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19 条记录 (耗时 0.019 秒)

    Method for using a carbamoyl fluoride as fluorinating agent
    12.
    发明授权
    Method for using a carbamoyl fluoride as fluorinating agent 失效
    使用氨基甲酰氟作为氟化剂的方法

    公开(公告)号：US06833476B2

    公开(公告)日：2004-12-21

    申请号：US10450600

    申请日：2003-10-17

    申请人： Laurent Saint-Jalmes ,  Vincent Schanen ,  Gilbert Guidot ,  Hubert Kempf

    发明人： Laurent Saint-Jalmes ,  Vincent Schanen ,  Gilbert Guidot ,  Hubert Kempf

    IPC分类号： C07C5158

    CPC分类号： C07C263/16 ,  C07B39/00 ,  C07C265/12

    摘要： The invention concerns a method for using a carbamoyl fluoride as fluorinating agent. Said method consists in treating a derivative bearing a halogen-containing carbon, with a carbamoyl fluoride at a temperature not less than 70 ° C. and in maintaining the ratio between the sum of hydrofluoric acid (HF) and carbamoyl fluoride as well as between the sum of exchangeable halogen atoms, isocyanate functions and carbamoyl fluoride [(HF+carbamoyl fluoride)/(exchangeable halogen+isocyanate+carbamoyl fluoride)] at a value not more than 1.2; then in carrying out a catalysis process with tin, antimony and/or titanium salt. The invention is applicable to synthesis of fluorinated derivatives.

    摘要翻译： 本发明涉及使用氨基甲酰氟作为氟化剂的方法。 所述方法包括用温度不低于70℃的氨基甲酰氟处理带有含卤素碳的衍生物，并保持氢氟酸（HF）和氨基甲酰氟之和之间的比率 可交换的卤素原子，异氰酸酯官能团和氨基甲酰氟[（HF +氨基甲酰氟）/（可交换卤素+异氰酸酯+氨基甲酰氟）]的数值不超过1.2; 然后用锡，锑和/或钛盐进行催化过程。 本发明适用于氟化衍生物的合成。

    Method for preparing trifluoromethanesulphinic acid
    14.
    发明授权
    Method for preparing trifluoromethanesulphinic acid 有权
    三氟甲磺酸的制备方法

    公开(公告)号：US08633334B2

    公开(公告)日：2014-01-21

    申请号：US12744875

    申请日：2008-11-25

    申请人： Vincent Schanen ,  Olivier Buisine ,  François Metz ,  Bernard Besson

    发明人： Vincent Schanen ,  Olivier Buisine ,  François Metz ,  Bernard Besson

    IPC分类号： C07C313/04

    CPC分类号： C07C313/04

    摘要： The present invention relates to a method for preparing a highly pure trifluoromethanesulphinic acid. The method of the invention for preparing a highly pure trifluoromethanesulphinic acid, starting from an aqueous mixture comprising a trifluoromethanesulphinic acid salt, a trifluoroacetic acid salt and saline impurities resulting from the method for preparing same, is characterized in that said mixture is subjected to the following operations: —acidification such that the trifluoroacetic acid salt and the triflinic acid salt are released in an acid form, —separation of the trifluoroacetic acid and trifluoromethanesulphinic acid by distillation enabling the trifluoroacetic acid to be recovered at the top of the distillation and the trifluoromethanesulphinic acid to be recovered at the bottom of the distillation, —separation by distillation of the trifluoromethanesulphinic acid present in the distillation residue previously obtained.

    摘要翻译： 本发明涉及一种制备高纯度三氟甲磺酸的方法。 本发明制备高纯度三氟甲磺酸的方法，其特征在于，由包含三氟甲磺酸盐，三氟乙酸盐和由其制备方法得到的盐水杂质的含水混合物开始，将所述混合物进行以下步骤 操作：酸化使得三氟乙酸盐和三氟甲磺酸盐以酸的形式释放，通过蒸馏分离三氟乙酸和三氟甲磺酸，使得三氟乙酸在蒸馏顶部回收，并且三氟甲亚磺酸 在蒸馏的底部回收，通过蒸馏先前获得的蒸馏残余物中存在的三氟甲亚磺酸分离。

