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公开(公告)号：US08956654B2
公开(公告)日：2015-02-17
申请号：US13254115
申请日：2009-06-02
申请人： Yong Gan , Chunliu Zhu , Sophie Zhai , Robert I. Schmitt , Ka Chun A. Chan
发明人： Yong Gan , Chunliu Zhu , Sophie Zhai , Robert I. Schmitt , Ka Chun A. Chan
CPC分类号： A61K9/0004 , A61K31/00
摘要： An osmotic dosage form which comprising: (a) a core comprising a biologically active ingredient; (b) a semi-permeable membrane covering said core; and (c) at least one passageway through the semi-permeable membrane, wherein the semi-permeable membrane comprises ethyl cellulose, an acrylic or methacrylic polymer and a water-soluble plasticizer with the proviso that the semi-permeable membrane comprises no or not more than 15 weight percent of a water-soluble material excluding any water-soluble plasticizer, based on the total dry weight of the semi-permeable membrane.
摘要翻译： 一种渗透剂型，其包含：（a）包含生物活性成分的核心; （b）覆盖所述芯的半透膜; 和（c）通过半透膜的至少一个通道，其中半透膜包括乙基纤维素，丙烯酸或甲基丙烯酸聚合物和水溶性增塑剂，条件是半透膜不包括或不多 不超过15重量％的水溶性材料，不包括任何水溶性增塑剂，基于半透膜的总干重。
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公开(公告)号：US20120045485A1
公开(公告)日：2012-02-23
申请号：US13254115
申请日：2009-06-02
申请人： Yong Gan , Chunliu Zhu , Sophie Zhai , Robert I. Schmitt , Ka Chun A. Chan
发明人： Yong Gan , Chunliu Zhu , Sophie Zhai , Robert I. Schmitt , Ka Chun A. Chan
CPC分类号： A61K9/0004 , A61K31/00
摘要： An osmotic dosage form which comprising: (a) a core comprising a biologically active ingredient; (b) a semi-permeable membrane covering said core; and (c) at least one passageway through the semi-permeable membrane, wherein the semi-permeable membrane comprises ethyl cellulose, an acrylic or methacrylic polymer and a water-soluble plasticizer with the proviso that the semi-permeable membrane comprises no or not more than 15 weight percent of a water-soluble material excluding any water-soluble plasticizer, based on the total dry weight of the semi-permeable membrane.
摘要翻译： 一种渗透剂型，其包含：（a）包含生物活性成分的核心; （b）覆盖所述芯的半透膜; 和（c）通过半透膜的至少一个通道，其中半透膜包括乙基纤维素，丙烯酸或甲基丙烯酸聚合物和水溶性增塑剂，条件是半透膜不包括或不多 不超过15重量％的水溶性材料，不包括任何水溶性增塑剂，基于半透膜的总干重。
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3.发明申请公开(公告)号：US20080095840A1
公开(公告)日：2008-04-24
申请号：US11634816
申请日：2006-12-05
申请人： Yong Gan , Xinteng Zhou
发明人： Yong Gan , Xinteng Zhou
CPC分类号： A61K9/0004
摘要： A nifedipine controlled release composition is provided comprising a drug-layer and a push-layer at a ratio of 1:0.5˜3 by weight. The drug-layer contains nifedipine and 40˜99 percent by weight of the drug-layer of hydrophilic polyvinylpyrrolidone homopolymer and/or copolymer carrier. The push-layer comprises about 10 to 80 percent by weight of the push-layer of osmopolymers, about 10 to 80 percent by weight of the push-layer of water-insoluble polymers, and about 5 to 50 percent by weight of the push-layer of osmagents. The composition is used in osmotic pump tablets for controlled release of nifedipine useful for administration once a day.
摘要翻译： 提供了硝苯地平控释组合物，其包含按重量比为1：0.5〜3的药物层和推层。 药物层含有硝苯地平和40〜99重量％的亲水聚乙烯吡咯烷酮均聚物和/或共聚物载体的药物层。 该推层包含按重量计的渗透聚合物的推进层的约10-80％，约为水性不溶性聚合物的推层重量的约10-80％，以及约5-50％ 一层渗透剂。 该组合物用于渗透泵片剂，用于每日一次可用于一次给药的硝苯地平的控制释放。
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公开(公告)号：US09901930B2
公开(公告)日：2018-02-27
申请号：US14772073
申请日：2013-03-08
申请人： Yong-Gan Ha
发明人： Yong-Gan Ha
摘要： The present disclosure relates to a cone-shaped crusher. The cone-shaped crusher includes a main shaft, a mantle core assembly which is coupled to and movable up and down the main shaft, and a crushing gap control support positioned below the mantle core assembly and fixed to the main shaft. In addition, the crushing gap control support has an annular cylindrical unit extending upward therefrom and receiving a piston unit which extends downward from the mantle core assembly so that the piston unit is movable up and down in the cylindrical unit. The whole mantle core assembly formed with the piston unit moves up and down by a pressure of hydraulic oil flowing in and out of an internal space of the cylindrical unit.
