公开(公告)号：US09682222B2

公开(公告)日：2017-06-20

申请号：US14892238

申请日：2014-05-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Scott A. Burton ,  Chin-Yee Ng ,  Richard R. Mathias

IPC: A61M37/00 ,  A61M5/32

CPC classification number: A61M37/0015 ,  A61B5/150022 ,  A61B5/150984 ,  A61M5/322 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A microneedle injection apparatus (100) comprising an inverted actuator. The apparatus can include a housing (102) having a base and a cavity, and a microneedle array holder (106) configured to hold a microneedle array (107) within the cavity of the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include an actuator (104) movable with respect to the housing and the microneedle array holder between a first position and a second position to cause the microneedle array holder to move from the retracted position to the extended position. At least a portion of the actuator can be located on a skin-facing side of the apparatus (e.g., adjacent the base of the housing) and can be configured to be moved from the first position to the second position in response to the apparatus being pressed toward the skin surface.

公开(公告)号：US20160121091A1

公开(公告)日：2016-05-05

申请号：US14892265

申请日：2014-05-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Scott A. Burton ,  Chin-Yee Ng ,  Richard R. Mathias ,  Thomas D. R. Ford

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M5/24 ,  A61M5/32 ,  A61M5/3202 ,  A61M5/322 ,  A61M2005/2414 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0061

Abstract: A microneedle injection apparatus comprising a dual cover. The apparatus can include a housing having a base and a cavity; a microneedle array comprising a first side comprising a plurality of microneedles; and a microneedle array holder configured to hold a microneedle array and located in the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include a cover (113) configured to be positioned to cover the opening (115) in the base (112) of the housing. The cover can include (i) a first portion (140) configured to cover at least a portion of the base of the housing adjacent the opening, and (ii) a second portion (142) configured to be received in the cavity of the housing and further configured to cover the plurality of microneedles on the microneedle array when the microneedle array holder is in the retracted position.

Abstract translation: 一种包括双层盖的微针注射装置。 该装置可以包括具有底座和空腔的壳体; 微针阵列，包括包括多个微针的第一侧; 以及配置成保持微针阵列并位于壳体中的微针阵列保持器。 微针阵列保持器可以在缩回位置和延伸位置之间移动。 该装置还可以包括构造成定位成覆盖壳体的基部（112）中的开口（115）的盖（113）。 所述盖可以包括（i）第一部分（140），其构造成覆盖邻近所述开口的所述壳体的所述基部的至少一部分，以及（ii）构造成容纳在所述壳体的空腔中的第二部分 并且还被配置为当微针阵列保持器处于缩回位置时覆盖微针阵列上的多个微针。

公开(公告)号：US20160082242A1

公开(公告)日：2016-03-24

申请号：US14892249

申请日：2014-05-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Scott A. Burton ,  Chin-Yee Ng ,  Michael J. Frits ,  Richard R. Mathias

IPC: A61M37/00 ,  A61M5/32

CPC classification number: A61M37/0015 ,  A61M5/14248 ,  A61M5/322 ,  A61M5/3297 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A microneedle injection and infusion apparatus, and a method of using same. The apparatus (100) can include a housing (102), a microneedle array holder (106) for holding a microneedle array (107), and a shuttle (125) that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator (104) movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.

Abstract translation: 微针注射输液装置及其使用方法。 装置（100）可以包括壳体（102），用于保持微针阵列（107）的微针阵列保持器（106）和保持盒（例如，包含活性剂）的梭子（125）。 微针阵列保持器可以在缩回位置和延伸位置之间移动。 梭子可以在盒不与流体路径流体连通的第一位置和盒与流体路径流体连通的第二位置之间移动。 该装置还可包括可在第一位置和第二位置之间移动的致动器（104）。 该方法可以包括将致动器移动到其第二位置以允许梭子朝向其第二位置移动，其中梭子朝向其第二位置的运动允许微针阵列保持器移动到其延伸位置。

公开(公告)号：US20160082241A1

公开(公告)日：2016-03-24

申请号：US14892238

申请日：2014-05-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Scott A. Burton ,  Chin-Yee Ng ,  Richard R. Mathias

IPC: A61M37/00 ,  A61M5/32

CPC classification number: A61M37/0015 ,  A61B5/150022 ,  A61B5/150984 ,  A61M5/322 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A microneedle injection apparatus (100) comprising an inverted actuator. The apparatus can include a housing (102) having a base and a cavity, and a microneedle array holder (106) configured to hold a microneedle array (107) within the cavity of the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include an actuator (104) movable with respect to the housing and the microneedle array holder between a first position and a second position to cause the microneedle array holder to move from the retracted position to the extended position. At least a portion of the actuator can be located on a skin-facing side of the apparatus (e.g., adjacent the base of the housing) and can be configured to be moved from the first position to the second position in response to the apparatus being pressed toward the skin surface.

Abstract translation: 一种包括倒置致动器的微针注射装置（100）。 该装置可以包括具有底座和空腔的壳体（102）和配置成将微针阵列（107）保持在壳体的空腔内的微针阵列保持器（106）。 微针阵列保持器可以在缩回位置和延伸位置之间移动。 该装置还可以包括可在第一位置和第二位置之间相对于壳体和微针阵列保持器移动的致动器（104），以使微针阵列保持器从缩回位置移动到延伸位置。 致动器的至少一部分可以位于设备的面向皮肤的一侧（例如，邻近壳体的基部），并且可以被配置为响应于装置而从第一位置移动到第二位置 压向皮肤表面。

公开(公告)号：US20150352295A1

公开(公告)日：2015-12-10

申请号：US14759757

申请日：2014-01-07

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Scott A. Burton ,  Craig S. Moeckly ,  Ryan P. Simmers

IPC: A61M5/50 ,  A61M37/00

CPC classification number: A61M5/5086 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2205/106

Abstract: An applicator and method for applying a microneedle device to skin. The applicator can include a housing and a reciprocating support structure slidably engaged with the housing. The reciprocating support structure can have a plurality of alignment feet. The applicator can have a lockout mechanism that prevents actuation if the alignment feet are not evenly aligned. The applicator can include a device life indicator that is capable of counting the number of use cycles that the applicator has undergone and providing feedback to the user. The applicator can include a dose timer capable of determining the time that has elapsed after actuation of the device and providing feedback to the user.

Abstract translation: 用于将微针装置施加到皮肤上的涂抹器和方法。 施加器可以包括壳体和与壳体可滑动地接合的往复运动支撑结构。 往复式支撑结构可以具有多个对准脚。 如果对准脚不均匀对准，施加器可以具有防止致动的锁定机构。 施用器可以包括能够计数施加器已经经历的使用周期数并向用户提供反馈的装置寿命指示器。 涂抹器可以包括剂量定时器，其能够确定在致动装置之后已经经过的时间并向用户提供反馈。