公开(公告)号：US11337902B2

公开(公告)日：2022-05-24

申请号：US16871422

申请日：2020-05-11

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Yizhong Wang ,  Tiffany T. Ton ,  Melinda B. Gustafson ,  Jennifer Post ,  Paul R. Klaiber ,  Carola A. Carrera Vidal ,  Joel D. Oxman

IPC: A61K8/21 ,  A61K45/06 ,  A61K33/16 ,  A61K8/73 ,  A61K8/27 ,  A61C19/06 ,  A61K8/19 ,  A61K8/24 ,  A61K8/26 ,  A61K8/81 ,  A61Q11/00

Abstract: An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.

公开(公告)号：US20210353387A1

公开(公告)日：2021-11-18

申请号：US17284540

申请日：2019-10-11

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Bhaskar V. Velamakanni ,  Paul R. Klaiber ,  Richard P. Rusin ,  Daniel J. Skamser ,  Negus B. Adefris

IPC: A61C7/08 ,  A61C19/06 ,  A61K6/69

Abstract: A dental appliance is described, the dental appliance including a polymeric substrate with a plurality of cavities for receiving one or more teeth, an arrangement of engineered microstructures on the substrate wherein the engineered microstructures include a therapeutic agent. The microstructures may be three-dimensionally engineered on a polymeric film disposed on a major surface of the polymeric substrate, wherein the microstructures extend outwards from the surface. The microstructures also comprise a compound releasable from the three-dimensionally engineered microstructures over a predetermined patient wear time.

公开(公告)号：US11666523B2

公开(公告)日：2023-06-06

申请号：US16644415

申请日：2018-08-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Yizhong Wang ,  Tiffany T. Ton ,  Carola A. Carrera Vidal ,  Joel D. Oxman ,  Jennifer J. Post ,  Paul R. Klaiber

IPC: A61K8/81 ,  A61K8/21 ,  A61K8/73 ,  A61Q11/00

CPC classification number: A61K8/8147 ,  A61K8/21 ,  A61K8/73 ,  A61Q11/00 ,  A61K2800/5426 ,  A61K2800/56

Abstract: An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patients tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.5 wt-% to 4.8 wt-% of a water-soluble cationic N-containing polymer; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.

公开(公告)号：US20220211603A1

公开(公告)日：2022-07-07

申请号：US17594914

申请日：2020-05-18

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Richard P. Rusin ,  Jie Yang ,  Petra L. Kohler Riedi ,  Jodi L. Connell ,  Ingo Haeberlein ,  Hannah C. Cohen ,  Katie F. Wlaschin ,  Paul R. Klaiber ,  Yizhong Wang ,  Joel D. Oxman ,  Tiffany T. Ton ,  Roxanne A. Boehmer

IPC: A61K8/60 ,  A61K8/04 ,  A61Q11/00

Abstract: A composition comprising from 1 wt-% to 3 wt-% total of glucosamine a derivative of glucosamine, or a combination thereof based on the total weight of the composition, and from 0.3 wt-% to 3 wt-% total of one or more surfactants, based on the total weight of the composition, of Formula (I): HOCH2—(OHOH)n—CH2NR1R2 (I) wherein R1 and R2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R3 and SO2R4 with R3 and R4 being independently selected from the group consisting of an alkyl group, an aryl group and an aralkyl group, wherein n is an integer from 2 to 5.

公开(公告)号：US20220192953A1

公开(公告)日：2022-06-23

申请号：US17594878

申请日：2020-05-20

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Richard P. Rusin ,  Jie Yang ,  Petra L. Kohler Riedi ,  Jodi L. Connell ,  Ingo Haeberlein ,  Katie F. Wlaschin ,  Hannah C. Cohen ,  Tiffany T. Ton ,  Paul R. Klaiber ,  Yizhong Wang ,  Joel D. Oxman

IPC: A61K8/44 ,  A61K8/60 ,  A61Q11/00

Abstract: A composition comprising: from 0.2 wt-% to 3 wt-% total of arginine, glycine, or a combination thereof based on the total weight of the composition; and from 0.3 wt-% to 3 wt-% total of one or more surfactants, based on the total weight of the composition, of Formula I: HOCH2—(CHOH)n—CH2NR1R2 (I) wherein R1 and R2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R3, and SO2R4; with R3 and R4 being independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; wherein n is an integer from about 2 to about 5.

公开(公告)号：US10682300B2

公开(公告)日：2020-06-16

申请号：US16148415

申请日：2018-10-01

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Yizhong Wang ,  Tiffany T. Ton ,  Melinda B. Gustafson ,  Jennifer Post ,  Paul R. Klaiber ,  Carola A. Carrera Vidal ,  Joel D. Oxman

IPC: A61K8/21 ,  A61K45/06 ,  A61K33/16 ,  A61K8/73 ,  A61K8/27 ,  A61C19/06 ,  A61K8/19 ,  A61K8/24 ,  A61K8/26 ,  A61K8/81 ,  A61Q11/00

Abstract: An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.

公开(公告)号：US20190183621A1

公开(公告)日：2019-06-20

申请号：US16202340

申请日：2018-11-28

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Bruce R. Broyles ,  Paul R. Klaiber ,  Jennifer Post

IPC: A61C19/06 ,  A61Q11/00 ,  A61K8/21 ,  A61K8/81

CPC classification number: A61C19/063 ,  A61K8/21 ,  A61K8/8147 ,  A61K2800/87 ,  A61Q11/00

Abstract: A method of applying a dental treatment composition to a patient's teeth, including selecting a dental treatment composition, applying the dental treatment composition to a surface of at least one tooth of the patient; and applying pressurized gas on the dental treatment composition to spread the dental treatment composition smoothly across the surface of the tooth.

公开(公告)号：US10064802B2

公开(公告)日：2018-09-04

申请号：US14917431

申请日：2014-09-10

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Yizhong Wang ,  Joel D. Oxman ,  Paul R. Klaiber ,  Jie J. Liu ,  Joanne A. Fitch ,  Tiffany T. Ton ,  Reinhold Hecht

IPC: A61K8/81 ,  A61Q11/00

Abstract: An oral composition and a method of delivering an oral composition to a dental structure are described. The oral composition can include a solvent; an acidic copolymer having acidic acrylate monomeric units, acidic methacrylate monomeric units, or a combination thereof; a neutral copolymer having neutral acrylate monomeric units, neutral methacrylate monomeric units, or a combination thereof; and optionally an active agent. The acidic and neutral copolymers can be dissolved in the oral composition and the oral composition can form a film on a surface when contacted with an aqueous solution.