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公开(公告)号：US09050600B2
公开(公告)日：2015-06-09
申请号：US14009109
申请日：2012-04-16
申请人： Yong-Gan Ha
发明人： Yong-Gan Ha
摘要： The invention relates to a cone-shaped crusher including a frame having a cavity, a main shaft disposed eccentrically in the frame, and an eccentric drive making the main shaft perform a gyratory movement. The eccentric drive includes an upper eccentric shaft, a lower eccentric shaft, and an eccentric bearing. The upper eccentric shaft has an opening provided at its central portion to allow the lower end portion of the main shaft to pass through the opening, and an upper coupling part provided at its lower portion and fastened to the lower eccentric shaft. The lower eccentric shaft has a lower coupling part fastened to the upper eccentric shaft. The eccentric bearing accommodates the lower end portion of the main shaft and is disposed in a space defined by the upper eccentric shaft and the lower eccentric shaft.
摘要翻译： 本发明涉及一种锥形破碎机，其包括具有空腔的框架，偏心地设置在框架中的主轴和使主轴执行旋转运动的偏心驱动。 偏心驱动器包括上偏心轴，下偏心轴和偏心轴承。 上偏心轴在其中心部分设有一开口，以允许主轴的下端部分穿过开口，上连接部分设置在其下部并固定在下偏心轴上。 下偏心轴具有紧固到上偏心轴的下联接部。 偏心轴承容纳主轴的下端部，配置在由上偏心轴和下偏心轴构成的空间内。
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6.发明申请CHAMFERED NARROW SIDE COPPER PLATE FOR MOULD WITH FUNNEL-SHAPED CURVED SURFACE 有权带有FUNNEL形状曲面的模具的窄边窄边铜板公开(公告)号：US20120279676A1
公开(公告)日：2012-11-08
申请号：US13462628
申请日：2012-05-02
申请人： Yong GAN , Chunzheng Yang , Hui Zhang , Jianhua Liu , Mei Wang , Gang Wei , Yeming Wu , Guozhong Peng , Minglin Wang , Hongbing Liang , Hongbiao Tao , Li Wang , Changsuo Xi , Baosheng Wang , Xiuqin Ji , Luchun Yuan , Yang Zhang
发明人： Yong GAN , Chunzheng Yang , Hui Zhang , Jianhua Liu , Mei Wang , Gang Wei , Yeming Wu , Guozhong Peng , Minglin Wang , Hongbing Liang , Hongbiao Tao , Li Wang , Changsuo Xi , Baosheng Wang , Xiuqin Ji , Luchun Yuan , Yang Zhang
IPC分类号： B22D11/043
CPC分类号： B22D11/043 , B22D11/0408
摘要： This invention involves in metal solidification and continuous casting field, especially a chamfered narrow side copper plate for mould with funnel-shaped curved surface. The working face of the narrow side copper plate (1) contacting molten steel comprise a middle area (2) and two chamfered areas (3, 4) which are arranged at two sides, and said working face has a funnel-shaped curved surface which is big at top and small at bottom. In present invention, the chamfered narrow side copper plate for mould with funnel-shaped curved surface can ensure the uniformity of the cooling effect of the chamfered surface and enhance the service life of the narrow side copper plate.
摘要翻译： 本发明涉及金属凝固和连续铸造领域，特别是用于具有漏斗形曲面的模具的倒角窄边铜板。 与钢水接触的窄边铜板（1）的工作面包括中间区域（2）和两侧设置的两个倒角区域（3,4），所述工作面具有漏斗形的曲面， 在顶部是大的，底部是小的。 在本发明中，具有漏斗状弯曲面的倒角窄边铜板可以确保倒角面的冷却效果的均匀性，提高窄边铜板的使用寿命。
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公开(公告)号：US20080089937A1
公开(公告)日：2008-04-17
申请号：US11599150
申请日：2006-11-13
申请人： Yong Gan , Xinteng Zhou
发明人： Yong Gan , Xinteng Zhou
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： A drug core composition is described for enhancing controlled delivery of pharmaceutical active agents with low solubility in water. The drug core composition contains at least a drug-layer and a push-layer. The drug-layer contains at least a pharmaceutical active agent with low solubility in water and a hydrophilic polymer carrier. The push-layer contains at least osmopolymers, water-insoluble polymers and osmagents. An osmotic pump system containing the drug core composition is described wherein a semi-permeable membrane is coated outside of the drug core composition. The drug core composition provides drug release at a controlled rate particularly adaptable for release of therapeutic dosages over a period of 24 hours when administered once a day.
