公开(公告)号：US08920835B2

公开(公告)日：2014-12-30

申请号：US13512402

申请日：2010-11-22

申请人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

发明人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K31/519 ,  A61P25/18 ,  B05D5/00 ,  A61K9/00 ,  A61K9/20 ,  A61K31/517

CPC分类号： A61K9/0004 ,  A61K9/2086 ,  A61K9/2866 ,  A61K31/517

摘要： A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

摘要翻译： 披露了一种帕培酮双层渗透泵控释片及其制备方法。 双层渗透泵控制释放片剂包括刚性膜，推层，药物层，隔离层和美容涂层，其中刚性膜含有半透性聚合物，致孔剂和/或增塑剂，并且具有 一个或多个药物释放孔在一端，推层包括膨胀材料，渗透剂，粘合剂，着色剂和润滑剂，药物层含有药物活性成分，亲水性聚合物，渗透剂，着色剂 ，润滑剂和抗静电剂，隔离层位于刚性膜的内表面和推层之间，并含有亲水性聚合物。 帕潘立酮双层渗透泵控释片剂在早期阶段呈现出药物释放速率的增加，药物释放速率在后期保持不变。

公开(公告)号：US20120301547A1

公开(公告)日：2012-11-29

申请号：US13512402

申请日：2010-11-22

申请人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

发明人： Yong Gan ,  Chunliu Zhu ,  Qingmin Yang ,  Jingyi Wang ,  Xiaoqing Zheng ,  Li Gan ,  Xinxin Zhang

IPC分类号： A61K9/24 ,  B05D5/00 ,  A61P25/18 ,  A61K9/28 ,  A61K31/519

CPC分类号： A61K9/0004 ,  A61K9/2086 ,  A61K9/2866 ,  A61K31/517

摘要： A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

摘要翻译： 披露了一种帕培酮双层渗透泵控释片及其制备方法。 双层渗透泵控制释放片剂包括刚性膜，推层，药物层，隔离层和美容涂层，其中刚性膜含有半透性聚合物，致孔剂和/或增塑剂，并且具有 一个或多个药物释放孔在一端，推层包括膨胀材料，渗透剂，粘合剂，着色剂和润滑剂，药物层含有药物活性成分，亲水性聚合物，渗透剂，着色剂 ，润滑剂和抗静电剂，隔离层位于刚性膜的内表面和推层之间，并含有亲水性聚合物。 帕潘立酮双层渗透泵控释片剂在早期阶段呈现出药物释放速率的增加，药物释放速率在后期保持不变。

公开(公告)号：US08956654B2

公开(公告)日：2015-02-17

申请号：US13254115

申请日：2009-06-02

申请人： Yong Gan ,  Chunliu Zhu ,  Sophie Zhai ,  Robert I. Schmitt ,  Ka Chun A. Chan

发明人： Yong Gan ,  Chunliu Zhu ,  Sophie Zhai ,  Robert I. Schmitt ,  Ka Chun A. Chan

IPC分类号： A61K9/24 ,  A61K9/32 ,  A61K9/00 ,  A61K31/00

CPC分类号： A61K9/0004 ,  A61K31/00

摘要： An osmotic dosage form which comprising: (a) a core comprising a biologically active ingredient; (b) a semi-permeable membrane covering said core; and (c) at least one passageway through the semi-permeable membrane, wherein the semi-permeable membrane comprises ethyl cellulose, an acrylic or methacrylic polymer and a water-soluble plasticizer with the proviso that the semi-permeable membrane comprises no or not more than 15 weight percent of a water-soluble material excluding any water-soluble plasticizer, based on the total dry weight of the semi-permeable membrane.

摘要翻译： 一种渗透剂型，其包含：（a）包含生物活性成分的核心; （b）覆盖所述芯的半透膜; 和（c）通过半透膜的至少一个通道，其中半透膜包括乙基纤维素，丙烯酸或甲基丙烯酸聚合物和水溶性增塑剂，条件是半透膜不包括或不多 不超过15重量％的水溶性材料，不包括任何水溶性增塑剂，基于半透膜的总干重。

公开(公告)号：US20120045485A1

公开(公告)日：2012-02-23

申请号：US13254115

申请日：2009-06-02

申请人： Yong Gan ,  Chunliu Zhu ,  Sophie Zhai ,  Robert I. Schmitt ,  Ka Chun A. Chan

发明人： Yong Gan ,  Chunliu Zhu ,  Sophie Zhai ,  Robert I. Schmitt ,  Ka Chun A. Chan

IPC分类号： A61K9/00 ,  A61K9/62

CPC分类号： A61K9/0004 ,  A61K31/00

摘要： An osmotic dosage form which comprising: (a) a core comprising a biologically active ingredient; (b) a semi-permeable membrane covering said core; and (c) at least one passageway through the semi-permeable membrane, wherein the semi-permeable membrane comprises ethyl cellulose, an acrylic or methacrylic polymer and a water-soluble plasticizer with the proviso that the semi-permeable membrane comprises no or not more than 15 weight percent of a water-soluble material excluding any water-soluble plasticizer, based on the total dry weight of the semi-permeable membrane.

