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公开(公告)号：US20100209948A1
公开(公告)日：2010-08-19
申请号：US12694639
申请日：2010-01-27
Applicant: Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Yi-Ting Chen , Chwei-Shiun Yang
Inventor： Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Yi-Ting Chen , Chwei-Shiun Yang
IPC: G01N33/53
CPC classification number: G01N33/6893 , C07K14/70503 , C07K16/2803 , G01N2333/4728 , G01N2333/70503 , G01N2800/347 , G01N2800/52 , G01N2800/56
Abstract: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.
Abstract translation: 使用尿生物标志物诊断肾病，监测肾病进展，并评估肾病治疗的疗效。 这些尿生物标志物包括白细胞相关的Ig样受体-2，α-1酸性糖蛋白，其片段及其组合。
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公开(公告)号：US20100197033A1
公开(公告)日：2010-08-05
申请号：US12694575
申请日：2010-01-27
Applicant: Wei-Ya Lin , Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ping-Fu Cheng , Tsai-Wei Hsu , Hung-Yi Li , Yi-Ting Chen , Yuh-Feng Ling , Jin-Shuen Chen , Yen-Peng Li
Inventor： Wei-Ya Lin , Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ping-Fu Cheng , Tsai-Wei Hsu , Hung-Yi Li , Yi-Ting Chen , Yuh-Feng Ling , Jin-Shuen Chen , Yen-Peng Li
IPC: G01N33/48
CPC classification number: G01N33/6893 , G01N2333/4728 , G01N2333/52 , G01N2333/71 , G01N2333/8125 , G01N2800/347 , G01N2800/52 , G01N2800/56
Abstract: Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.
Abstract translation: 使用尿液和血清生物标志物诊断糖尿病肾病，分期糖尿病肾病，监测糖尿病肾病进展，评估糖尿病肾病治疗效果。 这些生物标志物包括尿前体α-2-HS-糖蛋白，尿α-1抗胰蛋白酶，尿α-1酸糖蛋白，尿骨桥蛋白，血清骨桥蛋白，其片段及其组合。
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公开(公告)号：US08476077B2
公开(公告)日：2013-07-02
申请号：US12969039
申请日：2010-12-15
Applicant: Wei-Ya Lin , Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ping-Fu Cheng , Tsai-Wei Hsu , Hung-Yi Li , Yi-Ting Chen , Yuh-Feng Ling , Jin-Shuen Chen , Yen-Peng Li
Inventor： Wei-Ya Lin , Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ping-Fu Cheng , Tsai-Wei Hsu , Hung-Yi Li , Yi-Ting Chen , Yuh-Feng Ling , Jin-Shuen Chen , Yen-Peng Li
CPC classification number: G01N33/6893 , G01N2333/4728 , G01N2333/52 , G01N2333/71 , G01N2333/8125 , G01N2800/347 , G01N2800/52 , G01N2800/56
Abstract: Disclosed is use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.
Abstract translation: 公开了使用尿液和血清生物标志物诊断糖尿病肾病，分期糖尿病肾病，监测糖尿病肾病进展和评估糖尿病肾病治疗效果。 这些生物标志物包括尿前体α-2-HS-糖蛋白，尿α-1抗胰蛋白酶，尿α-1酸糖蛋白，尿骨桥蛋白，血清骨桥蛋白，其片段及其组合。
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公开(公告)号：US08076089B2
公开(公告)日：2011-12-13
申请号：US12763453
申请日：2010-04-20
Applicant: Tzu Ling Tseng , Ping Fu Cheng
Inventor： Tzu Ling Tseng , Ping Fu Cheng
IPC: G01N33/53
CPC classification number: G01N33/57438 , G01N33/6893 , G01N2800/08 , G01N2800/085
Abstract: Biomarkers for liver diseases and method for using the same are provided. For detecting liver cirrhosis and liver cancer, the biomarkers are selected from any one of the amino acid sequences with SEQ ID NO:1 to SEQ ID NO:24 or derivatives or fragments or variants or the combination thereof or the antibodies against the amino acid sequences. Then the biomarkers are further developed into detection kits, such that by detecting the existence of autoantibodies or autoantigens in screened specimens, liver diseases are detected with higher accuracy and sensitivity.
Abstract translation: 提供肝脏疾病的生物标志物及其使用方法。 为了检测肝硬化和肝癌，生物标志物选自SEQ ID NO：1至SEQ ID NO：24的任一氨基酸序列或衍生物或片段或变体或其组合或针对氨基酸序列的抗体 。 然后生物标志物进一步发展为检测试剂盒，通过检测筛选标本中自身抗体或自身抗原的存在，以更高的准确度和灵敏度检测肝脏疾病。
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公开(公告)号：US20110086372A1
公开(公告)日：2011-04-14
申请号：US12973018
申请日：2010-12-20
Applicant: Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Yi-Ting Chen , Chwei-Shiun Yang
Inventor： Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Yi-Ting Chen , Chwei-Shiun Yang
CPC classification number: G01N33/6893 , C07K14/70503 , C07K16/2803 , G01N2333/4728 , G01N2333/70503 , G01N2800/347 , G01N2800/52 , G01N2800/56
Abstract: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.