摘要翻译： 描述了用于增强在水中溶解度低的药物活性剂的受控递送的药物核心组合物。 药物核心组合物至少含有药物层和推层。 药物层含有至少一种在水中具有低溶解度的药物活性剂和亲水性聚合物载体。 推层至少含有渗透聚合物，水不溶性聚合物和渗透剂。 描述了含有药物核心组合物的渗透泵系统，其中半透膜被涂覆在药物核心组合物的外部。 药物核心组合物以可控制的速率提供药物释放，特别适用于每天一次给药24小时内释放治疗剂量。
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公开(公告)号：US20080075775A1
公开(公告)日：2008-03-27
申请号：US11580215
申请日：2006-10-11
申请人： Yong Gan , Xinteng Zhou
发明人： Yong Gan , Xinteng Zhou
IPC分类号： A61K9/24
CPC分类号： A61K9/0004 , A61K31/18
摘要： An osmotic pump device for delivery of tamsulosin or a pharmaceutically acceptable salt thereof to the gastrointestinal tract is provided. The device is a two-layer device comprising a drug containing layer containing as a carrier about 10 to 99 percent by weight of the first layer a polyvinylpyrrolidone polymer and/or copolymer, and a second layer comprising about 10 to 80 percent by weight of the second layer of water-insoluble volume-swellable polymers, about 80 to 10 percent by weight of the second layer of osmopolymers, and about 5 to 50 percent by weight of the second layer of osmagents.
摘要翻译： 提供了用于将坦索罗辛或其药学上可接受的盐递送至胃肠道的渗透泵装置。 该装置是一种双层装置，其包含药物含有层，其含有作为第一层的约10-99重量％的聚乙烯吡咯烷酮聚合物和/或共聚物的载体，第二层包含约10-80重量％ 第二层水不溶性体积溶胀性聚合物，约80至10重量％的第二层渗透聚合物，和约5至50重量％的第二层渗透剂。
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公开(公告)号：US20190290629A1
公开(公告)日：2019-09-26
申请号：US16442049
申请日：2019-06-14
申请人： Yong Gan , Bingxue Meng , Yan Liu , Chunliu Zhu , Shiyan Guo
发明人： Yong Gan , Bingxue Meng , Yan Liu , Chunliu Zhu , Shiyan Guo
IPC分类号： A61K31/4439
摘要： Provided are a niraparib sustained and controlled release pharmaceutical composition and use thereof. The sustained and controlled release pharmaceutical composition contains dissolution-improved niraparib and a matrix polymer used for regulating release rate; the steady-state plasma concentration trough value Cmin,ss of the pharmaceutical composition is 0.5-4 μM; the steady-state plasma concentration peak value Cmax,ss is 0.8-6 μM.
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公开(公告)号：US20170106374A1
公开(公告)日：2017-04-20
申请号：US15318040
申请日：2015-06-10
申请人： Yong-Gan HA
发明人： Yong-Gan HA
CPC分类号： B02C13/1835 , B02C13/09 , B02C13/14 , B02C13/1807 , B02C13/1842 , B02C13/2804 , B02C2013/28681 , B02C2210/02
摘要： The present disclosure relates to a vertical shaft impact crusher comprising a rotor having a rotor protection layer which consists of particles of objects to be crushed. The rotor includes at least: a rotor upper plate comprising a rotor upper plate hole, which is an inlet for the object for crushing which is inserted into the rotor; a rotor lower plate disposed to be separated from the lower portion of the rotor upper plate; a rotor upper plate; a rotor side wall disposed between the rotor upper plate and the rotor lower plate and coupled to the rotor upper plate and the rotor lower plate, the rotor side wall being disposed at a position spaced from the rotation center of the rotor; and a circular hole which is formed on the rotor side wall and is an outlet for the object for crushing accelerated by the rotor to come out of the rotor.
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