摘要翻译： 一种渗透剂型，其包含：（a）包含生物活性成分的核心; （b）覆盖所述芯的半透膜; 和（c）通过半透膜的至少一个通道，其中半透膜包括乙基纤维素，丙烯酸或甲基丙烯酸聚合物和水溶性增塑剂，条件是半透膜不包括或不多 不超过15重量％的水溶性材料，不包括任何水溶性增塑剂，基于半透膜的总干重。

公开(公告)号：US20190290629A1

公开(公告)日：2019-09-26

申请号：US16442049

申请日：2019-06-14

申请人： Yong Gan ,  Bingxue Meng ,  Yan Liu ,  Chunliu Zhu ,  Shiyan Guo

发明人： Yong Gan ,  Bingxue Meng ,  Yan Liu ,  Chunliu Zhu ,  Shiyan Guo

IPC分类号： A61K31/4439

摘要： Provided are a niraparib sustained and controlled release pharmaceutical composition and use thereof. The sustained and controlled release pharmaceutical composition contains dissolution-improved niraparib and a matrix polymer used for regulating release rate; the steady-state plasma concentration trough value Cmin,ss of the pharmaceutical composition is 0.5-4 μM; the steady-state plasma concentration peak value Cmax,ss is 0.8-6 μM.

公开(公告)号：US20080102118A1

公开(公告)日：2008-05-01

申请号：US11634514

申请日：2006-12-05

申请人： Yong Gan ,  Xinteng Zhou

发明人： Yong Gan ,  Xinteng Zhou

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： A glipizide controlled release composition is provided comprising a drug-layer and a push-layer at a ratio of 1:0.5˜3 by weight. The drug-layer contains glipizide and 40˜99 percent by weight of the drug-layer of hydrophilic polyvinylpyrrolidone homopolymer and/or copolymer carrier. The push-layer comprises about 10 to 80 percent by weight of the push-layer of osmopolymers, about 10 to 80 percent by weight of the push-layer of water-insoluble polymers, and about 5 to 50 percent by weight of the push-layer of osmagents. The composition is used in osmotic pump tablets for controlled release of glipizide useful for administration once a day.

摘要翻译： 提供了含有比例为1:0.5〜3的药物层和推层的格列吡嗪控释组合物。 药物层含有格列吡嗪和40〜99重量％的亲水性聚乙烯吡咯烷酮均聚物和/或共聚物载体的药物层。 该推层包含按重量计的渗透聚合物的推进层的约10-80％，约为水性不溶性聚合物的推层重量的约10-80％，以及约5-50％ 一层渗透剂。 该组合物用于渗透泵片剂，用于控制每天一次给药的格列吡嗪类药物的释放。

公开(公告)号：US20080089937A1

公开(公告)日：2008-04-17

申请号：US11599150

申请日：2006-11-13

申请人： Yong Gan ,  Xinteng Zhou

发明人： Yong Gan ,  Xinteng Zhou

IPC分类号： A61K9/24

CPC分类号： A61K9/0004

摘要： A drug core composition is described for enhancing controlled delivery of pharmaceutical active agents with low solubility in water. The drug core composition contains at least a drug-layer and a push-layer. The drug-layer contains at least a pharmaceutical active agent with low solubility in water and a hydrophilic polymer carrier. The push-layer contains at least osmopolymers, water-insoluble polymers and osmagents. An osmotic pump system containing the drug core composition is described wherein a semi-permeable membrane is coated outside of the drug core composition. The drug core composition provides drug release at a controlled rate particularly adaptable for release of therapeutic dosages over a period of 24 hours when administered once a day.