    USE OF A COMPOSITION OF AN IONIC NATURE AS A SUBSTITUTION REAGENT, A COMPOSITION CONSTITUTING A FLUORINATION REAGENT AND A METHOD USING SAME
    16.
    发明申请
    USE OF A COMPOSITION OF AN IONIC NATURE AS A SUBSTITUTION REAGENT, A COMPOSITION CONSTITUTING A FLUORINATION REAGENT AND A METHOD USING SAME 审中-公开
    使用作为替代试剂的离子性质的组合物，构成荧光试剂的组合物和使用其的方法

    公开(公告)号：US20090036718A1

    公开(公告)日：2009-02-05

    申请号：US12113232

    申请日：2008-05-01

    申请人： Rene GREE ,  Vincent Schanen ,  Jean-Francis Spindler ,  Maxime Garayt ,  Virginie Le Boulaire ,  Danielle Gree

    发明人： Rene GREE ,  Vincent Schanen ,  Jean-Francis Spindler ,  Maxime Garayt ,  Virginie Le Boulaire ,  Danielle Gree

    IPC分类号： C07C25/13

    CPC分类号： C07D231/12 ,  C07B39/00 ,  C07C17/208 ,  C07C205/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/54 ,  Y02P20/542 ,  C07C25/13 ,  C07C22/08

    摘要： The invention relates to processes for aromatic nucleophilic substitution by contacting a substrate of formula (III) Ar-Ξ  (III) where Ar is an aromatic group where the nucleus carrying the group Ξ is electron-poor, either because it contains at least one heteroatom in its ring or because the sum of the Hammett constants, σp, of its substituents, apart from said Ξ, is at least 0.2, and Ξ is a leaving group, with a composition containing at least one ionic compound whose cation is of general formula G: (R10)(R9)N—[C(R8)═C(R6)]ν—C(R5)═N+(R1)(R2)  (G) wherein: ν is an integer from 0 to 4, inclusive; R1, R2, R5, R6 and R8, which are identical or different, are a hydrogen or a hydrocarbon group; and R9 and R10, which are identical or different, are a hydrocarbon group; or one or two of the substituents R1, R2, R5, R8, R9, and R10 are connected to other remaining substituent(s) to form one or two or more rings.

    摘要翻译： 本发明涉及芳族亲核取代的方法，该方法是通过使式（III）的底物与式（III）<？in-line-formula description =“In-line Formulas”end =“lead”→Ar-Xi（III） line-formula description =“In-line Formulas”end =“tail”？>其中Ar是芳族基团，其中携带基团Xi的核是电子贫乏的，或者是因为它在其环中含有至少一个杂原子，或者因为 除了所述Xi之外，其取代基的哈米特常数sigmap的和为至少0.2，并且Xi为离去基团，组合物含有至少一种阳离子为通式G的离子化合物： （R 10）（R 9）N- [C（R 8）-C（R 6）] nu-C（R 5）-N +（R 1）（R 2） ）（G）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中：nu是0至4的整数，包括0和4; R 1，R 2，R 5，R 6和R 8相同或不同，为氢或烃基; 和R 9和R 10相同或不同，为烃基; 或取代基R 1，R 2，R 5，R 8，R 9和R 10中的一个或两个连接到其它剩余的取代基以形成一个或两个或更多个环。

    Process for 3,4-disubstituted dinitroanilines
    18.
    发明授权
    Process for 3,4-disubstituted dinitroanilines 失效
    3,4-二取代二硝基苯胺的方法

    公开(公告)号：US6028226A

    公开(公告)日：2000-02-22

    申请号：US056415

    申请日：1998-04-07

    申请人： Joseph Schapira ,  Jean-Claude Cheminaud ,  Jean-Jacques Gasse ,  Vincent Schanen ,  Benoit Rondot ,  Jean-Claude Lemoine

    发明人： Joseph Schapira ,  Jean-Claude Cheminaud ,  Jean-Jacques Gasse ,  Vincent Schanen ,  Benoit Rondot ,  Jean-Claude Lemoine

    IPC分类号： C07C209/18 ,  C07C213/00

    CPC分类号： C07C209/18

    摘要： Preparation process for 3,4-disubstituted dinitroanilines of formula ##STR1## in which, R.sub.1 and R.sub.2, which are identical to or different from one another, represent a hydrogen atom, a C.sub.1 to C.sub.6 saturated, linear or branched alkyl radical, a C.sub.2 to C.sub.6 linear or branched alkylene radical, a cyclopropyl radical or a chloroethyl radical,R.sub.3 and R.sub.4, which are identical to or different from one another are chosen from the group containing the chlorine atom, the amino group, the C.sub.1 to C.sub.3 lower alkyl radicals and the trifluoromethyl radical,comprising successively a dinitration stage of a 3,4-disubstituted phenol, an alkylation stage of the dinitrated derivative thus obtained and an amination stage of the 3,4-disubstituted 2,6-dinitro-alkoxybenzene thus obtained.

