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    Extraction and purification method of active constituents from stem of Lonicera japonica Thunb., its usage for anti-inflammatory and analgesic drug
    12.
    发明申请
    Extraction and purification method of active constituents from stem of Lonicera japonica Thunb., its usage for anti-inflammatory and analgesic drug 审中-公开
    枸杞茎中活性成分的提取及纯化方法，其用于抗炎镇痛药物

    公开(公告)号：US20070111955A1

    公开(公告)日：2007-05-17

    申请号：US11652360

    申请日：2007-01-11

    申请人： Wie-Jong Kwak ,  Yong-Baik Cho ,  Chang-Kyun Han ,  Hee Shin ,  Keun Ryu ,  Hunseung Yoo ,  Hae Rhee

    发明人： Wie-Jong Kwak ,  Yong-Baik Cho ,  Chang-Kyun Han ,  Hee Shin ,  Keun Ryu ,  Hunseung Yoo ,  Hae Rhee

    IPC分类号： A61K31/7048

    CPC分类号： A61K36/355

    摘要： Disclosed is a method for extracting and purifying active constituents from honeysuckle (Lonicera japonica Thunb.) and its use. More particularly, this invention relates to an extraction and purification method of active constituents including sweroside from for honeysuckle stem (stem of honeysuckle where leaves are removed) by removing tannins, hardly soluble flavonoids, saponins, and the like. Thus obtained active constituents have better anti-inflammatory and analgesic effect, are safer and more stable than the conventional active constituents obtained from honeysuckle flower or honeysuckle leaves, and include sweroside which is an effective active ingredient of anti-inflammatory and analgesic drug.

    摘要翻译： 公开了一种从金银花（金银花）提取和提纯活性成分的方法及其用途。 更具体地说，本发明涉及通过除去单宁，几乎不溶于黄酮，皂苷等的金银花茎（金银花茎除去叶子）的活性成分的提取和提纯方法。 由此得到的活性成分具有更好的抗炎和止痛作用，比从金银花或金银花叶中获得的常规活性成分更安全，更稳定，并且包括作为抗炎和止痛药有效活性成分的替罗非苷。

    Sophorae Radix extract for prevention and treatment of respiratory diseases
    13.
    发明授权
    Sophorae Radix extract for prevention and treatment of respiratory diseases 有权
    苦参提取物用于预防和治疗呼吸系统疾病

    公开(公告)号：US09180153B2

    公开(公告)日：2015-11-10

    申请号：US12778793

    申请日：2010-05-12

    申请人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

    发明人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

    IPC分类号： A61K36/489

    CPC分类号： A61K36/489 ,  A61K2236/33

    摘要： The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

    摘要翻译： 本发明涉及从用于预防和治疗呼吸系统疾病的苦参中分离的提取物。 更具体地说，本发明涉及包含苦参提取物具有抑制气道收缩，呼吸道感染，5-脂氧合酶活性，磷酸二酯酶4活性，气道高反应性和气道重构的优异效果的药物。 白三烯D4拮抗活性; 和镇咳作用，因此可用于预防和治疗诸如哮喘，急性或慢性支气管炎，过敏性鼻炎，急性上呼吸道感染和急性下呼吸道感染等呼吸系统疾病。

    SOPHORAE RADIX EXTRACT FOR PREVENTION AND TREATMENT OF RESPIRATORY DISEASES
    15.
    发明申请
    SOPHORAE RADIX EXTRACT FOR PREVENTION AND TREATMENT OF RESPIRATORY DISEASES 审中-公开
    SOPHORAE RADIX预防和治疗呼吸道疾病的提取物