摘要翻译： 描述了用于增强在水中溶解度低的药物活性剂的受控递送的药物核心组合物。 药物核心组合物至少含有药物层和推层。 药物层含有至少一种在水中具有低溶解度的药物活性剂和亲水性聚合物载体。 推层至少含有渗透聚合物，水不溶性聚合物和渗透剂。 描述了含有药物核心组合物的渗透泵系统，其中半透膜被涂覆在药物核心组合物的外部。 药物核心组合物以可控制的速率提供药物释放，特别适用于每天一次给药24小时内释放治疗剂量。

公开(公告)号：US20080075775A1

公开(公告)日：2008-03-27

申请号：US11580215

申请日：2006-10-11

申请人： Yong Gan ,  Xinteng Zhou

发明人： Yong Gan ,  Xinteng Zhou

IPC分类号： A61K9/24

CPC分类号： A61K9/0004 ,  A61K31/18

摘要： An osmotic pump device for delivery of tamsulosin or a pharmaceutically acceptable salt thereof to the gastrointestinal tract is provided. The device is a two-layer device comprising a drug containing layer containing as a carrier about 10 to 99 percent by weight of the first layer a polyvinylpyrrolidone polymer and/or copolymer, and a second layer comprising about 10 to 80 percent by weight of the second layer of water-insoluble volume-swellable polymers, about 80 to 10 percent by weight of the second layer of osmopolymers, and about 5 to 50 percent by weight of the second layer of osmagents.

摘要翻译： 提供了用于将坦索罗辛或其药学上可接受的盐递送至胃肠道的渗透泵装置。 该装置是一种双层装置，其包含药物含有层，其含有作为第一层的约10-99重量％的聚乙烯吡咯烷酮聚合物和/或共聚物的载体，第二层包含约10-80重量％ 第二层水不溶性体积溶胀性聚合物，约80至10重量％的第二层渗透聚合物，和约5至50重量％的第二层渗透剂。

公开(公告)号：US20080095840A1

公开(公告)日：2008-04-24

申请号：US11634816

申请日：2006-12-05

申请人： Yong Gan ,  Xinteng Zhou

发明人： Yong Gan ,  Xinteng Zhou

IPC分类号： A61K9/22 ,  A61K9/36 ,  A61K9/42

CPC分类号： A61K9/0004

摘要： A nifedipine controlled release composition is provided comprising a drug-layer and a push-layer at a ratio of 1:0.5˜3 by weight. The drug-layer contains nifedipine and 40˜99 percent by weight of the drug-layer of hydrophilic polyvinylpyrrolidone homopolymer and/or copolymer carrier. The push-layer comprises about 10 to 80 percent by weight of the push-layer of osmopolymers, about 10 to 80 percent by weight of the push-layer of water-insoluble polymers, and about 5 to 50 percent by weight of the push-layer of osmagents. The composition is used in osmotic pump tablets for controlled release of nifedipine useful for administration once a day.

摘要翻译： 提供了硝苯地平控释组合物，其包含按重量比为1：0.5〜3的药物层和推层。 药物层含有硝苯地平和40〜99重量％的亲水聚乙烯吡咯烷酮均聚物和/或共聚物载体的药物层。 该推层包含按重量计的渗透聚合物的推进层的约10-80％，约为水性不溶性聚合物的推层重量的约10-80％，以及约5-50％ 一层渗透剂。 该组合物用于渗透泵片剂，用于每日一次可用于一次给药的硝苯地平的控制释放。

公开(公告)号：US08776862B2

公开(公告)日：2014-07-15

申请号：US13462628

申请日：2012-05-02

申请人： Yong Gan ,  Chunzheng Yang ,  Hui Zhang ,  Jianhua Liu ,  Mei Wang ,  Gang Wei ,  Yeming Wu ,  Guozhong Peng ,  Minglin Wang ,  Hongbing Liang ,  Hongbiao Tao ,  Li Wang ,  Changsuo Xi ,  Baosheng Wang ,  Xiuqin Ji ,  Luchun Yuan ,  Yang Zhang

发明人： Yong Gan ,  Chunzheng Yang ,  Hui Zhang ,  Jianhua Liu ,  Mei Wang ,  Gang Wei ,  Yeming Wu ,  Guozhong Peng ,  Minglin Wang ,  Hongbing Liang ,  Hongbiao Tao ,  Li Wang ,  Changsuo Xi ,  Baosheng Wang ,  Xiuqin Ji ,  Luchun Yuan ,  Yang Zhang

IPC分类号： B22D11/043

CPC分类号： B22D11/043 ,  B22D11/0408

摘要： A chamfered narrow side copper plate for a mold with a funnel-shaped curved surface has a working face contacting molten steel that includes a middle area and two chamfered areas, which are arranged at two sides. The working face has a funnel-shaped curved surface, which is larger at a top and smaller at a bottom. The chamfered narrow side copper plate for mold with funnel-shaped curved surface can ensure the uniformity of the cooling effect of the chamfered surface and enhance the service life of the narrow side copper plate.

摘要翻译： 具有漏斗状曲面的模具的倒角窄边铜板具有接触钢水的工作面，该工作面包括布置在两侧的中间区域和两个倒角区域。 工作面具有漏斗形的曲面，其顶部较大，底部较小。 具有漏斗形曲面的倒角窄边铜板可确保倒角表面的冷却效果均匀，提高窄边铜板的使用寿命。