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Patent Agency Ranking
公开(公告)号：US20110081667A1
公开(公告)日：2011-04-07
申请号：US12968841
申请日：2010-12-15
Applicant: Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Yi-Ting Chen , Chwei-Shiun Yang
Inventor： Mary Ya-Ping Yeh , Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Yi-Ting Chen , Chwei-Shiun Yang
CPC classification number: G01N33/6893 , C07K14/70503 , C07K16/2803 , G01N2333/4728 , G01N2333/70503 , G01N2800/347 , G01N2800/52 , G01N2800/56
Abstract: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.
Abstract translation: 使用尿生物标志物诊断肾病，监测肾病进展，并评估肾病治疗的疗效。 这些尿生物标志物包括白细胞相关的Ig样受体-2，α-1酸性糖蛋白，其片段及其组合。
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公开(公告)号：US20100136579A1
公开(公告)日：2010-06-03
申请号：US12628758
申请日：2009-12-01
Applicant: Tzu-Ling Tseng , Hung-Yi Li , Yen-Peng Li , Angelina Huai-Lo Lee , Yi-Chen Liu , Ping-Fu Cheng , Wei-Ya Lin , Hong-Zen Yeh
Inventor： Tzu-Ling Tseng , Hung-Yi Li , Yen-Peng Li , Angelina Huai-Lo Lee , Yi-Chen Liu , Ping-Fu Cheng , Wei-Ya Lin , Hong-Zen Yeh
IPC: G01N33/573 , C12Q1/52 , C12Q1/37
CPC classification number: G01N33/6893 , G01N33/487 , G01N33/49 , G01N33/50 , G01N33/5067 , G01N33/53 , G01N33/576 , G01N2333/70539 , G01N2333/96494 , G01N2333/9723 , G01N2800/085
Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.
Abstract translation: 鉴定尿激酶型纤溶酶原，基质金属蛋白酶9和＆bgr.2-微球蛋白作为与肝纤维化相关的新型生物标志物及其在诊断肝纤维化中的用途。
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公开(公告)号：US20080241863A1
公开(公告)日：2008-10-02
申请号：US12073603
申请日：2008-03-07
Applicant: Tzu-Ling Tseng , Ping-Fu Cheng
Inventor： Tzu-Ling Tseng , Ping-Fu Cheng
IPC: G01N33/53
CPC classification number: G01N33/57438 , G01N33/6893 , G01N2800/08 , G01N2800/085
Abstract: Biomarkers for liver diseases and method for using the same are provided. For detecting liver cirrhosis and liver cancer, the biomarkers are selected from any one of the amino acid sequences with SEQ ID NO:1 to SEQ ID NO:24 or derivatives or fragments or variants or the combination thereof or the antibodies against the amino acid sequences. Then the biomarkers are further developed into detection kits, such that by detecting the existence of autoantibodies or autoantigens in screened specimens, liver diseases are detected with higher accuracy and sensitivity.
Abstract translation: 提供肝脏疾病的生物标志物及其使用方法。 为了检测肝硬化和肝癌，生物标志物选自SEQ ID NO：1至SEQ ID NO：24的任一氨基酸序列或衍生物或片段或变体或其组合或针对氨基酸序列的抗体 。 然后生物标志物进一步发展为检测试剂盒，通过检测筛选标本中自身抗体或自身抗原的存在，以更高的准确度和灵敏度检测肝脏疾病。
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公开(公告)号：US08470547B2
公开(公告)日：2013-06-25
申请号：US12969731
申请日：2010-12-16
Applicant: Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Mary Ya-Ping Yeh , Yi-Ting Chen , Chwei-Shiun Yang
Inventor： Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Mary Ya-Ping Yeh , Yi-Ting Chen , Chwei-Shiun Yang
CPC classification number: G01N33/6893 , C07K14/70503 , C07K16/2803 , G01N2333/4728 , G01N2333/70503 , G01N2800/347 , G01N2800/52 , G01N2800/56
Abstract: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.
Abstract translation: 使用尿生物标志物诊断肾病，监测肾病进展，并评估肾病治疗的疗效。 这些尿生物标志物包括白细胞相关的Ig样受体-2，α-1酸性糖蛋白，其片段及其组合。
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20.发明申请公开(公告)号：US20070154955A1
公开(公告)日：2007-07-05
申请号：US11320665
申请日：2005-12-30
Applicant: Tzu-Ling Tseng , Ping-Fu Cheng , Shyh-Shin Chiou
Inventor： Tzu-Ling Tseng , Ping-Fu Cheng , Shyh-Shin Chiou
IPC: G01N33/567 , G01N33/53
CPC classification number: G01N33/564 , G01N33/6854 , G01N2800/04
Abstract: A method of diagnosing autoimmune polyglandular syndrome (APS) in a subject, and a kit for identifying a subject having autoimmune polyglandular syndrome (APS) are provided.
Abstract translation: 本发明提供一种诊断受试者自身免疫多腺综合征（APS）的方法，以及用于鉴定具有自身免疫性多腺综合征（APS）的受试者的试剂盒。
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