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11.发明授权1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives 失效1-芳基-2-N-，S-或O-取代的苯并咪唑衍生物，其用于生产药物的用途以及含有这些衍生物的药物制剂公开(公告)号：US06903126B2
公开(公告)日：2005-06-07
申请号：US10190620
申请日：2002-07-09
IPC分类号： C07D235/26 , C07D235/28 , C07D235/30 , C07D401/12 , A61K31/4184
CPC分类号： C07D401/12 , C07D235/26 , C07D235/28 , C07D235/30
摘要： The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
摘要翻译： 本发明涉及具有通式I的新的苯并咪唑衍生物，其中基团R 1，R 2，R 3，A，B，Y和 Z具有在说明书和权利要求书中指出的含义，这些化合物在制备用于治疗和预防与小胶质细胞活化相关的疾病的药剂中的用途以及含有这些化合物的药物制剂
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公开(公告)号：US5827842A
公开(公告)日：1998-10-27
申请号：US578847
申请日：1995-12-26
申请人： Klaus Schollkopf , Wolfgang Halfbrodt , Joachim Kuhnke , Wolfgang Schwede , Karl-Heinrich Fritzemeier , Rolf Krattenmacher , Hans-Peter Muhn
发明人： Klaus Schollkopf , Wolfgang Halfbrodt , Joachim Kuhnke , Wolfgang Schwede , Karl-Heinrich Fritzemeier , Rolf Krattenmacher , Hans-Peter Muhn
CPC分类号： C07J71/0005 , C07J53/00 , Y10S514/841 , Y10S514/843
摘要： The invention describes 14,17-C.sub.2 -bridged steroids of general formula (I), ##STR1## wherein the various R groups are as defined in the specification, and wherein said steroids are, in contrast with the disclaimed compound 14,17-ethano-19-norpregn-4-ene-3,20-dione bioavailable even after peroral administration with high gestagenic action and are suitable for the production of pharmaceutical agents.
摘要翻译： 本发明描述了通式（I），其中各种R基团如本说明书中所定义的通式（I），其中所述类固醇与被弃置的化合物14相反的14,17-C2-桥连类固醇， 即使在口服给药后，即使在具有高孕激素作用的情况下也能生物利用，并且适用于药物制剂的生产，17-乙醇-19-去甲孕-4-烯-3,20-二酮。
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13.发明授权1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives 失效1-苯基-2-杂芳基取代的苯并咪唑衍生物，其用于生产药剂的用途以及含有这些衍生物的药物制剂公开(公告)号：US07683081B2
公开(公告)日：2010-03-23
申请号：US11198098
申请日：2005-08-04
申请人： Thorsten Blume , Bernd Elger , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Herbert Schneider
发明人： Thorsten Blume , Bernd Elger , Wolfgang Halfbrodt , Joachim Kuhnke , Ursula Moenning , Herbert Schneider
IPC分类号： A61K31/4439 , A61K31/4184
CPC分类号： C07D401/04 , C07D409/04 , C07D413/14 , C07D417/14
摘要： New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
摘要翻译： 描述了新的苯并咪唑衍生物，它们的生产及其用于生产用于治疗和预防与小胶质细胞激活和T细胞介导的免疫疾病相关的疾病的药物的用途，以及含有新的苯并咪唑衍生物的药物制剂 。
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公开(公告)号：US07345075B2
公开(公告)日：2008-03-18
申请号：US11305521
申请日：2005-12-16
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
摘要翻译： 描述了通式I的苯并咪唑和苯并咪唑衍生物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药物的用途。
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公开(公告)号：US07329679B2
公开(公告)日：2008-02-12
申请号：US11299135
申请日：2005-12-08
IPC分类号： A61K31/44 , A61K31/415
CPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
摘要翻译： 描述了通式I的苯并咪唑和苯并咪唑衍生物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药物的用途。
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公开(公告)号：US07115645B2
公开(公告)日：2006-10-03
申请号：US09759360
申请日：2001-01-16
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
摘要翻译： 描述了通式I的苯并咪唑和苯并咪唑衍生物用于制备用于治疗和预防与小胶质细胞活化相关的疾病的药物的用途。
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公开(公告)号：US20060094770A1
公开(公告)日：2006-05-04
申请号：US11299135
申请日：2005-12-08
IPC分类号： C07D235/12 , A61K31/4184
CPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
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18.发明授权
公开(公告)号：US6147065A
公开(公告)日：2000-11-14
申请号：US362214
申请日：1999-07-28
申请人： Klaus Schollkopf , Wolfgang Halfbrodt , Joachim Kuhnke , Wolfgang Schwede , Karl-Heinrich Fritzemeier , Rolf Krattenmacher , Hans-Peter Muhn
发明人： Klaus Schollkopf , Wolfgang Halfbrodt , Joachim Kuhnke , Wolfgang Schwede , Karl-Heinrich Fritzemeier , Rolf Krattenmacher , Hans-Peter Muhn
CPC分类号： C07J71/0005 , C07J53/00 , Y10S514/841 , Y10S514/843
摘要： Described are 14,17-C.sub.2 -bridged steroids of the formula (I) defined in the specification. The compounds are available, even after peroral administration, with high gestagenic action and are suitable for the production of pharmaceutical agents.
摘要翻译： 描述了本说明书中定义的式（I）的14,17-C2桥连类固醇。 甚至在口服给药后，化合物也具有高的孕激素作用，并且适用于生产药剂。
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