公开(公告)号：US20090275574A1

公开(公告)日：2009-11-05

申请号：US12432818

申请日：2009-04-30

Applicant: Yun-Xing Cheng ,  Vijayaratnam Santhakumar ,  Miroslaw Jerzy Tomaszewski

Inventor： Yun-Xing Cheng ,  Vijayaratnam Santhakumar ,  Miroslaw Jerzy Tomaszewski

IPC: A61K31/517 ,  C07D401/04 ,  A61K31/538 ,  A61P25/28 ,  A61P25/18

CPC classification number: C07D401/04 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, m, n, q, s, t, X, and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract translation: 式I化合物或其药学上可接受的盐：其中R1，R2，R3，R4，m，n，q，s，t，X和Y如说明书中所定义，以及包括化合物 准备好了 它们可用于治疗，特别是治疗疼痛。

公开(公告)号：US20090076078A1

公开(公告)日：2009-03-19

申请号：US12205968

申请日：2008-09-08

Applicant: Yun-Xing Cheng ,  Xuehong Luo ,  Vijayaratnam Santhakumar ,  Miroslaw Jerzy Tomaszewski

Inventor： Yun-Xing Cheng ,  Xuehong Luo ,  Vijayaratnam Santhakumar ,  Miroslaw Jerzy Tomaszewski

IPC: A61K31/4545 ,  C07D401/14 ,  A61K31/454 ,  A61P25/00

CPC classification number: C07D401/04 ,  C07D211/74 ,  C07D401/14

Abstract: Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R2, R3, X, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract translation: 式I的化合物或其药学上可接受的盐：其中R2，R3，X，m和n如说明书中所定义，以及包括所述化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。

公开(公告)号：US20100113502A1

公开(公告)日：2010-05-06

申请号：US11909089

申请日：2006-03-17

Applicant: Yun-Xing Cheng ,  Miroslaw Tomaszewski

Inventor： Yun-Xing Cheng ,  Miroslaw Tomaszewski

IPC: A61K31/437 ,  C07D471/04 ,  A61P25/22

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Compounds of formulae I, or pharmaceutically acceptable salts thereof: wherein R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract translation: 式I化合物或其药学上可接受的盐：其中R1，R2和R3如说明书中所定义，以及包括该化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。

公开(公告)号：US20070259888A1

公开(公告)日：2007-11-08

申请号：US11741888

申请日：2007-04-30

Applicant: Yun-Xing Cheng ,  Xuehong Luo ,  Miroslaw Tomaszewski

Inventor： Yun-Xing Cheng ,  Xuehong Luo ,  Miroslaw Tomaszewski

IPC: A61K31/519 ,  A61K31/497 ,  A61K31/4545 ,  A61K31/454 ,  C07D401/02 ,  C07D403/02

CPC classification number: C07D405/12 ,  C07C235/50 ,  C07C235/54 ,  C07C2601/14 ,  C07D207/327 ,  C07D209/08 ,  C07D209/42 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/38 ,  C07D211/44 ,  C07D213/56 ,  C07D213/82 ,  C07D231/12 ,  C07D231/56 ,  C07D233/90 ,  C07D235/26 ,  C07D241/26 ,  C07D249/18 ,  C07D261/18 ,  C07D263/32 ,  C07D263/34 ,  C07D265/36 ,  C07D277/62 ,  C07D295/135 ,  C07D307/68 ,  C07D307/80 ,  C07D307/85 ,  C07D309/06 ,  C07D317/68 ,  C07D319/16 ,  C07D321/10 ,  C07D333/24 ,  C07D333/38 ,  C07D333/68 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/10

Abstract: Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract translation: 式I化合物或其药学上可接受的盐：其中X，R 1，R 2和R 3如在本说明书中所定义，如 以及制备包括这些化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。