata ,  Takashi Tanemura ,  Akiyuki Yoshisato ,  Masami Miyazaki

Inventor： Hiroyuki Ishiwata ,  Takashi Tanemura ,  Akiyuki Yoshisato ,  Masami Miyazaki

IPC: H04B1/40

CPC classification number: H03H7/463

Abstract: A diplexer contains a common terminal connected to an antenna, a first input/output terminal for inputting/outputting signals of a plurality of high frequency bands higher than a predetermined frequency, and a second input/output terminal for inputting/outputting signals of low frequency bands lower than the predetermined frequency. Between the common terminal and the first input/output terminal, a high pass filter and low trap circuits for attenuating the low frequency bands respectively are interposed in series, and, between the common terminal and the second input/output terminal, a low pass filter and high trap circuits for attenuating the high frequency bands respectively are interposed in series.

Abstract translation: 双工器包括连接到天线的公共端子，用于输入/输出高于预定频率的多个高频带的信号的第一输入/输出端子和用于输入/输出低频信号的第二输入/输出端子 频带低于预定频率。 在公共端子和第一输入/输出端子之间，分别插入用于衰减低频带的高通滤波器和低陷波电路，并且在公共端子和第二输入/输出端子之间设置低通滤波器 并且分别插入用于衰减高频带的高陷波电路。

公开(公告)号：US07196101B2

公开(公告)日：2007-03-27

申请号：US10690671

申请日：2003-10-23

Applicant: Hiroyuki Ishiwata ,  Seiichi Sato ,  Mototsugu Kabeya ,  Soichi Oda ,  Makoto Suda ,  Manabu Shibasaki

Inventor： Hiroyuki Ishiwata ,  Seiichi Sato ,  Mototsugu Kabeya ,  Soichi Oda ,  Makoto Suda ,  Manabu Shibasaki

IPC: A61P37/08 ,  A61K31/44 ,  C07D213/00

CPC classification number: C07D487/04 ,  C07D213/74 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

Abstract translation: 由式（1）表示的双（5-芳基-2-吡啶基）化合物或其盐：

公开(公告)号：US20060147976A1

公开(公告)日：2006-07-06

申请号：US11350955

申请日：2006-02-10

Applicant: Akihiko Maruyama ,  Takanori Higashihara ,  Hiroyuki Ishiwata ,  Tsunemi Fujita

Inventor： Akihiko Maruyama ,  Takanori Higashihara ,  Hiroyuki Ishiwata ,  Tsunemi Fujita

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/689 ,  C12N15/11 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/64

Abstract: A method of detecting and quantitating a petroleum-digesting microorganism and its gene from natural environment. In one embodiment, the microorganism is a bacterium belonging to the genus Cycloclasticus. The invention also relates to a method for detecting and quantitating a petroleum-degrading bacterium belonging to the genus Cycloclasticus comprising using an RNA or DNA probe having a length of from 10 to 50 bases with a part of the nucleotide sequence of the probe represented by any of SEQ ID NOS: 1 to 4; and wherein the probe is hybridizable specifically with a petroleum-degrading bacterium belonging to the genus Cycloclasticus.

Abstract translation: 一种从天然环境中检测和定量石油消化微生物及其基因的方法。 在一个实施方式中，所述微生物是属于环状克氏杆菌属的细菌。 本发明还涉及一种用于检测和定量属于旋毛虫属的降解石油的细菌的方法，其包括使用长度为10至50个碱基的RNA或DNA探针，其中部分探针的核苷酸序列由任何 SEQ ID NO：1至4; 并且其中所述探针与属于旋毛虫属的石油降解细菌特异性杂交。

公开(公告)号：US06890940B2

公开(公告)日：2005-05-10

申请号：US09893680

申请日：2001-06-29

Applicant: Hiroyuki Ishiwata ,  Seiichi Sato ,  Mototsugu Kabeya ,  Soichi Oda ,  Makoto Suda ,  Manabu Shibasaki

