公开(公告)号：US09180153B2

公开(公告)日：2015-11-10

申请号：US12778793

申请日：2010-05-12

申请人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

发明人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

IPC分类号： A61K36/489

CPC分类号： A61K36/489 ,  A61K2236/33

摘要： The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

摘要翻译： 本发明涉及从用于预防和治疗呼吸系统疾病的苦参中分离的提取物。 更具体地说，本发明涉及包含苦参提取物具有抑制气道收缩，呼吸道感染，5-脂氧合酶活性，磷酸二酯酶4活性，气道高反应性和气道重构的优异效果的药物。 白三烯D4拮抗活性; 和镇咳作用，因此可用于预防和治疗诸如哮喘，急性或慢性支气管炎，过敏性鼻炎，急性上呼吸道感染和急性下呼吸道感染等呼吸系统疾病。

公开(公告)号：US20100221371A1

公开(公告)日：2010-09-02

申请号：US12778793

申请日：2010-05-12

申请人： Chang-Kyun HAN ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

发明人： Chang-Kyun HAN ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

IPC分类号： A61K36/00 ,  A61P11/00

CPC分类号： A61K36/489 ,  A61K2236/33

摘要： The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

摘要翻译： 本发明涉及从用于预防和治疗呼吸系统疾病的苦参中分离的提取物。 更具体地说，本发明涉及包含苦参提取物具有抑制气道收缩，呼吸道感染，5-脂氧合酶活性，磷酸二酯酶4活性，气道高反应性和气道重构的优异效果的药物。 白三烯D4拮抗活性; 和镇咳作用，因此可用于预防和治疗诸如哮喘，急性或慢性支气管炎，过敏性鼻炎，急性上呼吸道感染和急性下呼吸道感染等呼吸系统疾病。

公开(公告)号：US20080107757A1

公开(公告)日：2008-05-08

申请号：US11666392

申请日：2005-10-21

申请人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

发明人： Chang-Kyun Han ,  Kiwon Joung ,  Hunseung Yoo ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hye Yeon Baek ,  Taek-Soo Kim ,  In Ho Jung ,  Wie-Jong Kwak

IPC分类号： A61K36/489 ,  A61P11/00

CPC分类号： A61K36/489 ,  A61K2236/33

摘要： The present invention relates to an extract isolated from Sophorae Radix useful for prevention and treatment of respiratory diseases. More specifically, the present invention relates to a pharmaceutical drug comprising the Sophorae Radix extract having excellent effects of inhibiting airway contraction, respiratory infections, 5-lipoxygenase activity, phosphodiesterase 4 activity, airway hyper-responsiveness and airway remodeling; antagonistic activity against leukotriene D4; and an antitussive effect, thus being useful for prevention and treatment of respiratory diseases such as asthma, acute or chronic bronchitis, allergic rhinitis, acute upper respiratory infections and acute lower respiratory infections, and the like.

摘要翻译： 本发明涉及从用于预防和治疗呼吸系统疾病的苦参中分离的提取物。 更具体地说，本发明涉及包含苦参提取物具有抑制气道收缩，呼吸道感染，5-脂氧合酶活性，磷酸二酯酶4活性，气道高反应性和气道重构的优异效果的药物。 白三烯D 4拮抗活性; 和镇咳作用，因此可用于预防和治疗诸如哮喘，急性或慢性支气管炎，过敏性鼻炎，急性上呼吸道感染和急性下呼吸道感染等呼吸系统疾病。

公开(公告)号：US08652537B2

公开(公告)日：2014-02-18

申请号：US13400784

申请日：2012-02-21

申请人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

发明人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

IPC分类号： A61K36/00

CPC分类号： A61K36/536 ,  A61K36/428 ,  A61K36/716 ,  A61K2300/00

摘要： The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

摘要翻译： 本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），夏枯草（Prunellae Spica）的植物提取物和迷迭香酸的最佳含量，以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。

公开(公告)号：US09833487B2

公开(公告)日：2017-12-05

申请号：US12865995

申请日：2009-02-19

申请人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

发明人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

IPC分类号： A61K36/355 ,  A61K36/8964 ,  A23L33/105

CPC分类号： A61K36/355 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/8964 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2200/306 ,  A23V2200/316

摘要： In some embodiments, a composition for the treatment and inhibition or prevention of arthritic diseases includes an extract of mixed herbs, the mixed herbs including an active ingredient with Lonicera japonica THUNB and Anemarrhena asphodeloides BUNGE.

