公开(公告)号：US20120301547A1

公开(公告)日：2012-11-29

申请号：US13512402

申请日：2010-11-22

Applicant: Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

Inventor： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

IPC: A61K9/24 ,  B05D5/00 ,  A61P25/18 ,  A61K9/28 ,  A61K31/519

CPC classification number: A61K9/0004 ,  A61K9/2086 ,  A61K9/2866 ,  A61K31/517

Abstract: A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

Abstract translation: 披露了一种帕培酮双层渗透泵控释片及其制备方法。 双层渗透泵控制释放片剂包括刚性膜，推层，药物层，隔离层和美容涂层，其中刚性膜含有半透性聚合物，致孔剂和/或增塑剂，并且具有 一个或多个药物释放孔在一端，推层包括膨胀材料，渗透剂，粘合剂，着色剂和润滑剂，药物层含有药物活性成分，亲水性聚合物，渗透剂，着色剂 ，润滑剂和抗静电剂，隔离层位于刚性膜的内表面和推层之间，并含有亲水性聚合物。 帕潘立酮双层渗透泵控释片剂在早期阶段呈现出药物释放速率的增加，药物释放速率在后期保持不变。

公开(公告)号：US20090171523A1

公开(公告)日：2009-07-02

申请号：US12341805

申请日：2008-12-22

Applicant: HongBin Luo ,  XuGuang Zhou ,  XiaoHua Tang ,  XinXin Zhang ,  Ting Luo

Inventor： HongBin Luo ,  XuGuang Zhou ,  XiaoHua Tang ,  XinXin Zhang ,  Ting Luo

IPC: B60W20/00 ,  B60W10/04

CPC classification number: B60W20/40 ,  B60K1/02 ,  B60K6/387 ,  B60K6/405 ,  B60K6/442 ,  B60L2240/421 ,  B60L2240/441 ,  B60W10/02 ,  B60W10/06 ,  B60W10/08 ,  B60W10/26 ,  B60W20/00 ,  B60W2510/0638 ,  B60W2510/081 ,  F16D3/66 ,  F16D48/02 ,  F16D2500/1024 ,  F16D2500/1066 ,  F16D2500/3024 ,  F16D2500/30401 ,  F16D2500/7027 ,  F16D2500/70406 ,  F16D2500/7041 ,  Y02T10/6234 ,  Y02T10/6269 ,  Y02T10/6286 ,  Y02T10/642 ,  Y10S903/912 ,  Y10S903/946

Abstract: A control system for a hybrid vehicle controls the various operating modes of the hybrid vehicle. Operating modes of the hybrid vehicle include an electric-only power mode, a series hybrid mode, a series hybrid dual-power mode, and a parallel hybrid tri-power mode. The control system selects one of the operating modes for the hybrid vehicle based on one or more inputs and comparisons. Examples of inputs for the control system include a gear-mode, a present battery storage capacity, a present velocity of the hybrid vehicle, and the previous operating mode of the hybrid power system. The control system may also take into account whether a user has selected the electric-only power mode. The control system may also control the operations of one or more components of the hybrid vehicle while operating in one of the operating modes.

Abstract translation: 用于混合动力车辆的控制系统控制混合动力车辆的各种操作模式。 混合动力车辆的操作模式包括仅电力模式，串联混合模式，串联混合双功率模式和并联混合三功率模式。 控制系统基于一个或多个输入和比较来选择混合动力车辆的一种操作模式。 用于控制系统的输入的示例包括齿轮模式，当前电池存储容量，混合动力车辆的当前速度以及混合动力系统的先前操作模式。 控制系统还可以考虑用户是否选择了电唯一的功率模式。 控制系统还可以在操作模式之一的同时控制混合动力车辆的一个或多个部件的操作。