Inventor： Hiroyuki Ishiwata ,  Seiichi Sato ,  Mototsugu Kabeya ,  Soichi Oda ,  Makoto Suda ,  Manabu Shibasaki

IPC: A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07D213/74 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44 ,  C07D213/00

CPC classification number: C07D213/74 ,  C07D401/14 ,  C07D405/14

Abstract: A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbon group, and X is a substituent having one of the following formulas (2) to (4): wherein, in formula (2), R1 is a hydrogen atom or a di(lower alkyl)amino(lower alkyl) group, and m is an integer of 1 or 2; in formula (3), Y1 and Y2 each is a nitrogen atom or a CH group, and n is 0 or an integer of 1 to 6; in formula (4), R2 and R3 each is a hydrogen atom or a lower alkyl group, Z represents a single bond, a substituted methylene group, a substituted imino group, an oxygen atom or a cycloalkylene group, and p and q each is 0 or an integer of 1 to 6.

Abstract translation: 具有式（1）的双（2-芳基-5-吡啶基）化合物或其盐：其中A是取代或未取代的芳族烃基，X是具有下式（2）至（4）中的一个的取代基 ）其中，在式（2）中，R 1是氢原子或二（低级烷基）氨基（低级烷基）基团，m是1或2的整数; 在式（3）中，Y 1和Y 2各自为氮原子或CH基团，n为0或1至6的整数; 在式（4）中，R 2和R 3各自为氢原子或低级烷基，Z表示单键，取代亚甲基，取代亚氨基 基团，氧原子或亚环烷基，p和q各自为0或1〜6的整数。

公开(公告)号：US08575153B2

公开(公告)日：2013-11-05

申请号：US13131561

申请日：2009-11-27

Applicant: Takahiro Kitamura ,  Hajime Yamada ,  Shunji Takemura ,  Masanori Ashikawa ,  Tetsuya Ishikawa ,  Yoshiharu Miyake ,  Akiyasu Kouketsu ,  Seiichi Sato ,  Hiroyuki Ishiwata ,  Yuichiro Tabunoki ,  Manabu Shibasaki ,  Takatoshi Ozawa ,  Ryota Shigemi ,  Takeshi Doi ,  Masahiro Tamura

Inventor： Takahiro Kitamura ,  Hajime Yamada ,  Shunji Takemura ,  Masanori Ashikawa ,  Tetsuya Ishikawa ,  Yoshiharu Miyake ,  Akiyasu Kouketsu ,  Seiichi Sato ,  Hiroyuki Ishiwata ,  Yuichiro Tabunoki ,  Manabu Shibasaki ,  Takatoshi Ozawa ,  Ryota Shigemi ,  Takeshi Doi ,  Masahiro Tamura

IPC: A61K31/506 ,  C07D239/48

CPC classification number: C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.

Abstract translation: 提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂 过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。 由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂化物。

公开(公告)号：US07910556B2

公开(公告)日：2011-03-22

申请号：US11722952

申请日：2005-12-27

Applicant: Hiroyuki Ishiwata ,  Mototsugu Kabeya ,  Toru Kanke

Inventor： Hiroyuki Ishiwata ,  Mototsugu Kabeya ,  Toru Kanke

IPC: A61K38/07 ,  C07K5/10

CPC classification number: C07K5/1016 ,  A61K38/00 ,  C07K7/06

Abstract: A compound, or a salt or solvate thereof having a structure of Ar—CO-AA1-AA2-AA3-AA4-NH—X—NR1R2 is disclosed. Ar represents an optionally substituted phenyl group or an aromatic heterocyclic group; AA1 represents a hydrophobic amino acid; AA2 represents an unsubstituted amino acid containing 2 or more carbon atoms; AA3 represents an unsubstituted amino acid containing 2 or more carbon atoms; AA4 represents a hydrophobic amino acid; X represents a divalent saturated aliphatic hydrocarbon group having 2-6 carbon atoms; and R1 and R2 represent a saturated or unsubstituted aliphatic hydrocarbon group having 1-8 carbon atoms, or alternatively R1 and R2 may form a ring together with an adjacent nitrogen atom. A pharmaceutical composition for prevention/treatment of diseases associated with PAR-2 is also disclosed. The pharmaceutical composition includes the above compound, a salt or a solvate thereof and a pharmaceutically acceptable carrier.