公开(公告)号：US20140030368A1

公开(公告)日：2014-01-30

申请号：US13982002

申请日：2012-01-30

申请人： Yong Baik Cho ,  Moon Kyu Kang ,  In Ho Jung ,  Jong Hyun Hur ,  Soon Han Kim ,  Kyoung Chul Jung ,  Je Young Lee ,  Seul Ki Kim ,  Jee Young Lee ,  Byung Chul Yu ,  Min-Kyong Hyon

发明人： Yong Baik Cho ,  Moon Kyu Kang ,  In Ho Jung ,  Jong Hyun Hur ,  Soon Han Kim ,  Kyoung Chul Jung ,  Je Young Lee ,  Seul Ki Kim ,  Jee Young Lee ,  Byung Chul Yu ,  Min-Kyong Hyon

IPC分类号： A61K36/704 ,  A61K36/234

CPC分类号： A61K36/704 ,  A61K36/234 ,  A61K2300/00

摘要： The present invention relates to a composition for preventing or treating a respiratory disease containing an active ingredient in the form of a mixed herbal extract of Cnidii Rhizoma and Polygoni cuspidati Radix, and relates to a production method therefor. The mixed herbal extract of Cnidii Rhizoma and Polygoni cuspidati Radix has an outstanding 5-lipoxygenase suppressing activity, airway constriction suppressing activity, airway inflammation suppressing action, ear-swelling anti-inflammatory effect and antitussive and phlegm-loosening action, and has been confirmed to be useful in preventing or treating respiratory diseases including asthma, chronic obstructive pulmonary disease, acute and chronic bronchitis, allergic rhinitis, cough, expectoration, acute lower respiratory infections (bronchitis and bronchiolitis), and acute upper respiratory infections such an pharyngitis, tonsillitis and laryngitis.

摘要翻译： 本发明涉及用于预防或治疗含有Cnidii Rhizoma和Polygoni cuspidati Radix的混合草药提取物形式的活性成分的呼吸系统疾病的组合物，涉及其生产方法。 Cnidii Rhizoma和Polygoni cuspidati Radix的混合草药提取物具有突出的5-脂氧合酶抑制活性，气道收缩抑制活性，气道炎症抑制作用，耳肿胀抗炎作用和镇咳和痰松动作用，并已被证实为 可用于预防或治疗呼吸系统疾病，包括哮喘，慢性阻塞性肺病，急性和慢性支气管炎，过敏性鼻炎，咳嗽，咳痰，急性下呼吸道感染（支气管炎和细支气管炎）以及急性上呼吸道感染如咽炎，扁桃体炎和喉炎 。

公开(公告)号：US20110003018A1

公开(公告)日：2011-01-06

申请号：US12865995

申请日：2009-02-19

申请人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

发明人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

IPC分类号： A61K36/355 ,  A61K36/896 ,  A61P19/02 ,  A61P29/00

CPC分类号： A61K36/355 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/8964 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2200/306 ,  A23V2200/316

摘要： In some embodiments, a composition for the treatment and inhibition or prevention of arthritic diseases includes an extract of mixed herbs, the mixed herbs including an active ingredient with Lonicera japonica THUNB and Anemarrhena asphodeloides BUNGE.

摘要翻译： 在一些实施方案中，用于治疗和抑制或预防关节炎疾病的组合物包括混合草药的提取物，所述混合草药包括与忍冬（Ronicera japonica）THUNB和Anemarrhena asphodeloides BUNGE的活性成分。