    摘要翻译： 其中R1和R2彼此相同或不同的3,4-二取代二硝基苯胺的制备方法代表氢原子，C1-C6饱和，直链或支链烷基，C2至C6直链 或支链亚烷基，环丙基或氯乙基，R3和R4彼此相同或不同，选自含有氯原子，氨基，C1至C3低级烷基和三氟甲基的基团 自由基，连续地包括3,4-二取代苯酚的二硝化阶段，如此获得的二硝基衍生物的烷基化阶段和由此获得的3,4-二取代2,6-二硝基 - 烷氧基苯胺的胺化阶段。

    Preparation process for 4-substituted dinitroanilines
    19.
    发明授权
    Preparation process for 4-substituted dinitroanilines 失效
    4-取代二硝基苯胺的制备方法

    公开(公告)号：US5981800A

    公开(公告)日：1999-11-09

    申请号：US56266

    申请日：1998-04-07

    申请人： Joseph Schapira ,  Jean-Claude Cheminaud ,  Jean-Jacques Gasse ,  Vincent Schanen ,  Benoit Rondot ,  Jean-Claude Lemoine

    发明人： Joseph Schapira ,  Jean-Claude Cheminaud ,  Jean-Jacques Gasse ,  Vincent Schanen ,  Benoit Rondot ,  Jean-Claude Lemoine

    IPC分类号： C07C205/22 ,  C07C205/23 ,  C07C205/37 ,  C07C209/18 ,  C07C211/52

    CPC分类号： C07C209/18 ,  C07C201/08

    摘要： Preparation process for 4-substituted dinitroanilines of formula ##STR1## in which R.sub.1 is chosen from the group containing the tert-butyl, sulphonamido, trifluoromethyl, methyl-sulphonyl and isopropyl radicals,R.sub.2 and R.sub.3, which are identical to or different from one another, represent a hydrogen atom, a linear or branched alkyl, cycloalkyl, haloalkyl or alkenyl radical containing less than 6 carbon atoms, characterized in that that it comprises successively:a dinitration stage of the 4-substituted phenol corresponding to the sought 4-substituted dinitro-aniline, this dinitration stage being carried out in a reaction medium containing a slight excess of nitrating agent, a sufficient quantity of protons and a catalyst chosen from the group containing the soluble salts of the transition metals of columns IV to XII of the Periodic Table, preferably the soluble salts of Fe.sub.III, Fe.sub.II, Zn.sub.II and Cu.sub.II ions,an O-alkylation stage of the dinitrated 4-substituted phenol obtained in the preceding stage, by means of an alkylating agent, andan amination stage of the 4-substituted dinitrated phenoxy-ether obtained in the preceding stage by using a primary or secondary amine.

    摘要翻译： 其中R1选自含有叔丁基，磺酰氨基，三氟甲基，甲基 - 磺酰基和异丙基的基团的4-取代二硝基苯胺的制备方法，R 2和R 3彼此相同或不同，表示 氢原子，含有少于6个碳原子的直链或支链烷基，环烷基，卤代烷基或链烯基，其特征在于它包括依次：对应于所寻求的4-取代二硝基苯胺的4-取代苯酚的二硝化阶段， 该二硝化阶段在含有略过量的硝化剂，足够量的质子和选自含有周期表第IV至第Ⅻ族的过渡金属的可溶性盐的基团的反应介质中进行，优选地 FeIII，FeII，ZnII和CuII离子的可溶性盐，前一阶段得到的二硝基四取代苯酚的O-烷基化阶段，m 烷基化试剂的酯，和通过使用伯胺或仲胺在前一阶段获得的4-取代二硝基苯氧基醚的胺化阶段。