Abstract translation: 公开了具有Ar-CO-AA1-AA2-AA3-AA4-NH-X-NR1R2结构的化合物或其盐或溶剂化物。 Ar表示可以具有取代基的苯基或芳香族杂环基; AA1表示疏水性氨基酸; AA2表示含有2个以上碳原子的未取代氨基酸; AA3表示含有2个以上碳原子的未取代氨基酸; AA4表示疏水性氨基酸; X表示具有2-6个碳原子的二价饱和脂族烃基; 并且R 1和R 2表示具有1-8个碳原子的饱和或未取代的脂族烃基，或者R 1和R 2可以与相邻的氮原子一起形成环。 还公开了用于预防/治疗与PAR-2相关的疾病的药物组合物。 药物组合物包括上述化合物，其盐或其溶剂化物和药学上可接受的载体。

公开(公告)号：US20100222347A1

公开(公告)日：2010-09-02

申请号：US12680307

申请日：2008-09-29

Applicant: Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

Inventor： Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

IPC: A61K31/5377 ,  C07D215/08 ,  A61K31/4706 ,  C07D413/12 ,  C07D215/233 ,  A61K31/47 ,  A61P7/00

CPC classification number: C07D215/48 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/44 ,  C07D413/04 ,  C07D413/12

Abstract: Disclosed is a low-molecular-weight compound having an EPO production-promoting activity and/or a hemoglobin expression-enhancing activity. Specifically disclosed is an EPO production promoter and/or a hemoglobin expression enhancer comprising a 1-acyl-4-(phenoxy, benzyloxy or phenylamino)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by the general formula (1); [wherein R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11 or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

Abstract translation: 公开了具有EPO生产促进活性和/或血红蛋白表达增强活性的低分子量化合物。 具体公开的是EPO生产促进剂和/或血红蛋白表达增强剂，其包含1-酰基-4-（苯氧基，苄氧基或苯基氨基）-1,2,3,4-四氢喹啉衍生物，更具体地是由通式 公式1）; [其中R1，R2，R2'，R3和R3'独立地表示氢原子，C1-6烷基等; R 4，R 5，R 6，R 7，R 8，R 9和R 10独立地表示氢原子，卤素原子，C 1-6烷基等; A表示N-R11或氧原子; R 11表示氢原子，C 1-6烷基等; n表示0或1的整数]，四氢喹啉化合物的盐或四氢喹啉化合物或其盐的溶剂合物。

公开(公告)号：US07423500B2

公开(公告)日：2008-09-09

申请号：US11521756

申请日：2006-09-15

Applicant: Hiroyuki Ishiwata

Inventor： Hiroyuki Ishiwata

IPC: H03H7/00

CPC classification number: H03H7/0115 ,  H01P1/2039 ,  H03H7/1758 ,  H03H2001/0085

Abstract: A plurality of conductive patterns constituting first, second, and third inductors are formed in a multi-layer wiring board. A fifth dielectric layer is disposed between second to fourth dielectric layers having the first inductor and a seventh dielectric layer having the second inductor. First and second electrode layers are disposed facing each other across the fifth dielectric layer so as to constitute a capacitor. The capacitor is disposed between the first and third inductors and the second inductor. The first electrode layer, i.e., one electrode of the capacitor, is a ground layer.

Abstract translation: 构成第一，第二和第三电感器的多个导电图案形成在多层布线板中。 第五电介质层设置在具有第一电感器的第二至第四电介质层和具有第二电感器的第七电介质层之间。 第一电极层和第二电极层跨越第五电介质层彼此面对地布置以构成电容器。 电容器设置在第一和第三电感器和第二电感器之间。 第一电极层，即电容器的一个电极，是接地层。