    公开(公告)号：US20100221371A1

    公开(公告)日：2010-09-02

    申请号：US12778793

    申请日：2010-05-12

    申请人： Chang-Kyun HAN ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

    发明人： Chang-Kyun HAN ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

    IPC分类号： A61K36/00 ,  A61P11/00

    CPC分类号： A61K36/489 ,  A61K2236/33

    摘要： The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

    摘要翻译： 本发明涉及从用于预防和治疗呼吸系统疾病的苦参中分离的提取物。 更具体地说，本发明涉及包含苦参提取物具有抑制气道收缩，呼吸道感染，5-脂氧合酶活性，磷酸二酯酶4活性，气道高反应性和气道重构的优异效果的药物。 白三烯D4拮抗活性; 和镇咳作用，因此可用于预防和治疗诸如哮喘，急性或慢性支气管炎，过敏性鼻炎，急性上呼吸道感染和急性下呼吸道感染等呼吸系统疾病。

    Sophorae Subprostratae Radix Extract for Prevention and Treatment of Respiratory Diseases
    18.
    发明申请
    Sophorae Subprostratae Radix Extract for Prevention and Treatment of Respiratory Diseases 审中-公开
    芍药提取物用于预防和治疗呼吸系统疾病

    公开(公告)号：US20080107757A1

    公开(公告)日：2008-05-08

    申请号：US11666392

    申请日：2005-10-21

    申请人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

    发明人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

    IPC分类号： A61K36/489 ,  A61P11/00

    CPC分类号： A61K36/489 ,  A61K2236/33

    摘要： The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

    摘要翻译： 本发明涉及从用于预防和治疗呼吸系统疾病的苦参中分离的提取物。 更具体地说，本发明涉及包含苦参提取物具有抑制气道收缩，呼吸道感染，5-脂氧合酶活性，磷酸二酯酶4活性，气道高反应性和气道重构的优异效果的药物。 白三烯D 4拮抗活性; 和镇咳作用，因此可用于预防和治疗诸如哮喘，急性或慢性支气管炎，过敏性鼻炎，急性上呼吸道感染和急性下呼吸道感染等呼吸系统疾病。

    Extraction and purification method of active constituents from stem of lonicera japonica thunb., its usage for anti-inflammatory and analgesic drug
    19.
    发明申请
    Extraction and purification method of active constituents from stem of lonicera japonica thunb., its usage for anti-inflammatory and analgesic drug 失效
    枸杞茎中活性成分的提取和纯化方法，其用于抗炎镇痛药物

    公开(公告)号：US20060014240A1

    公开(公告)日：2006-01-19

    申请号：US10527139

    申请日：2003-09-08

    申请人： Wie-Jong Kwak ,  Yong-Baik Cho ,  Chang-Kyun Han ,  Hee Shin ,  Keun Ryu ,  Hunseung Yoo ,  Hai Rhee

    发明人： Wie-Jong Kwak ,  Yong-Baik Cho ,  Chang-Kyun Han ,  Hee Shin ,  Keun Ryu ,  Hunseung Yoo ,  Hai Rhee

    IPC分类号： C12P21/06 ,  A61K36/185

    CPC分类号： A61K36/355

    摘要： Disclosed is a method for extracting and purifying active constituents from honeysuckle (Lonicera japonica Thunb.) and its use. More particularly, this invention relates to an extraction and purification method of active constituents including sweroside from for honeysuckle stem (stem of honeysuckle where leaves are removed) by removing tannins, hardly soluble flavonoids, saponins, and the like. Thus obtained active constituents have better anti-inflammatory and analgesic effect, are safer and more stable than the conventional active constituents obtained from honeysuckle flower or honeysuckle leaves, and include sweroside which is an effective active ingredient of anti-inflammatory and analgesic drug.

    摘要翻译： 公开了一种从金银花（金银花）提取和提纯活性成分的方法及其用途。 更具体地说，本发明涉及通过除去单宁，几乎不溶于黄酮，皂苷等的金银花茎（金银花茎除去叶子）的活性成分的提取和提纯方法。 由此得到的活性成分具有更好的抗炎和止痛作用，比从金银花或金银花叶中获得的常规活性成分更安全，更稳定，并且包括作为抗炎和止痛药有效活性成分的替罗非苷。